Hopkins Verbal Learning Test Discriminates Mild Cognitive Impairment From Alzheimer's Disease

Abstract Reliable biomarkers of memory decline are critical for the early detection of Alzheimer’s disease. Previous work has found three EEG measures, namely the event-related brain potential P600, suppression of oscillatory activity in the alpha frequency range (∼10 Hz) and cross-frequency coupling between low theta/high delta and alpha/beta activity, each of which correlates strongly with verbal learning and memory abilities in healthy elderly and patients with mild cognitive impairment or prodromal Alzheimer’s disease. In the present study, we address the question of whether event-related or oscillatory measures, or a combination thereof, best predict the decline of verbal memory in mild cognitive impairment and Alzheimer’s disease. Single-trial correlation analyses show that despite a similarity in their time courses and sensitivities to word repetition, the P600 and the alpha suppression components are minimally correlated with each other on a trial-by-trial basis (generally |rs| < 0.10). This suggests that they are unlikely to stem from the same neural mechanism. Furthermore, event-related brain potentials constructed from bandpass filtered (delta, theta, alpha, beta or gamma bands) single-trial data indicate that only delta band activity (1–4 Hz) is strongly correlated (r = 0.94, P < 0.001) with the canonical P600 repetition effect; event-related potentials in higher frequency bands are not. Importantly, stepwise multiple regression analyses reveal that the three event-related brain potential/oscillatory measures are complementary in predicting California Verbal Learning Test scores (overall R2’s in 0.45–0.63 range). The present study highlights the importance of combining EEG event-related potential and oscillatory measures to better characterize the multiple mechanisms of memory failure in individuals with mild cognitive impairment or prodromal Alzheimer’s disease.

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Lexical semantic memory in amnestic mild cognitive impairment and mild Alzheimer's disease

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2007000400014 ◽

2007 ◽

Vol 65 (3a) ◽

pp. 619-622 ◽

Cited By ~ 13

Author(s):

Marcio L.F. Balthazar ◽

José E. Martinelli ◽

Fernando Cendes ◽

Benito P. Damasceno

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Semantic Memory ◽

Statistical Significance ◽

Verbal Learning ◽

Amnestic Mild Cognitive Impairment ◽

Memory Tests ◽

Lexical Semantic

OBJECTIVE: To study lexical semantic memory in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer's disease (AD) and normal controls. METHOD: Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, and that of aMCI, on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent semantic memory tests (Boston Naming-BNT, CAMCOG Similarities item), Rey Auditory Verbal Learning Test (RAVLT), Mini-Mental Status Examination (MMSE), neuropsychological tests (counterproofs), and Cornell Scale for Depression in Dementia. Data analysis used Mann-Whitney test for intergroup comparisons and Pearson's coefficient for correlations between memory tests and counterproofs (statistical significance level was p<0.05). RESULTS: aMCI patients were similar to controls on BNT and Similarities, but worse on MMSE and RAVLT. Mild AD patients scored significantly worse than aMCI and controls on all tests. CONCLUSION: aMCI impairs episodic memory but tends to spare lexical semantic system, which can be affected in the early phase of AD.

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P1-216: Comparison between the story recall test and the words list learning test in patients with mild cognitive impairment and early-stage Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2009.04.223 ◽

2009 ◽

Vol 5 (4S_Part_8) ◽

pp. P240-P240

Author(s):

Hyun J. Kim ◽

Min J. Baek ◽

YoungHee Chang ◽

Hee J. Kang ◽

SangYun Kim

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Recall Test ◽

Early Stage ◽

Story Recall ◽

List Learning ◽

Learning Test

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Comparison of the Hopkins Verbal Learning Test-Revised to the California Verbal Learning Test in Alzheimer's Disease

Applied Neuropsychology ◽

10.1207/s15324826an0803_8 ◽

2001 ◽

Vol 8 (3) ◽

pp. 180-184 ◽

Cited By ~ 45

Author(s):

Laura H. Lacritz ◽

C. Munro Cullum ◽

Myron F. Weiner ◽

Roger N. Rosenberg

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Verbal Learning ◽

California Verbal Learning Test ◽

Hopkins Verbal Learning Test ◽

Learning Test

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Verbal learning in Alzheimer's disease and mild cognitive impairment: fine-grained acquisition and short-delay consolidation performance and neural correlates

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2012.04.004 ◽

2013 ◽

Vol 34 (2) ◽

pp. 361-373 ◽

Cited By ~ 13

Author(s):

Sarah Genon ◽

Fabienne Collette ◽

Chris J.A. Moulin ◽

Françoise Lekeu ◽

Mohamed Ali Bahri ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Verbal Learning ◽

Neural Correlates ◽

Short Delay ◽

Fine Grained

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Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease

Psychological Medicine ◽

10.1017/s0033291703008031 ◽

2003 ◽

Vol 33 (6) ◽

pp. 1039-1050 ◽

Cited By ~ 144

Author(s):

C. A. DE JAGER ◽

E. HOGERVORST ◽

M. COMBRINCK ◽

M. M. BUDGE

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Executive Function ◽

Mild Cognitive Impairment ◽

Episodic Memory ◽

Sensitivity And Specificity ◽

Processing Speed ◽

Neuropsychological Tests ◽

Verbal Learning

Background. Early diagnosis of dementia is important for those who might benefit from treatment. We designed a brief comprehensive neuropsychological test battery to help differentiate control subjects from patients with mild cognitive impairment (MCI) and dementia.Method. The battery included tests of memory, attention, executive function, speed, perception and visuospatial skills. It was administered to subjects from the OPTIMA cohort: 51 controls, 29 with MCI, 60 with ‘possible’ or ‘probable’ Alzheimer's disease (AD) (NINCDS/ADRDA) and 12 with cerebrovascular disease (CVD). Mann–Whitney U tests were used to compare performance of controls with other diagnostic groups. The sensitivity and specificity of the tests were determined using Receiver Operating Characteristic curve analyses. The effects of age, gender and years of education on test performance were determined with Spearman's rank correlations.Results. The AD group performed worse than controls on all tests except an attention task. The Hopkins Verbal Learning Test and The Placing Test for episodic memory showed significant discriminative capacity between controls and other groups. Attention and processing speed tests discriminated CVD from controls. Category fluency, episodic memory tests and the CLOX test for executive function distinguished MCI from AD. Spearman's correlations showed negative associations between age and processing speed. Years of education affected performance on all tests, except The Placing Test.Conclusions. Certain neuropsychological tests have been shown to be sensitive and specific in the differential diagnosis of various types of dementia and may prove to be useful for detection of MCI.

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