P2-431: RELATIONSHIP BETWEEN LOCAL RESTING STATE ACTIVITY, β-AMYLOID DEPOSITION AND MEMORY PERFORMANCE IN THE DZNE: LONGITUDINAL COGNITIVE IMPAIRMENT AND DEMENTIA STUDY (DELCODE)

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P877-P878
Author(s):  
Coraline D. Metzger ◽  
Martin Dyrba ◽  
Daniel Bittner ◽  
Xiaochen Hu ◽  
Frank Jessen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Resting State ◽  
Memory Performance ◽  
Amyloid Deposition ◽  
State Activity ◽  
Β Amyloid

scholarly journals Lower functional hippocampal redundancy in mild cognitive impairment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stephanie Langella ◽  
◽  
Muhammad Usman Sadiq ◽  
Peter J. Mucha ◽  
Kelly S. Giovanello ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Resting State ◽  
Memory Performance ◽  
Potential Mechanism ◽  
Network Efficiency ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
The Relationship

AbstractWith an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements within a system that provide alternative functionality in case of failure. As the hippocampus is one of the earliest sites affected by AD pathology, we hypothesized that functional hippocampal redundancy is protective against cognitive decline. We compared hippocampal functional redundancy derived from resting-state functional MRI networks in cognitively normal older adults, with individuals with early and late MCI, as well as the relationship between redundancy and cognition. Posterior hippocampal redundancy was reduced between cognitively normal and MCI groups, plateauing across early and late MCI. Higher hippocampal redundancy was related to better memory performance only for cognitively normal individuals. Critically, functional hippocampal redundancy did not come at the expense of network efficiency. Our results provide support that hippocampal redundancy protects against cognitive decline in aging.

scholarly journals Rapid β-Amyloid Deposition and Cognitive Impairment After Cholinergic Denervation in APP/PS1 Mice

2013 ◽  
Vol 72 (4) ◽  
pp. 272-285 ◽  
Author(s):  
Juan Jose Ramos-Rodriguez ◽  
Mar Pacheco-Herrero ◽  
Diana Thyssen ◽  
Maria Isabel Murillo-Carretero ◽  
Esther Berrocoso ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Amyloid Deposition ◽  
Β Amyloid

scholarly journals Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia

2013 ◽  
Vol 84 (12) ◽  
pp. 1357-1364 ◽  
Author(s):  
Jennifer L Whitwell ◽  
Val J Lowe ◽  
Joseph R Duffy ◽  
Edythe A Strand ◽  
Mary M Machulda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Amyloid Deposition ◽  
Progressive Aphasia ◽  
Β Amyloid

P1-397: Sleep Disordered Breathing, CSF P-TAU, Hippocampal Atrophy and β-Amyloid Deposition in Mild Cognitive Impairment Patients

2016 ◽  
Vol 12 ◽  
pp. P585-P586
Author(s):  
Omonigho Michael Bubu ◽  
James Mortimer ◽  
David Morgan ◽  
Skai Schwartz ◽  
Amy Borenstein ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Disordered Breathing ◽  
Amyloid Deposition ◽  
Hippocampal Atrophy ◽  
Β Amyloid ◽  
Disordered Breathing

scholarly journals Spatial relationships between white matter degeneration, amyloid load and cortical volume in amnestic mild cognitive impairment

2018 ◽  
Author(s):  
Ileana O Jelescu ◽  
Timothy M Shepherd ◽  
Dmitry S Novikov ◽  
Yu-Shin Ding ◽  
Benjamin Ades-Aron ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Diffusion Mri ◽  
Amnestic Mild Cognitive Impairment ◽  
Amyloid Deposition ◽  
Cortical Volume ◽  
Cortical Areas ◽  
Healthy Control ◽  
Β Amyloid

The spatial-temporal relationships between gray and white matter (WM) degeneration during preclinical and early symptomatic Alzheimer's disease are poorly understood. We characterized β-amyloid deposition, cortical volume and WM degeneration in 44 subjects including healthy control (N=23), amnestic mild cognitive impairment (aMCI) (N=19), and early Alzheimer's subjects (N=2). Integrated PET-MRI provided simultaneous measurement of 18F-Florbetapir uptake in cortical areas, regional brain volumes from structural MRI, and WM tract integrity metrics from diffusion MRI using biophysical modeling. Across the cohort of healthy control and aMCIs, cortical volumes correlated poorly with β-amyloid deposition in the same area (p < 0.05 only in the posterior cingulate and parietal lobe). WM degeneration correlated significantly with both amyloid and volume of connected cortical areas, but more strongly with volume. Diffusion MRI metrics for WM demyelination and/or axonal loss could therefore provide new biomarkers associated with clinical Alzheimer's conversion. These WM changes may represent sequential propagation of Alzheimer's neurodegeneration between functionally connected regions, and/or evidence of direct WM injury during the Alzheimer's pathology cascade.

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