scholarly journals A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system

iScience ◽  
2021 ◽  
pp. 102678
Author(s):  
Duomeng Yang ◽  
Tao Lin ◽  
Cen Li ◽  
Andrew G. Harrison ◽  
Tingting Geng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Virus Infection ◽  
Vesicular Stomatitis Virus ◽  
Critical Role ◽  
The Central Nervous System ◽  
Vesicular Stomatitis

scholarly journals Immune Response in the Absence of Neurovirulence in Mice Infected with M Protein Mutant Vesicular Stomatitis Virus

2008 ◽  
Vol 82 (18) ◽  
pp. 9273-9277 ◽  
Author(s):  
Maryam Ahmed ◽  
Tracie R. Marino ◽  
Shelby Puckett ◽  
Nancy D. Kock ◽  
Douglas S. Lyles
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Vesicular Stomatitis Virus ◽  
M Protein ◽  
Wild Type ◽  
Protein Mutants ◽  
The Central Nervous System ◽  
Vesicular Stomatitis

ABSTRACT Matrix (M) protein mutants of vesicular stomatitis virus (VSV), such as rM51R-M virus, are less virulent than wild-type (wt) VSV strains due to their inability to suppress innate immunity. Studies presented here show that when inoculated intranasally into mice, rM51R-M virus was cleared from nasal mucosa by day 2 postinfection and was attenuated for spread to the central nervous system, in contrast to wt VSV, thus accounting for its reduced virulence. However, it stimulated an antibody response similar to that in mice infected with the wt virus, indicating that it has the ability to induce adaptive immunity in vivo without causing disease. These results support the use of M protein mutants of VSV as vaccine vectors.

scholarly journals Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responses

Virology ◽  
2010 ◽  
Vol 400 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Vinita S. Chauhan ◽  
Samantha R. Furr ◽  
David G. Sterka ◽  
Daniel A. Nelson ◽  
Megan Moerdyk-Schauwecker ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Vesicular Stomatitis Virus ◽  
Inflammatory Responses ◽  
The Central Nervous System ◽  
Vesicular Stomatitis

Detection of vesicular stomatitis virus (VSV) RNA in the central nervous system of infected mice by in situ hybridization

1988 ◽  
Vol 75 (6) ◽  
pp. 554-556 ◽  
Author(s):  
J. G. Fournier ◽  
O. Robain ◽  
I. Cerutti ◽  
I. Tardivel ◽  
F. Chany-Fournier ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Situ Hybridization ◽  
Vesicular Stomatitis Virus ◽  
The Central Nervous System ◽  
Vesicular Stomatitis
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