scholarly journals Interferon-inducer antivirals: Potential candidates to combat COVID-19

2021 ◽  
Vol 91 ◽  
pp. 107245
Author(s):  
Ashkan Bagheri ◽  
Seyed Mohammad Iman Moezzi ◽  
Pouria Mosaddeghi ◽  
Sadra Nadimi Parashkouhi ◽  
Seyed Mostafa Fazel Hoseini ◽  
...  
Keyword(s):  
Interferon Inducer

Uranyl Acetate and Rotary Shadowing to Increase the Contrast of Small Aggregated Virus Particles

1969 ◽  
Vol 27 ◽  
pp. 424-425
Author(s):  
Lee F. Ellis ◽  
Richard M. Van Frank ◽  
Walter J. Kleinschmidt
Keyword(s):  
Electron Microscopy ◽  
Tissue Culture ◽  
Density Gradient ◽  
Density Gradient Centrifugation ◽  
Gradient Centrifugation ◽  
Uranyl Acetate ◽  
Interferon Inducer ◽  
Virus Particles ◽  
Staining Methods ◽  
Rotary Shadowing

The extract from Penicillum stoliniferum, known as statolon, has been purified by density gradient centrifugation. These centrifuge fractions contained virus particles that are an interferon inducer in mice or in tissue culture. Highly purified preparations of these particles are difficult to enumerate by electron microscopy because of aggregation. Therefore a study of staining methods was undertaken.

scholarly journals Antiviral Activity of BL-3849A, a Low-Molecular-Weight Oral Interferon Inducer

1976 ◽  
Vol 10 (4) ◽  
pp. 691-696 ◽  
Author(s):  
E. R. Kern ◽  
J. R. Hamilton ◽  
J. C. Overall ◽  
L. A. Glasgow
Keyword(s):  
Molecular Weight ◽  
Antiviral Activity ◽  
Low Molecular Weight ◽  
Interferon Inducer

scholarly journals Lack of Effect of an Interferon Inducer, N,N-Dihexadecyl-m-Xylylenediamine, on Rhinovirus Challenge in Humans

1979 ◽  
Vol 15 (2) ◽  
pp. 269-272 ◽  
Author(s):  
R. G. Douglas ◽  
R. H. Waldman ◽  
R. F. Betts ◽  
R. Ganguly
Keyword(s):  
Interferon Inducer

scholarly journals Effect of the preparation Ingavirin® (imidazolyl ethanamide pentandioic acid) on the interferon status of cells under conditions of viral infection

2016 ◽  
Vol 21 (4) ◽  
pp. 196-205
Author(s):  
Thomas Aschacher ◽  
Artem Krokhin ◽  
Irina Kuznetsova ◽  
Johannes Langle ◽  
Vladimir Nebolsin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Viral Infection ◽  
Viral Infections ◽  
Antiviral Drug ◽  
Effector Proteins ◽  
Theoretical Ground ◽  
Ns1 Protein ◽  
Interferon Inducer ◽  
Infected Cells ◽  
Interferon System

Ingavirin® (imidazolyl ethanamide pentandioic acid) is an original antiviral drug, which is used in Russia for treatment and profilaxis of influenza and other acute viral infections. We confirmed that imidazolyl ethanamide pentandioic acid (IEPA), not being interferon inducer itself, enhances synthesis of both interferon-a/fi receptors (IFNAR) to interferone and cell sensitivity to interferone signalling, which was suppressed by NS1 protein - pathogen factor of influenza virus. IEPA is able to promote antiviral effector proteins PKR and MxA in infected cells, in opposition to interferon system suppression by influenza virus. Theoretical ground of clinical efficacy of Ingavirine® could be confirmed by obtained data of influence to innate immune system during viral infection.

scholarly journals Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model

Virology ◽  
2007 ◽  
Vol 360 (2) ◽  
pp. 454-460 ◽  
Author(s):  
Justin G. Julander ◽  
Venkatraman Siddharthan ◽  
Lawrence M. Blatt ◽  
Kristiina Schafer ◽  
Robert W. Sidwell ◽  
...  
Keyword(s):  
Virus Disease ◽  
Encephalitis Virus ◽  
Interferon Inducer ◽  
Hamster Model ◽  
Equine Encephalitis Virus ◽  
Western Equine Encephalitis Virus ◽  
Western Equine Encephalitis

Old Tuberculin Associated with Liposomes: A New Interferon Inducer

1982 ◽  
Vol 2 (2) ◽  
pp. 187-194 ◽  
Author(s):  
GARY R. BURLESON ◽  
CHARLES F. KULPA ◽  
FLORENCE GERMAIN-DE MATTEIS
Keyword(s):  
Interferon Inducer
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