[IC-P-114]: EXERCISE TRAINING AND CEREBRAL BLOOD FLOW IN PRECLINICAL ALZHEIMER's DISEASE: RESULTS FROM THE AEROBIC EXERCISE AND COGNITIVE HEALTH (REACH) STUDY

2017 ◽  
Vol 13 (7S_Part_2) ◽  
pp. P89-P90 ◽  
Author(s):  
Ryan J. Dougherty ◽  
Elizabeth A. Boots ◽  
Howard A. Rowley ◽  
Bruce P. Hermann ◽  
Mark A. Sager ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Preclinical Alzheimer’S Disease ◽  
Cognitive Health

[P2-571]: EXERCISE TRAINING AND CEREBRAL BLOOD FLOW IN PRECLINICAL ALZHEIMER's DISEASE: RESULTS FROM THE AEROBIC EXERCISE AND COGNITIVE HEALTH (REACH) STUDY

2017 ◽  
Vol 13 (7S_Part_17) ◽  
pp. P865-P865
Author(s):  
Ryan J. Dougherty ◽  
Elizabeth A. Boots ◽  
Howard A. Rowley ◽  
Bruce P. Hermann ◽  
Mark A. Sager ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Preclinical Alzheimer’S Disease ◽  
Cognitive Health

P4-266: Decreases in cerebral blood flow are associated with Aβ status in preclinical Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_19) ◽  
pp. P886-P886
Author(s):  
Amir Fazlollahi ◽  
Fernando Calamante ◽  
Xiaoyun Liang ◽  
Norm M. Good ◽  
Ashley Bush ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Preclinical Alzheimer’S Disease

scholarly journals The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

2016 ◽  
Vol 36 (2) ◽  
pp. 167-179 ◽  
Author(s):  
Chelsea C. Hays ◽  
Zvinka Z. Zlatar ◽  
Christina E. Wierenga
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Preclinical Alzheimer’S Disease

P1-023: Cardiorespiratory capacity correlates with cerebral blood flow, white matter hyperintensities, and cognition in preclinical Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P345-P345
Author(s):  
Elizabeth A. Boots ◽  
Stephanie A. Schultz ◽  
Jennifer M. Oh ◽  
Ryan J. Dougherty ◽  
Dorothy Farrar Edwards ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Preclinical Alzheimer’S Disease

P2-637: THE EFFECT OF AEROBIC EXERCISE TRAINING ON SERUM BDNF IN PRECLINICAL ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_18) ◽  
pp. P986-P986 ◽  
Author(s):  
Ryan J. Dougherty ◽  
Hyo Youl Moon ◽  
Elizabeth A. Boots ◽  
Andreas Becke ◽  
Emrah Düzel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Preclinical Alzheimer’S Disease ◽  
Serum Bdnf

IC-03-01: Cardiorespiratory capacity correlates with cerebral blood flow, white matter hyperintensities, and cognition in preclinical Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_1) ◽  
pp. P8-P8
Author(s):  
Elizabeth A. Boots ◽  
Stephanie A. Schultz ◽  
Jennifer M. Oh ◽  
Ryan J. Dougherty ◽  
Dorothy Farrar Edwards ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Preclinical Alzheimer’S Disease

Hypertension Impairs Cerebral Blood Flow in a Mouse Model for Alzheimer’s Disease

2015 ◽  
Vol 12 (10) ◽  
pp. 914-922 ◽  
Author(s):  
Maximilian Wiesmann ◽  
Carmen Capone ◽  
Valerio Zerbi ◽  
Laura Mellendijk ◽  
Arend Heerschap ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mouse Model

scholarly journals Autoregulation of Cerebral Blood Flow to Changes in Arterial Pressure in Mild Alzheimer's Disease

2010 ◽  
Vol 30 (11) ◽  
pp. 1883-1889 ◽  
Author(s):  
Allyson R Zazulia ◽  
Tom O Videen ◽  
John C Morris ◽  
William J Powers
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Pressure ◽  
The Elderly ◽  
Local Defect ◽  
Clinical Dementia Rating ◽  
Positron Emission ◽  
Before And After

Studies in transgenic mice overexpressing amyloid precursor protein (APP) demonstrate impaired autoregulation of cerebral blood flow (CBF) to changes in arterial pressure and suggest that cerebrovascular dysfunction may be critically important in the development of pathological Alzheimer's disease (AD). Given the relevance of such a finding for guiding hypertension treatment in the elderly, we assessed autoregulation in individuals with AD. Twenty persons aged 75±6 years with very mild or mild symptomatic AD (Clinical Dementia Rating 0.5 or 1.0) underwent 15O-positron emission tomography (PET) CBF measurements before and after mean arterial pressure (MAP) was lowered from 107±13 to 92±9 mm Hg with intravenous nicardipine; 11C-PIB-PET imaging and magnetic resonance imaging (MRI) were also obtained. There were no significant differences in mean CBF before and after MAP reduction in the bilateral hemispheres (−0.9±5.2 mL per 100 g per minute, P=0.4, 95% confidence interval (CI)=−3.4 to 1.5), cortical borderzones (−1.9±5.0 mL per 100 g per minute, P=0.10, 95% CI=−4.3 to 0.4), regions of T2W-MRI-defined leukoaraiosis (−0.3±4.4 mL per 100 g per minute, P=0.85, 95% CI=−3.3 to 3.9), or regions of peak 11C-PIB uptake (−2.5±7.7 mL per 100 g per minute, P=0.30, 95% CI=−7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD.

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