Challenge with environmental tobacco smoke exacerbates allergic airway disease in human beings

2006 ◽  
Vol 118 (2) ◽  
pp. 441-446 ◽  
Author(s):  
David Diaz-Sanchez ◽  
Robert Rumold ◽  
Henry Gong Jr.
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Human Beings

Effect of Allergens and Tobacco Smoke on Laryngeal Mucosa

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P96-P96
Author(s):  
Peter C Belafsky ◽  
Debbie A. Mouadeb ◽  
Kent Pinkerton ◽  
Martin A Birchall ◽  
Thomas Konia
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Airway Disease ◽  
Second Hand Smoke ◽  
Lower Airway ◽  
House Dust Mite Allergen ◽  
Markers Of Inflammation ◽  
Laryngeal Mucosa ◽  
Chronic Laryngitis ◽  
Dust Mite Allergen

Problem Environmental factors such as second hand smoke and allergens are known to play an important part in the development of lower airway disease, specifically asthma. The effect of these common exposures on the larynx has been neglected. The purpose of this investigation was to investigate the effects of environmental tobacco smoke (ETS) and allergens on laryngeal mucosa. Methods Seventeen guinea pigs were exposed by inhalation to: 1) air and saline, 2) air and house dust mite allergen (HDMA), 3) ETS and saline 4) HDMA and ETS. Exposures began at 3 weeks of age and lasted 10 weeks. Histology was evaluated in different subsets of the larynx for eosinophils and mucin, markers of inflammation. Results Eosinophils in the supraglottis were elevated in the air/HDMA and ETS/HDMA groups (p<0.05). Animals exposed to HDMA were 4 times more likely to have > 10 eosinophils per HPF in the supraglottis than control animals (95% CI = 0.74, 20). Trends towards mucin hypersecretion in the subglottis of the ETS/air and ETS/HDMA groups were noted. Animals exposed to ETS and HDMA were 3.8 times more likely to have 25% of the subglottic epithelium stain PAS positive for mucin (95% CI = .59, 23.66). Conclusion The data suggest that environmental tobacco smoke and inhaled allergens contribute to the pathogenesis of laryngeal inflammation. Significance Environmental tobacco smoke and allergen exposure may play a role in the development of chronic laryngitis.

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