Chromoblastomycosis: A good treatment response to itraconazole combined with terbinafine

2011 ◽  
Vol 64 (2) ◽  
pp. AB107
Keyword(s):  
Treatment Response ◽  
Good Treatment ◽  
Good Treatment Response

scholarly journals Aggressive Multimodal Approach for Anaplastic Thyroid Cancer and Long-Term Survival

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Nasir Hussain ◽  
Usman Mustafa ◽  
Su Hyeon Jung ◽  
Alan D. Gilman
Keyword(s):  
Thyroid Cancer ◽  
Survival Rate ◽  
Treatment Response ◽  
Radiation Treatment ◽  
Anaplastic Thyroid Cancer ◽  
Muscle Layer ◽  
Good Treatment ◽  
Multimodal Approach ◽  
Term Survival ◽  
Good Treatment Response

Anaplastic thyroid cancer (ATC) comprises 1-2% of all thyroid cancers and is one of the most aggressive cancers with a median survival rate of around four months. The average 5-year survival rate has been reported to be around 3.6%. In this paper, we have discussed management and prognostic variables of a patient with ATC who has survived for more than 5 years. A 59-year-old female was referred to our facility for an elective thyroid and parathyroidectomy for concerns of thyroid papillary cancer and hyperparathyroidism. At the time of surgery, the tumor mass had invaded the muscular layer of esophagus; radicle thyroidectomy parathyroidectomy along with removal of muscle layer of esophagus was performed, and diagnosis of ATC was made. The patient was treated with chemoradiation with a good treatment response and no recurrence of tumor for two and a half years until PET/CT followed by wedge biopsy of lung confirmed ATC recurrence. The patient was treated with another course of radiation treatment with a good treatment response. Since then, the patient has been following in our outpatient oncology clinic and has no evidence of tumor recurrence. Aggressive multimodal approach of combining radicle surgery with chemoradiation treatment in select patients of ATC with no distant metastasis helps improve prognosis.

scholarly journals Adolescents’ experiences of brief psychosocial intervention for depression: An interpretative phenomenological analysis of good-outcome cases

2019 ◽  
Vol 25 (1) ◽  
pp. 106-118
Author(s):  
Darshita Dhanak ◽  
Lisa Thackeray ◽  
Bernadka Dubicka ◽  
Raphael Kelvin ◽  
Ian M Goodyer ◽  
...  
Keyword(s):  
Psychosocial Intervention ◽  
Interpretative Phenomenological Analysis ◽  
Adolescent Depression ◽  
Controlled Trial ◽  
Clinical Effectiveness ◽  
Phenomenological Analysis ◽  
Good Treatment ◽  
Good Outcome ◽  
Novel Approach ◽  
Good Treatment Response

Background: Brief psychosocial intervention (BPI) is a treatment for adolescent depression that has recently demonstrated clinical effectiveness in a controlled trial. The aim of this study is to explore experiences of adolescents with major depression receiving BPI treatment in the context of good treatment outcomes. Method: A subsample of five interviews from a larger study of adolescents’ experiences of BPI was purposively selected, focusing on good-outcome cases. Interviews were analysed using interpretative phenomenological analysis to provide a richer understanding of participants’ experiences of overcoming depression in the BPI group. Results: Four central themes were identified: ‘Being heard and feeling safe’, ‘Collaborative working enhancing therapy’, ‘Gaining a different perspective on one’s self and relationships’ and ‘A positive therapeutic relationship’. Conclusion: BPI is a novel approach with promising clinical effectiveness. Utilising adolescents’ experiences has revealed potential psychological mechanisms of good treatment response to BPI. Overall implications for clinical practice with depressed adolescents are discussed.

scholarly journals MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response

2018 ◽  
Vol 4 (3) ◽  
pp. 205521731878782 ◽  
Author(s):  
Lekha Pandit ◽  
Sharik Mustafa ◽  
Ichiro Nakashima ◽  
Toshyuki Takahashi ◽  
Kimhiko Kaneko
Keyword(s):  
Optic Neuritis ◽  
Visual Impairment ◽  
Treatment Response ◽  
Clinical Course ◽  
Transverse Myelitis ◽  
Retinal Nerve Fibre Layer ◽  
Ganglion Cell Complex ◽  
Disease Heterogeneity ◽  
Asian Patients ◽  
Good Treatment Response

Objectives We investigated the clinical characteristics and treatment response in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease and looked for evidence of subclinical disease. Methods We prospectively evaluated the frequency and pattern of relapse, tested afferent visual function and monitored treatment response in 42 south Asian patients from a single centre. Results Eighteen patients (42.9%) had monophasic and 24 (57.1%) a relapsing course. Disease duration was longer ( P<0.02) in those with a relapsing course. Median time to the second attack was prolonged ( P<0.04) in patients with recurrent transverse myelitis when compared with neuromyelitis optica spectrum disorder and recurrent optic neuritis. Thirteen out of 17 patients (76.5%) initially presenting with optic neuritis developed recurrent optic neuritis later. After the first attack of transverse myelitis, 17 out of 22 (77.3%) had disease confined to the spinal cord. Optical coherence tomography detected peripapillary retinal nerve fibre layer thickness ( P<0.05) and macular ganglion cell complex volume ( P<0.005) abnormalities in seven out of 10 (70.0%) patients without clinical optic neuritis. Immunosuppressants induced remission in 17 out of 22 (77.3%) patients during a median follow-up of 48 months and the median Expanded Disability Status Score was 1 (range 1–10). Conclusion Our study highlighted the tendency for stereotypical attacks in MOG-IgG-associated disease, heterogeneity in clinical course among subtypes, subclinical visual impairment and the need for early and sustained immunosuppressive therapy.

scholarly journals Retrospective Study of Dupilumab Treatment for Moderate to Severe Atopic Dermatitis in Korea: Efficacy and Safety of Dupilumab in Real-World Practice

2020 ◽  
Vol 9 (6) ◽  
pp. 1982
Author(s):  
Dong Hyek Jang ◽  
Seok Jae Heo ◽  
Hye Jung Jung ◽  
Mi Yeon Park ◽  
Seong Jun Seo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Treatment Response ◽  
Real World ◽  
Eosinophil Count ◽  
Female Gender ◽  
Efficacy And Safety ◽  
The Real ◽  
Good Treatment Response

Among biological agents for the treatment of atopic dermatitis (AD), dupilumab is a front-runner. Although many studies have been conducted on the real-world use of dupilumab, the sample size is often small and data is primarily on Western people. Therefore, we investigated the efficacy and safety of dupilumab in patients with moderate-to-severe AD in Korea. All patients with moderate-to-severe AD treated with dupilumab from September 2018 to June 2019 in this institution were included and analyzed by medical records. They were evaluated using the Eczema Area and Severity Index (EASI), Numerical Rating Scale (NRS), Patient Oriented Eczema Measure (POEM), and Dermatology Quality of Life Index (DLQI), respectively on admission, after two weeks (only EASI and NRS) and after 16 weeks. Laboratory tests were measured before and 16 weeks after treatment. A total of 101 patients were included. All efficacy tools showed a significant decrease after 16 weeks; EASI 77.4%, NRS 70.0%, POEM 60.7%, and DLQI 65.0%. EASI was characterized by a marked improvement of 51.5% in just two weeks. The treatment response was not significantly different according to the interval of treatment. Elevated Lactate Dehydrogenase (LDH) at 16 weeks was associated with poor treatment response. Moreover, a high eosinophil count was related to a lower change in EASI and POEM. In the correlation analysis, EASI was not correlated to DLQI before treatment. For changes after 16 weeks, POEM showed the highest correlation with DLQI. (R = 0.66, p < 0.001) In the additional analysis for factors affecting treatment response, the female gender was associated with good treatment response. (odds ratio = 5.4, p = 0.04) Adverse events from treatment included facial erythema (9.9%) and conjunctivitis (5.0%). Overall, it was confirmed that the efficacy of dupilumab in the real-world is similar to that of the existing clinical trials. We suggest that POEM is a useful tool for identifying the quality of life. The female gender was associated with a good treatment response. Both an elevated LDH and a high eosinophil count could be a therapeutic biomarker. Further research will be needed for a long-term period.

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