P1-222: Auditory verbal learning test is superior to rey-osterrieth complex figure memory for predicting progression from mild cognitive impairment to Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_9) ◽  
pp. P436-P437 ◽  
Author(s):  
Qianhua Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Verbal Learning ◽  
Auditory Verbal Learning Test ◽  
Complex Figure ◽  
Auditory Verbal Learning ◽  
Learning Test

scholarly journals Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Leonardino A Digma ◽  
John R Madsen ◽  
Robert A Rissman ◽  
Diane M Jacobs ◽  
James B Brewer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Verbal Memory ◽  
Memory Performance ◽  
Verbal Learning ◽  
Amyloid Β ◽  
Auditory Verbal Learning Test ◽  
Logical Memory ◽  
Auditory Verbal Learning ◽  
Learning Test

Abstract In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Using data from 121 amyloid-β-positive Alzheimer’s Disease Neuroimaging Initiative participants, we fit a linear model with Rey Auditory Verbal Learning Test score as the response variable and tau-PET standard uptake value ratio as the predictor and took the residuals as an estimate of verbal memory reserve for each subject. Women demonstrated higher reserve (i.e. residuals), whether the Learning (t = 2.78, P = 0.006) or Delay (t = 2.14, P = 0.03) score from the Rey Auditory Verbal Learning Test was used as a measure of verbal memory ability. To validate these findings, we examined 662 National Alzheimer’s Coordinating Center participants with a C2/C3 score (Consortium to Establish a Registry for Alzheimer’s Disease) at autopsy. We stratified our National Alzheimer’s Coordinating Center sample into Braak 1/2, Braak 3/4 and Braak 5/6 subgroups. Within each subgroup, we compared Logical Memory scores between men and women. Men had worse verbal memory scores within the Braak 1/2 (Logical Memory Immediate: β = −5.960 ± 1.517, P < 0.001, Logical Memory Delay: β = −5.703 ± 1.677, P = 0.002) and Braak 3/4 (Logical Memory Immediate: β = −2.900 ± 0.938, P = 0.002, Logical Memory Delay: β = −2.672 ± 0.955, P = 0.006) subgroups. There were no sex differences in Logical Memory performance within the Braak 5/6 subgroup (Logical Memory Immediate: β = −0.314 ± 0.328, P = 0.34, Logical Memory Delay: β = −0.195 ± 0.287, P = 0.50). Taken together, our results point to a sex-related verbal memory reserve.

Sign in / Sign up

Export Citation Format

Share Document