IC-P-098: ALTERNATIVE CEREBRAL GLUCOSE UPTAKE METRICS DETECT EARLY METABOLIC CHANGES IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P55-P55
Author(s):  
Drew R. DeBay ◽  
Ian R. Macdonald ◽  
G. Andrew Reid ◽  
Tim P. O'Leary ◽  
Courtney T. Jollymore ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Glucose Uptake ◽  
Metabolic Changes ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

P1-296: ALTERNATIVE CEREBRAL GLUCOSE UPTAKE METRICS DETECT EARLY METABOLIC CHANGES IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P419-P419
Author(s):  
Drew R. DeBay ◽  
Ian R. Macdonald ◽  
G. Andrew Reid ◽  
Tim P. O'Leary ◽  
Courtney T. Jollymore ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Glucose Uptake ◽  
Metabolic Changes ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

scholarly journals Correction: Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194586 ◽  
Author(s):  
Manuel van Gijsel-Bonnello ◽  
Kévin Baranger ◽  
Philippe Benech ◽  
Santiago Rivera ◽  
Michel Khrestchatisky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Metabolic Changes ◽  
Model Of Alzheimer’S Disease ◽  
Cultured Astrocytes ◽  
5Xfad Mouse

scholarly journals Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175369 ◽  
Author(s):  
Manuel van Gijsel-Bonnello ◽  
Kévin Baranger ◽  
Philippe Benech ◽  
Santiago Rivera ◽  
Michel Khrestchatisky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Metabolic Changes ◽  
Model Of Alzheimer’S Disease ◽  
Cultured Astrocytes ◽  
5Xfad Mouse

scholarly journals Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease

2020 ◽  
Vol 14 ◽  
Author(s):  
Jeremiah K. H. Lim ◽  
Qiao-Xin Li ◽  
Zheng He ◽  
Algis J. Vingrys ◽  
Holly R. Chinnery ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Structural Changes ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

Exercise‐Induced Alterations in TrkB expression in the 5XFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 17 (S2) ◽  
Author(s):  
Christopher Moylan ◽  
Thanh Vinh Cao ◽  
Quy‐Susan Huynh ◽  
Anishchal Pratap ◽  
R. M. Damian Holsinger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse ◽  
Exercise Induced

Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Fanglei Han ◽  
Jia Zhao ◽  
Guoqing Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Volatile Anesthetics ◽  
Model Of Alzheimer’S Disease ◽  
Short Term Exposure ◽  
5Xfad Mouse ◽  
Anesthetic Exposure ◽  
5Xfad Mice

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease which shows a set of symptoms involving cognitive changes and psychological changes. Given that AD is the most common form of dementia in aging population and the increasing demand for anesthesia/surgery with aging, there has been significant interest in the exact impact of volatile anesthetics on cognitive function and pathological alterations in AD population. Objective: This study aimed to investigate behavioral changes and neuropathology in the 5xFAD mouse model of Alzheimer’s disease with short-term exposure or long-term exposure to desflurane, sevoflurane, or isoflurane. Methods: In this study, we exposed 5xFAD mouse model of AD to isoflurane, sevoflurane, or desflurane in two different time periods (30 min and 6 h), and the memory related behaviors as well as the pathological changes in 5xFAD mice were evaluated 7 days after the anesthetic exposure. Results: We found that short-term exposure to volatile anesthetics did not affect hippocampus dependent memory and the amyloid-β (Aβ) deposition in the brain. However, long-term exposure to sevoflurane or isoflurane significantly increased the Aβ deposition in CA1 and CA3 regions of hippocampus, as well as the glial cell activation in amygdala. Besides, the PSD-95 expression was decreased in 5xFAD mice with exposure to sevoflurane or isoflurane and the caspase-3 activation was enhanced in isoflurane, sevoflurane, and desflurane groups. Conclusion: Our results demonstrate the time-dependent effects of common volatile anesthetics and implicate that desflurane has the potential benefits to prolonged anesthetic exposure in AD patients.

Sign in / Sign up

Export Citation Format

Share Document