Sodium houttuynia alleviates airway inflammation in asthmatic mice by regulating FoxP3/RORγT expression and reversing Treg/Th17 cell imbalance

2022 ◽  
Vol 103 ◽  
pp. 108487
Author(s):  
Chao Wang ◽  
Chen-Feng Huang ◽  
Miao Li
Keyword(s):  
Airway Inflammation ◽  
Th17 Cell

Role of IL-23-Th17 Cell Axis in Allergic Airway Inflammation

2009 ◽  
Vol 149 (1) ◽  
pp. 108-112 ◽  
Author(s):  
Hidefumi Wakashin ◽  
Koichi Hirose ◽  
Itsuo Iwamoto ◽  
Hiroshi Nakajima
Keyword(s):  
Airway Inflammation ◽  
Th17 Cell ◽  
Allergic Airway Inflammation ◽  
Cell Axis

Glutathione Peroxidase 1 Deficiency Attenuates Allergen-Induced Airway Inflammation by Suppressing Th2 and Th17 Cell Development

2010 ◽  
Vol 13 (5) ◽  
pp. 575-587 ◽  
Author(s):  
Hee Yeon Won ◽  
Jung Ho Sohn ◽  
Hyun Jung Min ◽  
Kihyun Lee ◽  
Hyun Ae Woo ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Airway Inflammation ◽  
Th17 Cell ◽  
Cell Development ◽  
Glutathione Peroxidase 1

scholarly journals γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Weixi Zhang ◽  
Xueya Zhang ◽  
Anqun Sheng ◽  
Cuiye Weng ◽  
Tingting Zhu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Mouse Model ◽  
Notch Signaling ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Th17 Cell ◽  
Clinical Signs ◽  
T Helper 17 ◽  
Th17 Cell Differentiation ◽  
Secretase Inhibitor

T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling.γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. The aim of this study was to evaluate the effect of GSI on Th17 cell differentiation in a mouse model of allergic asthma. OVA was used to induce mouse asthma model in the presence and absence of GSI. GSI ameliorated the development of OVA-induced asthma, including suppressing airway inflammation responses and reducing the severity of clinical signs. GSI also significantly suppressed Th17-cell responses in spleen and reduced IL-17 levels in serum. These findings suggest that GSI directly regulates Th17 responses through a Notch signaling-dependent pathway in mouse model of allergic asthma, supporting the notion that GSI is a potential therapeutic agent for the treatment of allergic asthma.

Sign in / Sign up

Export Citation Format

Share Document