scholarly journals A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42

2015 ◽  
Vol 11 (12) ◽  
pp. 1452-1460 ◽  
Author(s):  
Kristel Sleegers ◽  
Karolien Bettens ◽  
Arne De Roeck ◽  
Caroline Van Cauwenberghe ◽  
Elise Cuyvers ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Single Nucleotide Polymorphism ◽  
Cerebrospinal Fluid ◽  
Family History ◽  
Risk Score ◽  
Disease Risk ◽  
Onset Age ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Disease Risk Score

scholarly journals Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Serena Bucossi ◽  
Stefania Mariani ◽  
Mariacarla Ventriglia ◽  
Renato Polimanti ◽  
Massimo Gennarelli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Nucleotide Polymorphism ◽  
Logistic Regression ◽  
Atp7b Gene ◽  
Regression Analyses ◽  
Susceptibility Loci ◽  
Nucleotide Polymorphism ◽  
Sporadic Alzheimer’S Disease ◽  
Single Nucleotide

Nonceruloplasmin-bound copper (“free”) is reported to be elevated in Alzheimer's disease (AD). In Wilson's disease (WD) Cu-ATPase 7B protein tightly controls free copper body levels. To explore whether the ATP7B gene harbours susceptibility loci for AD, we screened 180 AD chromosomes for sequence changes in exons 2, 5, 8, 10, 14, and 16, where most of the Mediterranean WD-causing mutations lie. No WD mutation, but sequence changes corresponding to c.1216 T>G Single-Nucleotide Polymorphism (SNP) and c.2495 A>G SNP were found. Thereafter, we genotyped 190 AD patients and 164 controls for these SNPs frequencies estimation. Logistic regression analyses revealed either a trend for the c.1216 SNP (P=.074) or a higher frequency for c.2495 SNP of the GG genotype in patients, increasing the probability of AD by 74% (P=.028). Presence of the GG genotype in ATP7B c.2495 could account for copper dysfunction in AD which has been shown to raise the probability of the disease.

Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

2005 ◽  
Vol 5 (4) ◽  
pp. 275-279 ◽  
Author(s):  
Abdulaziz Ali A. Al-Khedhai ◽  
Misbahul Arfin . ◽  
Bassam A. Alahmadi . ◽  
Mohamed A. Al-Jumah .
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Nucleotide Polymorphism ◽  
Late Onset ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

[P1-423]: THE DEVELOPMENT OF AN ALZHEIMER's DISEASE RISK SCORE BASED ON THE CORTICAL THICKNESS ANALYSES

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P440-P441
Author(s):  
Jin San Lee ◽  
Jeong-Hyeon Shin ◽  
Hanna Cho ◽  
Young Kyoung Jang ◽  
Hee Jin Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cortical Thickness ◽  
Risk Score ◽  
Disease Risk ◽  
Disease Risk Score

Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease

2002 ◽  
Vol 333 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Victor Mubumbila ◽  
Anne Sutter ◽  
Ursula Ptok ◽  
Reinhard Heun ◽  
Christiane Quirin-Stricker
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Nucleotide Polymorphism ◽  
Choline Acetyltransferase ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Single-Nucleotide Polymorphism–Based Genetic Risk Score and Patient Age at Prostate Cancer Diagnosis

2019 ◽  
Vol 2 (12) ◽  
pp. e1918145
Author(s):  
Rong Na ◽  
Craig Labbate ◽  
Hongjie Yu ◽  
Zhuqing Shi ◽  
Richard J. Fantus ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Risk Score ◽  
Cancer Diagnosis ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Nucleotide Polymorphism ◽  
Patient Age ◽  
Single Nucleotide ◽  
Prostate Cancer Diagnosis

P1-275: A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S177-S177
Author(s):  
Lesley Jones ◽  
Denise Harold ◽  
Stuart MacGregor ◽  
Cathryn E. Patterson ◽  
Paul Hollingworth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Nucleotide Polymorphism ◽  
Acetylcholinesterase Inhibitors ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Twelve–Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke

Stroke ◽  
2014 ◽  
Vol 45 (10) ◽  
pp. 2856-2862 ◽  
Author(s):  
Hayato Tada ◽  
Dov Shiffman ◽  
J. Gustav Smith ◽  
Marketa Sjögren ◽  
Steven A. Lubitz ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Single Nucleotide Polymorphism ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Increased Risk
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