scholarly journals TCT-26 Recanalization of Chronic Total Occlusions in Patients with vs. without Chronic Kidney Disease: the Impact of Contrast-Induced Acute Kidney Injury

2018 ◽  
Vol 72 (13) ◽  
pp. B12
Author(s):  
Lorenzo Azzalini ◽  
Soledad Ojeda ◽  
Ozan Demir ◽  
Joseph Dens ◽  
Masaki Tanabe ◽  
...  
Nephron ◽  
2018 ◽  
Vol 139 (3) ◽  
pp. 254-268 ◽  
Author(s):  
Sung Yoon Lim ◽  
Yoon Sook Ko ◽  
Hee Young Lee ◽  
Ji Hyun Yang ◽  
Myung Gyu Kim ◽  
...  

2018 ◽  
Vol 34 (3) ◽  
pp. 493-501 ◽  
Author(s):  
Maxwell D Leither ◽  
Daniel P Murphy ◽  
Luke Bicknese ◽  
Scott Reule ◽  
David M Vock ◽  
...  

2017 ◽  
Vol 126 (1) ◽  
pp. 39-46 ◽  
Author(s):  
David Legouis ◽  
Pierre Galichon ◽  
Aurélien Bataille ◽  
Sylvie Chevret ◽  
Sophie Provenchère ◽  
...  

Abstract Background There is recent evidence to show that patients suffering from acute kidney injury are at increased risk of developing chronic kidney disease despite the fact that surviving tubular epithelial cells have the capacity to fully regenerate renal tubules and restore renal function within days or weeks. The aim of the study was to investigate the impact of acute kidney injury on de novo chronic kidney disease. Methods The authors conducted a retrospective population-based cohort study of patients initially free from chronic kidney disease who were scheduled for elective cardiac surgery with cardiopulmonary bypass and who developed an episode of acute kidney injury from which they recovered. The study was conducted at two French university hospitals between 2005 and 2015. These individuals were matched with patients without acute kidney injury according to a propensity score for developing acute kidney injury. Results Among the 4,791 patients meeting the authors’ inclusion criteria, 1,375 (29%) developed acute kidney injury and 685 fully recovered. Propensity score matching was used to balance the distribution of covariates between acute kidney injury and non- acute kidney injury control patients. Matching was possible for 597 cases. During follow-up, 34 (5.7%) had reached a diagnosis of chronic kidney disease as opposed to 17 (2.8%) in the control population (hazard ratio, 2.3; bootstrapping 95% CI, 1.9 to 2.6). Conclusions The authors’ data consolidate the recent paradigm shift, reporting acute kidney injury as a strong risk factor for the rapid development of chronic kidney disease.


Author(s):  
John R. Prowle ◽  
Lui G. Forni ◽  
Max Bell ◽  
Michelle S. Chew ◽  
Mark Edwards ◽  
...  

AbstractPostoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease and diabetes mellitus. PO-AKI is best defined as AKI occurring within 7 days of an operative intervention using the Kidney Disease Improving Global Outcomes (KDIGO) definition of AKI; however, additional prognostic information may be gained from detailed clinical assessment and other diagnostic investigations in the form of a focused kidney health assessment (KHA). Prevention of PO-AKI is largely based on identification of high baseline risk, monitoring and reduction of nephrotoxic insults, whereas treatment involves the application of a bundle of interventions to avoid secondary kidney injury and mitigate the severity of AKI. As PO-AKI is strongly associated with long-term adverse outcomes, some form of follow-up KHA is essential; however, the form and location of this will be dictated by the nature and severity of the AKI. In this Consensus Statement, we provide graded recommendations for AKI after non-cardiac surgery and highlight priorities for future research.


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