Risk factors associated with first venous leg ulcer in a south Florida cohort – Early results demonstrate feasibility

2019 ◽  
Vol 81 (4) ◽  
pp. AB119
2019 ◽  
Vol 7 (1) ◽  
pp. 98-105 ◽  
Author(s):  
Raffi Melikian ◽  
Thomas F. O'Donnell ◽  
Luis Suarez ◽  
Mark D. Iafrati

1999 ◽  
Vol 135 (8) ◽  
Author(s):  
David J. Margolis ◽  
Jesse A. Berlin ◽  
Brian L. Strom

2019 ◽  
Vol 33 (7) ◽  
pp. 1241-1248 ◽  
Author(s):  
A.M. Meulendijks ◽  
F.M.C. de Vries ◽  
A.A. van Dooren ◽  
M.J. Schuurmans ◽  
H.A.M. Neumann

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023313 ◽  
Author(s):  
Joshua S Mervis ◽  
Robert S Kirsner ◽  
Hadar Lev-Tov

IntroductionChronic venous insufficiency (CVI) affects up to one-third of the adult population yet venous leg ulcers (VLU), a significant complication of CVI, only affect 1%–2% of adults in the USA. Why some develop VLU and others do not is unclear. VLU have a significant impact on quality of life and are extremely costly and difficult to treat. Moreover, VLU prevalence is increasing, doubling in the last 20 years. In order to characterise the differences between people with CVI and those who ultimately develop VLU, we aim to set up the unique venous insufficiency in South Florida cohort.Methods and analysisSubjects will be recruited from the University of Miami Hospital and Clinic’s vascular laboratory database, which began in July 2011. Any adult age 18–95 who has had venous reflux detected on duplex ultrasound of the lower extremities is included. Approximately 2500 patients are already in the database that meet these criteria, with an estimated 2500 additional potential subjects to be recruited from the vascular laboratory database over the next 5 years. Subjects with a history of VLU prior to the duplex study date will be excluded. Data will be collected via review of the Doppler study report, patient phone interview and review of the electronic medical record. Subjects will be contacted for follow-up every 3 months for at least 5 years until the study endpoint, development of first VLU (fVLU), is reached. In order to estimate the time from reflux documentation to fVLU, Kaplan-Meier survival curves will be constructed. Cox proportional hazard regression models will be constructed to investigate possible risk factors.Ethics and disseminationThis study is approved by the University of Miami’s Institutional Review Board. We hope to present the results of this study to the scientific community at conferences and in peer-reviewed journals.


Vascular ◽  
2005 ◽  
Vol 13 (3) ◽  
pp. 141-147 ◽  
Author(s):  
Lazar B. Davidovic ◽  
Ilijas S. Cinara ◽  
Tanja Ille ◽  
Dusan M. Kostic ◽  
Marko V. Dragas ◽  
...  

We sought to analyze the early results of civil and war peripheral arterial injury treatment and to identify risk factors associated with limb loss. Between 1992 and 2001, data collected retrospectively and prospectively on 413 patients with 448 peripheral arterial injuries were analyzed. Of these, there were 140 patients with war injuries and 273 patients with civil injuries. The mechanism of injury was gunshot in 40%, blunt injury in 24%, explosive trauma in 20.3%, and stabbing in 15.7% of the cases. The most frequently injured vessels were the femoral arteries (37.3%), followed by the popliteal (27.8%), axillary and brachial (23.5%), and crural arteries (6.5%). Associated injuries, which included bone, nerve, and remote injuries affecting the head, chest, or abdomen, were present in 60.8% of the cases. Surgery was carried out on all patients, with a limb salvage rate of 89.1% and a survival rate of 97.3%. In spite of a rising trend in peripheral arterial injuries, our total and delayed amputation rates remained stable. On statistical analysis, significant risk factors for amputation were found to be failed revascularization, associated injuries, secondary operation, explosive injury, war injury ( p < .01) and arterial contusion with consecutive thrombosis, popliteal artery injury, and late surgery ( p < .05). Peripheral arterial injuries, if inadequately treated, carry a high amputation rate. Explosive injuries are the most likely to lead to amputations, whereas stab injuries are the least likely to do so. The most significant independent risk factor for limb loss was failed revascularization.


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