Oral ketamine reduces the experience of stress in people with chronic suicidality

2022 ◽  
Vol 300 ◽  
pp. 410-417
Author(s):  
Megan Dutton ◽  
Adem T. Can ◽  
Denise Beaudequin ◽  
Emma Jensen ◽  
Monique Jones ◽  
...  
Keyword(s):  
Oral Ketamine ◽  
Experience Of Stress ◽  
Chronic Suicidality

scholarly journals Low dose oral ketamine treatment in chronic suicidality: An open-label pilot study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Adem T. Can ◽  
Daniel F. Hermens ◽  
Megan Dutton ◽  
Cyrana C. Gallay ◽  
Emma Jensen ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Low Dose ◽  
Suicide Ideation ◽  
Well Being ◽  
Primary Outcome Measure ◽  
Open Label ◽  
Oral Ketamine ◽  
High Level ◽  
Chronic Suicidality

AbstractRecently, low-dose ketamine has been proposed as a rapid-acting treatment option for suicidality. The majority of studies to date have utilised intravenous (IV) ketamine, however, this route of administration has limitations. On the other hand, oral ketamine can be administered in a range of settings, which is important in treating suicidality, although studies as to safety and feasibility are lacking. n = 32 adults (aged 22–72 years; 53% female) with chronic suicidal thoughts participated in the Oral Ketamine Trial on Suicidality (OKTOS), an open-label trial of sub-anaesthetic doses of oral ketamine over 6 weeks. Participants commenced with 0.5 mg/kg of ketamine, which was titrated to a maximum 3.0 mg/kg. Follow-up assessments occurred at 4 weeks after the final dose. The primary outcome measure was the Beck Scale for Suicide Ideation (BSS) and secondary measures included scales for suicidality and depressive symptoms, and measures of functioning and well-being. Mean BSS scores significantly reduced from a high level of suicidal ideation at the pre-ketamine (week 0) timepoint to below the clinical threshold at the post-ketamine (week 6) timepoint. The proportion of participants that achieved clinical improvement within the first 6 weeks was 69%, whereas 50% achieved a significant improvement by the follow-up (week 10) timepoint. Six weeks of oral ketamine treatment in participants with chronic suicidality led to significant reduction in suicidal ideation. The response observed in this study is consistent with IV ketamine trials, suggesting that oral administration is a feasible and tolerable alternative treatment for chronic suicidality.

Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume

2021 ◽  
Vol 317 ◽  
pp. 111369
Author(s):  
Cyrana C. Gallay ◽  
Grace Forsyth ◽  
Adem T. Can ◽  
Megan Dutton ◽  
Daniel Jamieson ◽  
...  
Keyword(s):  
Grey Matter ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
Oral Ketamine ◽  
Chronic Suicidality

Self-determination and the experience of stress

2007 ◽  
Author(s):  
Netta Weinstein ◽  
Holley S. Hodgins
Keyword(s):  
Self Determination ◽  
Experience Of Stress

Subjective factors affecting gun shooting accuracy among employees of internal affairs agencies in process of learning

2020 ◽  
Vol 2020 (4) ◽  
pp. 198-206
Author(s):  
Anton Rozhkov ◽  
Anton Popov ◽  
Vitaliy Balahonskiy
Keyword(s):  
Subjective Experience ◽  
Statistical Significance ◽  
Self Regulation ◽  
Sensorimotor Coordination ◽  
Factors Affecting ◽  
Intelligent Behavior ◽  
Experience Of Stress ◽  
Firing Line ◽  
High Level ◽  
In Fire

The article is devoted to the study of subjective factors affecting shooting accuracy of law enforcement officers. The empirical study identified some subjective factors reducing gun shooting accuracy and effectiveness among law enforcers. These characteristics include sensorimotor coordination and subjective experience of stress during the shooting process. Scientific analysis made it possible to determine statistical significance of the influence of these factors on the accuracy of shooting. To increase the effectiveness of shooting among officers with a low index of sensorimotor coordination, the authors suggest using exercises aimed at cultivating sensorimotor coordination in fire training classes. While working with employees being under a high level of subjectively experienced stress, more attention should be paid to training techniques to overcome stress and form intelligent behavior in extreme situations. The authors also draw readers’ attention to factors increasing the effectiveness of shooting: officers’ ability to determine the subjective level of stress, their knowledge of emotional self-regulation techniques, knowledge of the sequence of their actions in the firing line.

Qualitative Research on the Recovery Experience of Stress in the Counselor’s Counseling Process

2017 ◽  
Vol 8 (2) ◽  
pp. 365-386
Author(s):  
Gyeong Suk Cho ◽  
Yun Gyeong Seo ◽  
Chun Hua Yu ◽  
Bo Bae Lee ◽  
Ye Jeong Kim
Keyword(s):  
Qualitative Research ◽  
Counseling Process ◽  
Experience Of Stress

Taking the strain: Social identity, social support, and the experience of stress

2005 ◽  
Vol 44 (3) ◽  
pp. 355-370 ◽  
Author(s):  
S. Alexander Haslam ◽  
Anne O'Brien ◽  
Jolanda Jetten ◽  
Karine Vormedal ◽  
Sally Penna
Keyword(s):  
Social Support ◽  
Social Identity ◽  
Experience Of Stress

Chronic Suicidality: A Commentary on Lewin

Psychiatry ◽  
1992 ◽  
Vol 55 (1) ◽  
pp. 22-23
Author(s):  
Michael A. Hoge
Keyword(s):  
Chronic Suicidality
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