scholarly journals TCT-369 Long Term Clinical Outcome and Routine Angiographic Follow-up After Successful Recanalization of Complex True Chronic Total Coronary Occlusion With a Long Stenting Length. A Single Centre Experience

2013 ◽  
Vol 62 (18) ◽  
pp. B116 ◽  
Author(s):  
Karl Isaaz ◽  
Antoine Gerbay ◽  
Norbert Mayaud ◽  
Mohamed H. Sabry ◽  
Laure Richard ◽  
...  
Author(s):  
E. Sala ◽  
G. Carosi ◽  
G. Del Sindaco ◽  
R. Mungari ◽  
A. Cremaschi ◽  
...  

Abstract Purpose A long-lasting remission of acromegaly after somatostatin analogues (SAs) withdrawal has been described in some series. Our aim was to update the disease evolution after SAs withdrawal in a cohort of acromegalic patients. Methods We retrospectively evaluated 21 acromegalic patients previously included in a multicentre study (Ronchi et al. 2008), updating data at the last follow-up. We added further 8 patients selected for SAs withdrawal between 2008–2018. Pituitary irradiation represented an exclusion criterion. The withdrawal was suggested after at least 9 months of clinical and hormonal disease control. Clinical and biochemical data prior and after SAs withdrawal were analysed. Results In the whole cohort (29 patients) mean age was 50 ± 14.9 years and 72.4% were females. In 69% pituitary surgery was previously performed. Overall, the median time of treatment before SAs withdrawal was 53 months (IQR = 24–84). At the last follow up in 2019, 23/29 patients (79.3%) had a disease relapse after a median time of 6 months (interquartile range or IQR = 3–12) from the drug suspension, while 6/29 (20.7%) were still on remission after 120 months (IQR = 66–150). IGF-1 levels were significantly lower before withdrawal in patients with persistent remission compared to relapsing ones (IGF-1 SDS: -1.5 ± 0.6 vs -0.11 ± 1, p = 0.01). We did not observe any other difference between patients with and without relapse, including SAs formulation, dosage and treatment duration. Conclusion A successful withdrawal of SAs is possible in a subset of well-controlled acromegalic patients and it challenges the concept that medical therapy is a lifelong requirement.


2018 ◽  
Vol 27 ◽  
pp. S493
Author(s):  
B. Khialani ◽  
C. Jaworski ◽  
C. Hiew ◽  
M. Sebastian

2014 ◽  
Vol 64 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Sudhakar George ◽  
James Cockburn ◽  
Tim C. Clayton ◽  
Peter Ludman ◽  
James Cotton ◽  
...  

2014 ◽  
Vol 47 (1) ◽  
pp. 159-167 ◽  
Author(s):  
David Kalfa ◽  
Siamak Mohammadi ◽  
Dimitri Kalavrouziotis ◽  
Mounir Kharroubi ◽  
Daniel Doyle ◽  
...  

2018 ◽  
Vol 28 (8) ◽  
pp. 1001-1008 ◽  
Author(s):  
Madhukar S. Kollengode ◽  
Curt J. Daniels ◽  
Ali N. Zaidi

AbstractLapses in care during transition in adult CHD patients lead to increased morbidity and mortality. Previous studies have investigated predictors of poor follow-up in universal healthcare paradigms and select American populations. We studied patients with a wide spectrum of CHD severity within a single American centre to identify factors associated with successful internal transition and maintenance of care. Loss of follow-up was defined as no documented cardiac follow-up for ⩾3 years. Ambulatory cardiology patients aged 16–17 years with CHD were retrospectively enrolled and contacted. A survey assessing demographics, patients’ understanding of their CHD, medical status, and barriers to care was administered. On the basis of chart review of 197 enrolled patients, 74 demonstrated loss of follow-up (37.6%). Of 78 successfully contacted patients, 58 were surveyed, of whom a minority had loss of follow-up (n=16). The status of most patients with loss of follow-up was not known. Maintenance of care was associated with greater complexity of CHD (p<0.01), establishment of care with an adult CHD provider (p<0.001), use of prescription medications (p<0.001), and receipt of education emphasising the importance of long-term cardiac care (p<0.003). Insurance lapses were not associated with loss of follow-up (p=0.08). Transition and maintenance of care was suboptimal even within a single centre. Over one-third of patients did not maintain care. Patients with greater-complexity CHD, need for medications, receipt of transition education, and care provided by adult CHD providers had superior follow-up.


Heart ◽  
2014 ◽  
Vol 100 (Suppl 3) ◽  
pp. A3.2-A4 ◽  
Author(s):  
Sandhya Santharam ◽  
Maria Theodosiou ◽  
Sara Thorne ◽  
Paul Clift ◽  
Lucy Hudsmith ◽  
...  

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