P1-412: Isoprenoids phenocopy familial Alzheimer&#39;s disease mutations and regulate gamma-secretase

Disease Mutations ◽

O2-04-06: The role of presenilin 1 familial Alzheimer's disease mutations for gamma-secretase activity and changed structural conformation

Alzheimer s & Dementia ◽

10.1016/j.jalz.2012.05.645 ◽

2012 ◽

Vol 8 (4S_Part_7) ◽

pp. P242-P242

Author(s):

Patricia Lara Vasquez ◽

Johanna Wanngren ◽

Silvia Maioli ◽

Lars Tjernberg ◽

Bengt Winblad ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Presenilin 1 ◽

Gamma Secretase ◽

Structural Conformation ◽

Disease Mutations ◽

Secretase Activity ◽

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of >45 residues

Journal of Biological Chemistry ◽

10.1016/j.jbc.2021.100281 ◽

2021 ◽

pp. 100281

Author(s):

Sujan Devkota ◽

Todd D. Williams ◽

Michael S. Wolfe

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Β ◽

Amyloid Protein ◽

Protein Precursor ◽

Amyloid Protein Precursor ◽

Disease Mutations ◽

β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations

Molecular Brain Research ◽

10.1016/s0169-328x(01)00294-7 ◽

2001 ◽

Vol 97 (1) ◽

pp. 103-113 ◽

Cited By ~ 44

Author(s):

Donna L McPhie ◽

Todd Golde ◽

Christopher B Eckman ◽

Debra Yager ◽

Justin B Brant ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Precursor Protein ◽

Neuronal Apoptosis ◽

Precursor Protein ◽

Disease Mutations ◽

P2-378: Clinical and quantitative fluorodeoxyglucose positron emission tomography in presymptomatic and symptomatic persons inheriting familial Alzheimer's disease mutations

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1430 ◽

2010 ◽

Vol 6 ◽

pp. S427-S427

Author(s):

John M. Ringman ◽

Soo K. Lee ◽

Jorge Barrio ◽

Giovanni Coppola ◽

Gary Small ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Positron Emission Tomography ◽

Emission Tomography ◽

Fluorodeoxyglucose Positron Emission Tomography ◽

Fluorodeoxyglucose Positron Emission

Positron Emission ◽

Disease Mutations ◽

Familial Alzheimer's Disease ◽

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

American Journal Of Pathology ◽

10.2353/ajpath.2010.090482 ◽

2010 ◽

Vol 176 (1) ◽

pp. 353-368 ◽

Cited By ~ 49

Author(s):

Miguel A. Gama Sosa ◽

Rita De Gasperi ◽

Anne B. Rocher ◽

Athena Ching-Jung Wang ◽

William G.M. Janssen ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transgenic Mice ◽

Vascular Pathology ◽

Presenilin 1 ◽

Age Related ◽

Disease Mutations ◽

Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence

Journal of Biological Chemistry ◽

10.1074/jbc.271.38.23380 ◽

1996 ◽

Vol 271 (38) ◽

pp. 23380-23388 ◽

Cited By ~ 100

Author(s):

Andrew G. Reaume ◽

David S. Howland ◽

Stephen P. Trusko ◽

Mary J. Savage ◽

Diane M. Lang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Precursor Protein ◽

Precursor Protein ◽

Amyloidogenic Processing ◽

Disease Mutations ◽

Β Amyloid ◽

Effects of Risk Genes on BOLD Activation in Presymptomatic Carriers of Familial Alzheimer's Disease Mutations during a Novelty Encoding Task

Cerebral Cortex ◽

10.1093/cercor/bhq158 ◽

2010 ◽

Vol 21 (4) ◽

pp. 877-883 ◽

Cited By ~ 13

Author(s):

J. M. Ringman ◽

L. D. Medina ◽

M. Braskie ◽

Y. Rodriguez-Agudelo ◽

D. H. Geschwind ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Risk Genes ◽

Disease Mutations ◽

Effects of Familial Alzheimer’s Disease Mutations on the Folding Nucleation of the Amyloid β-Protein

Journal of Molecular Biology ◽

10.1016/j.jmb.2008.05.069 ◽

2008 ◽

Vol 381 (1) ◽

pp. 221-228 ◽

Cited By ~ 74

Author(s):

Mary Griffin Krone ◽

Andrij Baumketner ◽

Summer L. Bernstein ◽

Thomas Wyttenbach ◽

Noel D. Lazo ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Β ◽

Amyloid Β Protein ◽

Disease Mutations ◽

Β Protein ◽

Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations

Brain ◽

10.1093/brain/awm102 ◽

2007 ◽

Vol 130 (7) ◽

pp. 1767-1776 ◽

Cited By ~ 147

Author(s):

J. M. Ringman ◽

J. O'Neill ◽

D. Geschwind ◽

L. Medina ◽

L. G. Apostolova ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Diffusion Tensor Imaging ◽

Diffusion Tensor ◽

Disease Mutations ◽

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer’s Disease

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01620 ◽

2017 ◽

Vol 60 (6) ◽

pp. 2383-2400 ◽

Cited By ~ 8

Author(s):

Matthew G. Bursavich ◽

Bryce A. Harrison ◽

Raksha Acharya ◽

Donald E. Costa ◽

Emily A. Freeman ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gamma Secretase ◽

Design Synthesis ◽