Instrumental assessment of atopic eczema: Validation of transepidermal water loss, stratum corneum hydration, erythema, scaling, and edema

2006 ◽  
Vol 55 (5) ◽  
pp. 772-780 ◽  
Author(s):  
Elisabeth A. Holm ◽  
Hans C. Wulf ◽  
Lars Thomassen ◽  
Gregor B.E. Jemec
Keyword(s):  
Stratum Corneum ◽  
Atopic Eczema ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Instrumental Assessment ◽  
Stratum Corneum Hydration

Beneficial effects of oral supplementation with ferulic acid, a plant phenolic compound, on the human skin barrier in healthy men

2021 ◽  
pp. 1-7
Author(s):  
Atsushi Suzuki ◽  
Tomoko Nomura ◽  
Hiroko Jokura ◽  
Naoya Kitamura ◽  
Akihiko Fujii ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Stratum Corneum ◽  
Water Loss ◽  
Nervous Activity ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Sympathetic Nervous Activity ◽  
Healthy Men ◽  
Stratum Corneum Hydration ◽  
Sympathetic Nervous

Abstract. Ferulic acid (FA) is a phytochemical compound with various physiologic functions. To clarify the effect of FA intake on skin barrier function (SBF), we conducted a placebo-controlled double-blind pilot trial. Sixteen healthy subjects were divided into 2 groups (n = 8) and ingested capsules containing either FA (200 mg) or placebo daily for 2 weeks. Two measures of SBF, transepidermal water loss and stratum corneum hydration, were assessed before and 2 weeks after the start of the study. Autonomic nervous activity, which is suggested to be related to SBF, was also measured. Compared with the values obtained before the start of the study, FA intake significantly reduced transepidermal water loss (from 6.1 ± 1.1 to 4.8 ± 1.0 g/m2/h, p = 0.005) and increased stratum corneum hydration (from 30.1 ± 7.6 to 32.3 ± 8.1 a.u., p = 0.027) after 2 weeks. In addition, the amount change in sympathetic nervous activity was significantly reduced after ingesting the FA capsules compared with the placebo capsules (−0.7 ± 1.6 vs. 1.1 ± 1.4, p = 0.035). These findings suggest that FA supplementation decreases sympathetic nervous activity and strengthens SBF in healthy men.

Effect of sock type on foot health

2019 ◽  
Vol 89 (18) ◽  
pp. 3871-3881 ◽  
Author(s):  
Rebecca Van Amber ◽  
Raechel M Laing ◽  
Cheryl A Wilson ◽  
Linda A Dunn ◽  
Tim Jowett
Keyword(s):  
Diabetes Mellitus ◽  
Stratum Corneum ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Fiber Content ◽  
Foot Health ◽  
Merino Wool ◽  
Stratum Corneum Hydration ◽  
Structure Changes ◽  
Over Time

The objective was to determine whether changes in indicators of skin health among participants suffering from diabetes mellitus could be attributable to the type of sock worn (fiber content, structure). Changes in skin health over time (e.g. temperature, skin hardness, transepidermal water loss, stratum corneum hydration) can indicate improvement or deterioration, and these may be related to socks worn. Socks of different structure (single jersey, terry), and of fiber content (merino wool, cotton) were worn over a period of 22 weeks by participants suffering from diabetes mellitus. Each participant was their own control: change over time in skin hardness, stratum corneum hydration, transepidermal water loss and temperatures were monitored. Properties of the sock fabrics were measured as new and after use to determine effects of wear. Limited evidence of improved skin health was attributable to socks composed primarily of wool.

scholarly journals Aging-like physiological changes in the skin of Japanese obese diabetic patients

2018 ◽  
Vol 6 ◽  
pp. 205031211875666 ◽  
Author(s):  
Ai Ibuki ◽  
Shoko Kuriyama ◽  
Yukiko Toyosaki ◽  
Misaki Aiba ◽  
Moeko Hidaka ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Advanced Glycation End Products ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Advanced Glycation ◽  
Diabetes Group ◽  
Stratum Corneum Hydration ◽  
Glycation End Products ◽  
End Products ◽  
Dermal Collagen

Objective: Obesity-associated diabetes causes aging-like changes to skin physiology in animal models, but there have been no clinical studies focusing on human obese diabetic patients. The purpose of this study was to examine the hypothesis that obesity-associated diabetes accelerates aging-like skin changes in Japanese people. Methods: This cross-sectional study enrolled obese-diabetes patients (body mass index ≥ 25 kg m−2) and healthy volunteers (body mass index < 25 kg m−2) as controls. Skin physiology parameters relating to aging (stratum corneum hydration, transepidermal water loss, skin pH, advanced glycation end-products, and dermal collagen density) were evaluated in the two groups. Results: About 37 subjects participated (16 in a control group and 21 in an obese-diabetes group). Age was not significantly different between the groups. The stratum corneum hydration level was significantly lower in the obese-diabetes group. Transepidermal water loss and levels of advanced glycation end-products were significantly higher in this group. Skin pH was not significantly different between groups. Dermal collagen density decreased in the obese-diabetes group. Conclusion: We showed that obese-diabetes patients have decreased stratum corneum hydration, increased transepidermal water loss, higher skin advanced glycation end-products and decreased dermal collagen fiber density compared with normal-weight subjects. These results indicate that the ordinary age-related physiological skin changes seen in the elderly can also occur in obese-diabetes patients aged in their 40s.

Sign in / Sign up

Export Citation Format

Share Document