scholarly journals Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease

2011 ◽  
Vol 7 (4) ◽  
pp. 445-455 ◽  
Author(s):  
Alex E. Roher ◽  
Zsolt Garami ◽  
Suzanne L. Tyas ◽  
Chera L. Maarouf ◽  
Tyler A. Kokjohn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Flow Velocity ◽  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Blood Flow Velocity ◽  
Pulsatility Index ◽  
Transcranial Doppler Ultrasound ◽  
Systemic Indicators

Cerebrovascular Reactivity in Migraineurs as Measured by Transcranial Doppler

Cephalalgia ◽  
1990 ◽  
Vol 10 (2) ◽  
pp. 95-99 ◽  
Author(s):  
T Darrell Thomas ◽  
Gary J Harpold ◽  
B Todd Troost
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Flow Velocity ◽  
Doppler Ultrasound ◽  
Cerebral Artery ◽  
Transcranial Doppler ◽  
Blood Flow Velocity ◽  
Transcranial Doppler Ultrasound ◽  
Cerebrovascular Reactivity ◽  
Artery Blood Flow

Transcranial Doppler ultrasound is a relatively new diagnostic modality which allows the non-invasive assessment of intracranial circulation. A total of 10 migraine patients were studied and compared to healthy controls without headaches. Migraineurs during the headache-free interval demonstrated excessive cerebrovascular reactivity to CO2, evidenced by an increase in middle cerebral artery blood flow velocity of 47% ± 15% compared to 28% ± 14% in controls ( p = 0.026). Differences between the two study groups revealed no significant decrease in middle cerebral artery blood flow velocity with hypocapnia. However, the differences between middle cerebral artery blood flow velocity during hyperventilation and CO2 inhalation were significantly different ( p = 0.004) comparing migraineurs and controls. Instability of the baseline blood flow velocities was also noted in migraineurs during the interictal period. Characteristics which may allow differentiation of migraineurs from other headache populations could possibly be obtained from transcranial Doppler ultrasound flow studies.

scholarly journals Transcranial Doppler ultrasound is a diagnostic and predicting tool for movement disorders in children after hypoxic ischemic encephalopathy

2021 ◽  
Vol 4 (3) ◽  
pp. 254-259
Author(s):  
K.A. Pugolovkin ◽  
◽  
E.A. Efimova ◽  
E.A. Dombrovskaya ◽  
I.Yu. Platonova ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Doppler Ultrasound ◽  
Movement Disorders ◽  
Transcranial Doppler ◽  
Motor Skill ◽  
Blood Flow Velocity ◽  
Transcranial Doppler Ultrasound ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

Aim: to assess brain circulation in the regions supplied by the basilar artery (BA) in children with movement disorders and motor skill delay in the late rehabilitative period after hypoxic ischemic encephalopathy and its importance for the objectivity of clinical data and evaluation of rehabilitative effect. Patients and Methods: 28 children (mean age one year seven months) with movement disorders and motor skill delay (after hypoxic ischemic CNS lesion in the perinatal period) without lower extremity paraparesis or Willis circle abnormalities (by Doppler ultrasound) were examined. Doppler ultrasound was performed using the suboccipital approach at 3–8 months with 3–4-month intervals. The parameters of blood flow in BA, i.e., resistivity index (RI) and mean blood flow velocity (Vm), were measured. Retrospectively, children were divided into three groups based on motor skill delay severity (mild, moderate, or severe) and time for standing unaided to walking. Mean values in the groups and relative deviations (increase/decrease) from reference values in a given age group were compared. Results: motor skill delay severity and predicting time for standing unaided to walking correlated with RI and Vm. RI was a diagnostically valuable parameter whose reference values differed from motor skill delay severity. Isolated increase in Vm and normal RI were reported in children with motor skill delay 1–3 months before standing unaided to walking. This type of blood circulation is a transitional one during clinical improvement in some children. Conclusions: a set of instrumental data allow for describing motor skill delay severity depending on RI deviations from normal values in the regions supplied by BA. The sequence of brain circulation parameter changes is in line with the clinical course, e.g., RI normalization and further gradual recovery of blood flow velocity. KEYWORDS: movement disorders, motor skill delay, Transcranial Doppler ultrasound, basilar artery, resistivity index RI, mean blood flow velocity Vm. FOR CITATION: Pugolovkin K.A., Efimova E.A., Dombrovskaya E.A. et al. Transcranial Doppler ultrasound is a diagnostic and predicting tool for movement disorders in children after hypoxic ischemic encephalopathy. Russian Journal of Woman and Child Health. 2021;4(3):254–259 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-254-259.

Transcranial Doppler Pulsatility Index: Not an Accurate Method to Assess Intracranial Pressure

Neurosurgery ◽  
2010 ◽  
Vol 66 (6) ◽  
pp. 1050-1057 ◽  
Author(s):  
Anders Behrens ◽  
Niklas Lenfeldt ◽  
Khalid Ambarki ◽  
Jan Malm ◽  
Anders Eklund ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intracranial Pressure ◽  
Flow Velocity ◽  
Transcranial Doppler ◽  
Blood Flow Velocity ◽  
Pulsatility Index ◽  
Transcranial Doppler Sonography ◽  
Accurate Method ◽  
Mathematical Simulations

Abstract BACKGROUND Transcranial Doppler sonography (TCD) assessment of intracranial blood flow velocity has been suggested to accurately determine intracranial pressure (ICP). OBJECTIVE We attempted to validate this method in patients with communicating cerebrospinal fluid systems using predetermined pressure levels. METHODS Ten patients underwent a lumbar infusion test, applying 4 to 5 preset ICP levels. On each level, the pulsatility index (PI) in the middle cerebral artery was determined by measuring the blood flow velocity using TCD. ICP was simultaneously measured with an intraparenchymal sensor. ICP and PI were compared using correlation analysis. For further understanding of the ICP-PI relationship, a mathematical model of the intracranial dynamics was simulated using a computer. RESULTS The ICP-PI regression equation was based on data from 8 patients. For 2 patients, no audible Doppler signal was obtained. The equation was ICP = 23*PI + 14 (R2 = 0.22, P < .01, N = 35). The 95% confidence interval for a mean ICP of 20 mm Hg was −3.8 to 43.8 mm Hg. Individually, the regression coefficients varied from 42 to 90 and the offsets from −32 to +3. The mathematical simulations suggest that variations in vessel compliance, autoregulation, and arterial pressure have a serious effect on the ICP-PI relationship. CONCLUSIONS The in vivo results show that PI is not a reliable predictor of ICP. Mathematical simulations indicate that this is caused by variations in physiological parameters.

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