P2-637: THE EFFECT OF AEROBIC EXERCISE TRAINING ON SERUM BDNF IN PRECLINICAL ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_18) ◽  
pp. P986-P986 ◽  
Author(s):  
Ryan J. Dougherty ◽  
Hyo Youl Moon ◽  
Elizabeth A. Boots ◽  
Andreas Becke ◽  
Emrah Düzel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Preclinical Alzheimer’S Disease ◽  
Serum Bdnf

[IC-P-114]: EXERCISE TRAINING AND CEREBRAL BLOOD FLOW IN PRECLINICAL ALZHEIMER's DISEASE: RESULTS FROM THE AEROBIC EXERCISE AND COGNITIVE HEALTH (REACH) STUDY

2017 ◽  
Vol 13 (7S_Part_2) ◽  
pp. P89-P90 ◽  
Author(s):  
Ryan J. Dougherty ◽  
Elizabeth A. Boots ◽  
Howard A. Rowley ◽  
Bruce P. Hermann ◽  
Mark A. Sager ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Preclinical Alzheimer’S Disease ◽  
Cognitive Health

[P2-571]: EXERCISE TRAINING AND CEREBRAL BLOOD FLOW IN PRECLINICAL ALZHEIMER's DISEASE: RESULTS FROM THE AEROBIC EXERCISE AND COGNITIVE HEALTH (REACH) STUDY

2017 ◽  
Vol 13 (7S_Part_17) ◽  
pp. P865-P865
Author(s):  
Ryan J. Dougherty ◽  
Elizabeth A. Boots ◽  
Howard A. Rowley ◽  
Bruce P. Hermann ◽  
Mark A. Sager ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Preclinical Alzheimer’S Disease ◽  
Cognitive Health

scholarly journals Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Julian M. Gaitán ◽  
Hyo Youl Moon ◽  
Matthew Stremlau ◽  
Dena B. Dubal ◽  
Dane B. Cook ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Brain Function ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Cognitive Changes ◽  
Middle Aged Adults

Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. To begin to address this issue, we utilized blood samples of 23 asymptomatic late middle-aged adults, with familial and genetic risk for AD (mean age 65 years old, 50% female) who underwent 26 weeks of supervised treadmill training. Systemic biomarkers implicated in learning and memory, including the myokine Cathepsin B (CTSB), brain-derived neurotrophic factor (BDNF), and klotho, as well as metabolomics were evaluated. Here we show that aerobic exercise training increases plasma CTSB and that changes in CTSB, but not BDNF or klotho, correlate with cognitive performance. BDNF levels decreased with exercise training. Klotho levels were unchanged by training, but closely associated with change in VO2peak. Metabolomic analysis revealed increased levels of polyunsaturated free fatty acids (PUFAs), reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis, with exercise. Multiple metabolites (~30%) correlated with changes in BDNF, but not CSTB or klotho. The positive association between CTSB and cognition, and the modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function. Overall, our analyses indicate metabolic regulation of exercise-induced plasma BDNF changes and provide evidence that CTSB is a marker of cognitive changes in late middle-aged adults at risk for dementia.

P3-303: Effects of ab and Bdnf Val66Met on Episodic Memory, Hippocampal Volume and Serum BDNF in Preclinical Alzheimer’S Disease

2016 ◽  
Vol 12 ◽  
pp. P957-P958
Author(s):  
Yen Ying Lim ◽  
Stephanie R. Rainey-Smith ◽  
Simon M. Laws ◽  
Veer Gupta ◽  
Tenielle Porter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Episodic Memory ◽  
Hippocampal Volume ◽  
Preclinical Alzheimer’S Disease ◽  
Serum Bdnf

scholarly journals Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism

2016 ◽  
Vol 48 (2) ◽  
pp. 116-123 ◽  
Author(s):  
José R. Lemos ◽  
Cleber R. Alves ◽  
Sílvia B. C. de Souza ◽  
Julia D. C. Marsiglia ◽  
Michelle S. M. Silva ◽  
...  
Keyword(s):  
Blood Flow ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Vascular Reactivity ◽  
Aerobic Exercise Training ◽  
Peripheral Blood Flow ◽  
Peripheral Vascular ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
Serum Bdnf

Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDNF and TrkB are expressed in vascular endothelial cells and aerobic exercise training can increase serum BDNF, this study aimed to test the hypotheses: 1) Serum BDNF levels modulate peripheral blood flow; 2) The Val66Met BDNF polymorphism impairs exercise training-induced vasodilation. We genotyped 304 healthy male volunteers (Val66Val, n = 221; Val66Met, n = 83) who underwent intense aerobic exercise training on a running track three times/wk for 4 mo. We evaluated pre- and post-exercise training serum BDNF and proBDNF concentration, heart rate (HR), mean blood pressure (MBP), forearm blood flow (FBF), and forearm vascular resistance (FVR). In the pre-exercise training, BDNF, proBDNF, BDNF/proBDNF ratio, FBF, and FVR were similar between genotypes. After exercise training, functional capacity (V̇o2 peak) increased and HR decreased similarly in both groups. Val66Val, but not Val66Met, increased BDNF (interaction, P = 0.04) and BDNF/proBDNF ratio (interaction, P < 0.001). Interestingly, FBF (interaction, P = 0.04) and the FVR (interaction, P = 0.01) responses during handgrip exercise (HG) improved in Val66Val compared with Val66Met, even with similar responses of HR and MBP. There were association between BDNF/proBDNF ratio and FBF (r = 0.64, P < 0.001) and FVR (r = −0.58, P < 0.001) during HG exercise. These results show that peripheral vascular reactivity and serum BDNF responses to exercise training are impaired by the BDNF Val66Met polymorphism and such responsiveness is associated with serum BDNF concentrations in healthy subjects.

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