scholarly journals Safety and effectiveness of continuation antidepressant versus mood stabilizer monotherapy for relapse-prevention of bipolar II depression: A randomized, double-blind, parallel-group, prospective study

2015 ◽  
Vol 185 ◽  
pp. 31-37 ◽  
Author(s):  
Jay D. Amsterdam ◽  
Lorenzo Lorenzo-Luaces ◽  
Irene Soeller ◽  
Susan Qing Li ◽  
Jun J. Mao ◽  
...  
Keyword(s):  
Prospective Study ◽  
Relapse Prevention ◽  
Mood Stabilizer ◽  
Double Blind ◽  
Parallel Group ◽  
Bipolar Ii

scholarly journals Efficacy and mood conversion rate during long-term fluoxetine v. lithium monotherapy in rapid- and non-rapid-cycling bipolar II disorder

2013 ◽  
Vol 202 (4) ◽  
pp. 301-306 ◽  
Author(s):  
Jay D. Amsterdam ◽  
Lola Luo ◽  
Justine Shults
Keyword(s):  
Relapse Prevention ◽  
Rapid Cycling ◽  
Double Blind ◽  
Bipolar Ii Disorder ◽  
Safety And Efficacy ◽  
Double Blind Placebo ◽  
Prevention Therapy ◽  
Bipolar Ii ◽  
Antidepressant Use

BackgroundControversy exists over antidepressant use in rapid-cycling bipolar disorder.AimsExploratory analysis of safety and efficacy of fluoxetine v. lithium monotherapy in individuals with rapid- v. non-rapid-cycling bipolar II disorder.MethodRandomised, double-blind, placebo-controlled comparison of fluoxetine v. lithium monotherapy in patients initially stabilised on fluoxetine monotherapy (trial registration NCT0O044616).ResultsThe proportion of participants with depressive relapse was similar between the rapid- and non-rapid-cycling groups (P=0.20). The odds of relapse were similar between groups (P=0.36). The hazard of relapse was similar between groups (hazard ratio 0.87, 95% CI 0.40-1.91). Change in mania rating scores was similar between groups (P=0.86). There was no difference between groups in the rate of syndromal (P-0.27) or subsyndromal (P=0.82) hypomania.ConclusionsDepressive relapse and treatment-emergent mood conversion episode rates were similar for lithium and fluoxetine monotherapy and placebo during long-term, relapse-prevention therapy of rapid- and non-rapid-cycling bipolar II disorder.

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