EVALUATION OF ANTI-GLYCATION EFFECT AND SAFETY OF SERUM ANTI-AGING FORMULATION CONTAINING GOLD NANOPARTICLES (AUNP) USING SIDAGURI EXTRACT (SIDA RHOMBIFOLIA)

Objective: The purpose of this study is to determine the anti-aging properties and safety of serum containing gold nanoparticles (AuNP) using Sidaguri extract (Sida rhombifolia) through their anti-glycation effect. Methods: The anti-aging effect of serum was performed in vitro by measuring advance glycation end products (AGEs) formed during incubation using a Microplate reader, and safety of serum was performed using hen’s egg chorioallantoic membrane (HET-CAM) method using White Leghorn egg. Results: The study showed that serum formulation had an anti-glycation effect with inhibition percentages are 68.20±6.86% and 74.83%±19.91% for a serum containing 10% and 20% gold nanoparticles and little to no irritation potency for both serum formulations with RI value 0.0 and 0.0, respectively. Conclusion: Due to both their anti-glycation effect and irritation behavior, serum formulation containing gold nanoparticle synthesized using Sidaguri extracts could be utilized as anti-aging cosmetics in the future.

Microwave Heating as an Innovative Road Maintenance Technology: Aging Effect on Binder and Feasibility Evaluation

The microwave heating/healing technique is regarded as a green maintenance approach for asphalt pavements thanks to its promising environmental and economic benefits. However, the main concern about this technology is represented by the possible aging effect generated on bituminous binders. Currently, there is a significant lack of studies dealing with this topic. Based on these premises, the main purpose of this study is to appraise the feasibility of implementing microwave-based maintenance operations considering the associated aging effect. The assessment of fatigue life after cyclic microwave heating (MH) based on a linear amplitude sweep (LAS) test and the changes in the chemical groups detected through Fourier transform infrared (FTIR) spectroscopy document the aging phenomenon. The results indicate that the microwave aging degree on bituminous binder is nonlinear with MH cycles. The microwave radiation causes a distinct aging impact on binders during the first 10 cycles, then the values become constant. Furthermore, a feasibility analysis of MH technology is developed, encompassing four main multidisciplinary aspects: evaluation of microwave aging degree, working mechanism of MH equipment, safety assessment, and economic and ecological considerations. Despite the associated aging issue, the MH method is an efficient technology, considering its various advantages (i.e., rapidity of execution, uniform and non-pollutant treatment, and deep penetration). Meanwhile, the use of steel slag as a microwave absorber bolsters the sustainability of MH technology. This study provides a new perspective to evaluate the microwave heating technique in road engineering comprising the generated aging effect. Practice-oriented recommendations are also formulated regarding the safe implementation of MH technical operations.

Hygrothermal aging effect on the properties of PMMA nanocomposites reinforced by ceramic nanoparticles

This paper aimed to evaluate hygrothermal aging effects on polymethyl methacrylate modified with TiO2, SiO2, and Al2O3 nanoparticles in 0.5, 1, and 2% weight fractions. The distribution of nanoparticles was characterized by the scanning electron microscopy (SEM) method. Moisture absorption behavior and mechanical properties of samples in terms of elastic modulus, tensile strength, impact strength, and hardness were investigated. Furthermore, the coefficient of hygrothermal expansion (CHE) for each sample was calculated thanks to experimental data. Finally, by applying the multi-criteria decision making (MCDM) technique, the optimum composition for superior performance was obtained in 0.5 wt% of nanoparticles, more specifically for SiO2.

Anti-aging Effect of Mixed Extract from Medicinal Herbs

Purpose: This study was conducted to confirm the applicability of a mixed herbal extract (MHE) as an anti-aging cosmetic ingredient by investigating its skin anti-aging activities in vitro and in vivo.Methods: In this study, we prepared MHE using an ultrasonic extraction containing Forsythiae fructus, Tribuli fructus, Solomon’s seal, Siberian ginseng, Ponciri fructus and Ginseng. We investigated the anti-aging effect of the MHE for skin in dermal fibroblasts. The anti-aging activity was determined by the type I collagen synthesis levels. Matrix metalloproteinase-1 (MMP1) and tissue inhibitor of metalloproteinases 1 (TIMP1) mRNA levels were measured by qRT-PCR. MMP1 protein levels were evaluated by blotting analysis. Clinical tests of skin moisture, elasticity, texture, and wrinkles were performed using cosmetics containing 1% MHE.Results: The MHE induced the upregulation of pro-collagen type I synthesis and TIMP1 mRNA expression. The MHE led to the downregulation of MMP1 mRNA levels and protein levels. Furthermore, after skin application of cosmetics containing 1% MHE, skin hydration, elasticity, texture, and crow’s feet were improved 4 weeks after the treatment.Conclusion: MHE has an anti-aging effect by promoting collagen synthesis and suppressing MMP1 gene expression in vitro, and it has a skin improvement effect in vivo. Therefore, the MHE was shown to have value as a functional cosmetic ingredient.