Online Pearls: The Appearance or Disappearance of the Cornoid Lamella Due to Level and Direction of Sectioning in Porokeratosis

2020 ◽  
Author(s):  
Katie Tumminello ◽  
Caitlin A. Cochran ◽  
Robert T. Brodell
Keyword(s):  
Cornoid Lamella

Cornoid lamella in pachyonychia congenita

1978 ◽  
Vol 114 (12) ◽  
pp. 1795-1796 ◽  
Author(s):  
J. K. Wilkin
Keyword(s):  
Cornoid Lamella ◽  
Pachyonychia Congenita

scholarly journals Porokeratosis with an Invasive Squamous Cell Carcinoma: A Case Report and Review of Literature

2014 ◽  
Vol 32 (1) ◽  
pp. 31-36
Author(s):  
M Nessa ◽  
L Khondker ◽  
MA Bari ◽  
MSI Khan ◽  
M Rahman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Granular Layer ◽  
Malignant Degeneration ◽  
Invasive Squamous Cell Carcinoma ◽  
Review Of Literature ◽  
Large Plaque ◽  
Cornoid Lamella ◽  
Multiple Nodules

Porokeratosis is a clonal disorder of epidermal keratinization, which is characterized by hyperkeratotic papules or plaques that are surrounded by a thread-like elevated border. The histopathologic hallmark of porokeratosis is the cornoid lamella, which is a thin column of parakeratosis that overlies a thin or absent granular layer and that corresponds to the raised, hyperkeratotic border. Porokeratosis has five clinical types and malignant degeneration has been described in all forms of porokeratosis. We report a forty five year old farmer with a large plaque in chest for 30 years and multiple nodules within the large plaque for 2 years. A section of skin from margin of the plaque reveals histopathological features of porokeratosis and section from nodules reveals an invasive squamous cell carcinoma. To the best of our knowledge, this is the first reported case of porokeratosis transformed to squamous cell carcinoma on Bangladesh. DOI: http://dx.doi.org/10.3329/jbcps.v32i1.21035 J Bangladesh Coll Phys Surg 2014; 32: 31-36

scholarly journals Genitogluteal porokeratosis - Case report

2013 ◽  
Vol 88 (3) ◽  
pp. 438-440 ◽  
Author(s):  
Flavia Regina Ferreira ◽  
Priscila Pacheco Lessa ◽  
Marcia Lanzoni de Alvarenga
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Cornoid Lamella

We report the case of a patient diagnosed with genitogluteal porokeratosis, a disorder of epidermal keratinization. The location described is extremely rare and very often late diagnosed or even misdiagnosed. Histopathology showed a typical cornoid lamella of great value to support this diagnosis. The importance of awareness of this entity by the specialist is emphasized as a differential diagnosis among genital diseases of chronic evolution and difficult treatment.

scholarly journals Postirradiation Multiple Minute Digitate Porokeratosis

2001 ◽  
Vol 5 (2) ◽  
pp. 126-130 ◽  
Author(s):  
Ramon M. Pujol ◽  
Eugenia Perez–Losada ◽  
Xavier Matias–Guiu ◽  
Josefina Fuentes ◽  
Carmen M. Alonso ◽  
...  
Keyword(s):  
Granular Layer ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Infiltrating Ductal Carcinoma ◽  
Anterior Aspect ◽  
Irradiation Therapy ◽  
Irradiation Field ◽  
Cornoid Lamella ◽  
Radiation Induced ◽  
The Right

Background: Development of multiple minute digitate hyperkeratoses (MMDH) after irradiation has been reported previously. The keratotic lesions in these cases were confined within the irradiation field, and histopathological examination disclosed a focal column of parakeratosis (cornoid lamella) arising from an epidermis devoid of granular layer. Objective: We describe a 78-year-old woman who developed multiple, discrete, tiny, filiform, keratotic papules on the anterior aspect of the right chest wall, 13 months after postmastectomy cobalt irradiation therapy for mammary infiltrating ductal carcinoma. Conclusion: Postirradiation MMDH represents a peculiar radiation-induced disorder that we believe should be distinguished from other cases of MMDH and included within the spectrum of porokeratosis.

Clinical and Dermoscopic Features of Pigmented Disseminated Superficial Actinic Porokeratosis: Case Report and Literature Review

2017 ◽  
Vol 22 (2) ◽  
pp. 229-231 ◽  
Author(s):  
Bahman Sotoodian ◽  
Muhammad N. Mahmood ◽  
Thomas G. Salopek
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Papillary Dermis ◽  
Case Presentation ◽  
Skin Tumour ◽  
Erythematous Papule ◽  
Clonal Proliferation ◽  
Disseminated Superficial Actinic Porokeratosis ◽  
Cornoid Lamella

Introduction: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally. Case Presentation: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin. Literature Review and Conclusion: A thorough review of PubMed failed to identify any previous reports on the dermoscopic appearance of pigmented porokeratosis. On dermoscopy, the presence of black dots limited to the periphery of the lesions is due to pigment incontinence and melanophages within the superficial papillary dermis limited to the area below the cornoid lamella. Pigmented DSAP is a unique morphological presentation of porokeratosis, and it is essential to be familiar with its clinical and dermoscopic presentation.

scholarly journals Coexist of Disseminated Superficial Actinic Porokeratosis and Porokeratosis Ptychotropica with A Novel MVK Gene Mutation: A Case Report and Literature Review

2021 ◽  
Author(s):  
Hongjun Xu ◽  
Linfeng Li
Keyword(s):  
Gene Mutation ◽  
Skin Lesions ◽  
Causative Mutation ◽  
Case Presentation ◽  
Disseminated Superficial Actinic Porokeratosis ◽  
Cornoid Lamella ◽  
Physical Examinations ◽  
Skin Biopsies ◽  
Porokeratosis Ptychotropica ◽  
Mvk Gene

Abstract Background: Porokeratosis is a rare, acquired or inherited disorder of keratinization. There are numerous clinical types of porokeratosis and they could coexist in one patient and in multiple members of an affected family. However, coexist of disseminated superficial actinic porokeratosis (DSAP) and porokeratosis ptychotropica (Ppt) is rare.Case presentation: A 45-year-old man presented with long-standing skin lesions. Physical examinations found numerous small, brown 2- to 4-mm patches on his face and several hyperkeratotic, verrucous plaques on his trunk and extremities. His father and one of his brothers also had similar lesions for years. Skin biopsies showed a cornoid lamella in the epidermis. And we identified c.155 G>A mutation of the mevalonate kinase (MVK) gene convertting a serine residue to asparagine (p.Ser52Asn) was the causative mutation for porokeratosis in this family. The clinicopathologic diagnosis of DSAP and Ppt with a novel MVK gene mutation was made. The hyperkeratotic plaques on the patient's scrotum were completely removed by microwave knife for more than 10 times. Conclusion: We report an unusual case of DSAP coexisting with Ppt and identified a novel MVK gene mutation in this patient's family. The microwave knife is an effective and safe therapy for porokeratosis.

scholarly journals Linear porokeratosis: a case report

2012 ◽  
Vol 4 (3) ◽  
pp. 105-112
Author(s):  
Slobodan Stojanović ◽  
Marina Jovanović ◽  
Nada Vučković ◽  
Siniša Tasić ◽  
Keyword(s):  
Clinical Case ◽  
Local Treatment ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Skin Carcinoma ◽  
Imiquimod Cream ◽  
Lines Of Blaschko ◽  
Cornoid Lamella ◽  
Co2 Laser Ablation ◽  
Timely Treatment

Abstract Porokeratosis is a rare genodermatosis based on chronic keratinization disorder histologically characterized by the presence of a cornoid lamella and various clinical manifestations. Five most commonly described types of poroketarosis are porokeratosis of Mibelli or ”classic” porokeratosis, disseminated superfi cial actinic porokeratosis, disseminated palmoplantar porokeratosis, linear porokeratosis, and punctate porokeratosis. In all of the fi ve clinical types of porokeratosis described today, cases of planocellular skin carcinoma are described, except in punctate type cases. Use of topical CO2 laser ablation, cryotherapy and topical use of 5% Imiquimod cream, have shown favorable effects in local treatment of porokeratosis. The authors present a clinical case of a girl suffering from linear porokeratosis over the course of the last four years, spreading on the inside of her right arm along the lines of Blaschko. Linear porokeratosis was histologically confi rmed by biopsy of skin lesions and dermoscopy. Dermoscopic fi ndings, used as an auxiliary method, also indicated linear porokeratosis. Successful liquid nitrogen cryotherapy prompted the authors to present a case in which the applied treatment proved to be successful, but also to emphasize the need for timely treatment in order to prevent malignant alterations of these changes.

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