P2-120: Amyloid deposition and cerebral glucose metabolism in mild cognitive impairment : A longitudinal 11 C-PIB and 18 F-FDG PET study

Background: Total score (TS) of semantic verbal fluency test (SVFT) is generally used to interpret results, but it is ambiguous as to specific neural functions it reflects. Different SVFT strategy scores reflecting qualitative aspects are proposed to identify specific cognitive functions to overcome limitations of using the TS. Objective: Functional neural correlates of the TS as well as the other strategy scores in subjects with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia using Fluorine-18-Fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: Correlations between various SVFT scores (i.e., TS, mean cluster size, switching (SW), hard switching, cluster switching (CSW)) and cerebral glucose metabolism were explored using voxelwise whole-brain approach. Subgroup analyses were also performed based on the diagnosis and investigated the effects of disease severity on the associations. Results: Significant positive correlation between TS and cerebral glucose metabolism was found in prefrontal, parietal, cingulate, temporal cortex, and subcortical regions. Significantly increased glucose metabolism associated with the SW were found in similar but smaller regions, mainly in the fronto-parieto-temporal regions. CSW was only correlated with the caudate. In the subgroup analysis conducted to assess different contribution of clinical severity, differential associations between the strategy scores and regional glucose metabolism were found. Conclusion: SW and CSW may reflect specific language and executive functions better than the TS. The SVFT is influenced by brain dysfunction due to the progression of AD, as demonstrated by the SW with larger involvement of temporal lobe for the AD, and CSW with significant association only for the MCI.

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Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment

Current Alzheimer Research ◽

10.2174/1567205016666190805155230 ◽

2019 ◽

Vol 16 (9) ◽

pp. 852-860 ◽

Cited By ~ 1

Author(s):

Atsuko Eguchi ◽

Noriyuki Kimura ◽

Yasuhiro Aso ◽

Kenichi Yabuuchi ◽

Masato Ishibashi ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Glucose Metabolism ◽

Statistical Parametric Mapping ◽

Japanese Version ◽

Amyloid Deposition ◽

Cerebral Glucose Metabolism ◽

Positron Emission ◽

The Relationship ◽

Moca Score

Background: The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. Objective: This prospective study examined the relationship between the Japanese version of the MoCA (MoCA-J) test and brain amyloid deposition or cerebral glucose metabolism among subjects with mild cognitive impairment. Methods: A total of 125 subjects with mild cognitive impairment underwent the MoCA-J test, and amyloid- and 18F-fluorodeoxyglucose- positron emission tomography. Linear correlation analysis and multiple linear regression analysis were conducted to investigate the relationship between the MoCA-J score and demographic characteristics, amyloid deposition, and cerebral glucose metabolism. Moreover, Statistical Parametric Mapping 8 was used for a voxel-wise regression analysis of the MoCA-J score and cerebral glucose metabolism. Results: The MoCA-J score significantly correlated with age, years of education, and the Mini-Mental State Examination score. After adjusting for age, sex, and education, the MoCA-J score significantly correlated negatively with amyloid retention (β= -0.174, p= 0.031) and positively with cerebral glucose metabolism (β= 0.183, p= 0.044). Statistical Parametric Mapping showed that Japanese version of MoCA score correlated with glucose metabolism in the bilateral frontal and parietal lobes, and the left precuneus. Conclusion: The total MoCA-J score correlated with amyloid deposition and frontal and parietal glucose metabolism in subjects with mild cognitive impairment. Our findings support the usefulness of the MoCA-J test for screening subjects at high risk for Alzheimer’s disease.

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Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Movement Disorders ◽

10.1002/mds.22444 ◽

2009 ◽

Vol 24 (6) ◽

pp. 854-862 ◽

Cited By ~ 73

Author(s):

Yoshiyuki Hosokai ◽

Yoshiyuki Nishio ◽

Kazumi Hirayama ◽

Atsushi Takeda ◽

Toshiyuki Ishioka ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Glucose Metabolism ◽

Cerebral Glucose Metabolism ◽

Regional Cerebral Glucose Metabolism

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IC-P-012: Subtypes of mild cognitive impairment differentiated based on limbic white matter integrity and cortical glucose metabolism: A pilot study using DTI and FDG-PET

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.027 ◽

2010 ◽

Vol 6 ◽

pp. S10-S10 ◽

Cited By ~ 1

Author(s):

Igor O. Korolev ◽

Lori A. Hoisington ◽

Kevin L. Berger ◽

Andrea C. Bozoki

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Pilot Study ◽

Glucose Metabolism ◽

Fdg Pet ◽

White Matter Integrity

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The Transition of Mild Cognitive Impairment Over Time: An AV45- and FDG-PET Study of Reversion and Conversion Phenomena

Current Alzheimer Research ◽

10.2174/1567205018666211124110710 ◽

2021 ◽

Vol 18 ◽

Author(s):

Amir Ashraf-Ganjouei ◽

Kamyar Moradi ◽

Shahriar Faghani ◽

AmirHussein Abdolalizadeh ◽

Mohammadreza Khomeijani-Farahani ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Glucose Metabolism ◽

Pet Imaging ◽

Fdg Pet ◽

Amyloid Β ◽

Positron Emission ◽

One Year ◽

T Tau ◽

Over Time

Background: Mild cognitive impairment (MCI) is a state between normal cognition and dementia. However, MCI diagnosis does not necessarily guarantee the progression to dementia. Since no previous study investigated brain positron emission tomography (PET) imaging of MCI-- to-normal reversion, we provided PET imaging of MCI-to-normal reversion using the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Methods: We applied comprehensive neuropsychological criteria (NP criteria), consisting of mem- ory, language, and attention/executive function domains, to include patients with a baseline diagno- sis of MCI (n=613). According to the criteria, the year 1 status of the patients was categorized into three groups (reversion: n=105, stable MCI: n=422, conversion: n=86). Demographic, neuropsycho- logical, genetic, CSF, and cognition biomarker variables were compared between the groups. Addi- tionally, after adjustment for confounding variables, the deposition pattern of amyloid-β and cere- bral glucose metabolism were compared between three groups via AV45- and FDG-PET modali- ties, respectively. Results: MCI reversion rate was 17.1% during one year of follow-up. The reversion group had the lowest frequency of APOE ε4+ subjects, the highest CSF level of amyloid-β, and the lowest CSF levels of t-tau and p-tau. Neuropsychological assessments were also suggestive of better cognitive performance in the reversion group. Patients with reversion to normal state had higher glucose metabolism in bilateral angular and left middle/inferior temporal gyri, when compared to those with stable MCI state. Meanwhile, lower amyloid-β deposition at baseline was observed in the fron- tal and parietal regions of the reverted subjects. On the other hand, the conversion group showed lower cerebral glucose metabolism in bilateral angular and bilateral middle/inferior temporal gyri compared to the stable MCI group, whereas the amyloid-β accumulation was similar between the groups. Conclusions: This longitudinal study provides novel insight regarding the application of PET imag- ing in predicting MCI transition over time.

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