scholarly journals Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization

2017 ◽  
Vol 140 (2) ◽  
pp. 593-595.e3 ◽  
Author(s):  
Catherine A. Steer ◽  
Itziar Martinez-Gonzalez ◽  
Maryam Ghaedi ◽  
Patricia Allinger ◽  
Laura Mathä ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Cell Activation ◽  
Innate Lymphoid Cell ◽  
Allergen Sensitization ◽  
Type 2 Immunity ◽  
Neonatal Lung ◽  
Group 2

scholarly journals A critical role for c‐Myc in group 2 innate lymphoid cell activation

Allergy ◽  
2020 ◽  
Vol 75 (4) ◽  
pp. 841-852 ◽  
Author(s):  
Longyun Ye ◽  
Jiexue Pan ◽  
Mingwei Liang ◽  
Muhammad Asghar Pasha ◽  
Xiaofei Shen ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Cell Activation ◽  
Critical Role ◽  
Innate Lymphoid Cell ◽  
Group 2

scholarly journals Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

2013 ◽  
Vol 5 (174) ◽  
pp. 174ra26-174ra26 ◽  
Author(s):  
C. Barnig ◽  
M. Cernadas ◽  
S. Dutile ◽  
X. Liu ◽  
M. A. Perrella ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Lymphoid Cell ◽  
Cell Activation ◽  
Killer Cell ◽  
Innate Lymphoid Cell ◽  
Lipoxin A4

scholarly journals Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

2019 ◽  
Vol 143 (6) ◽  
pp. 2202-2214.e5 ◽  
Author(s):  
Jovana Maric ◽  
Avinash Ravindran ◽  
Luca Mazzurana ◽  
Aline Van Acker ◽  
Anna Rao ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Cell Activation ◽  
Prostaglandin D2 ◽  
Human Group ◽  
Innate Lymphoid Cell ◽  
Endogenous Production ◽  
Group 2

scholarly journals Pathways to limit group 2 innate lymphoid cell activation

2017 ◽  
Vol 139 (5) ◽  
pp. 1465-1467 ◽  
Author(s):  
Taylor A. Doherty ◽  
David H. Broide
Keyword(s):  
Lymphoid Cell ◽  
Cell Activation ◽  
Innate Lymphoid Cell ◽  
Limit Group ◽  
Group 2

scholarly journals Tumor suppressor p53 regulates intestinal type 2 immunity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chun-Yuan Chang ◽  
Jianming Wang ◽  
Yuhan Zhao ◽  
Juan Liu ◽  
Xue Yang ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Critical Role ◽  
Intestinal Type ◽  
Parasitic Infections ◽  
Nippostrongylus Brasiliensis ◽  
Innate Lymphoid Cell ◽  
Type 2 Immunity ◽  
Tuft Cell

AbstractThe role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca2+ influx and IL-25 release, which are critical triggers of type 2 innate lymphoid cell response. Our results thus reveal a previously unrecognized function of p53 in regulating intestinal type 2 immunity to protect against parasitic infections, highlighting the role of p53 as a guardian of immune integrity.

scholarly journals Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

Immunity ◽  
2015 ◽  
Vol 43 (1) ◽  
pp. 161-174 ◽  
Author(s):  
Ari B. Molofsky ◽  
Frédéric Van Gool ◽  
Hong-Erh Liang ◽  
Steven J. Van Dyken ◽  
Jesse C. Nussbaum ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Cell Activation ◽  
Interferon Γ ◽  
Innate Lymphoid Cell ◽  
Interleukin 33 ◽  
Group 2
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