scholarly journals P1-203: ASTROCYTIC AND NEURONAL GLUTAMATE TRANSPORTER EAAT2 DEFICIENCY CAUSES MEMORY DEFICITS AND ASTROCYTIC, BUT NOT NEURONAL, EAAT2 DEFICIENCY, IS ASSOCIATED WITH HUMAN AGING AND ALZHEIMER'S DISEASE GENE EXPRESSION PROFILES

2019 ◽  
Vol 15 ◽  
pp. P314-P315
Author(s):  
Ana C. Pereira
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Gene ◽  
Expression Profiles ◽  
Glutamate Transporter ◽  
Gene Expression Profiles ◽  
Memory Deficits ◽  
Human Aging ◽  
Neuronal Glutamate Transporter

scholarly journals Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole

2016 ◽  
Vol 22 (2) ◽  
pp. 296-305 ◽  
Author(s):  
A C Pereira ◽  
J D Gray ◽  
J F Kogan ◽  
R L Davidson ◽  
T G Rubin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Gene ◽  
Expression Profiles ◽  
Gene Expression Profiles

Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease

2007 ◽  
Vol 1127 ◽  
pp. 127-135 ◽  
Author(s):  
Wendy M. Brooks ◽  
Patrick J. Lynch ◽  
Catherine C. Ingle ◽  
Alexander Hatton ◽  
Piers C. Emson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metabolic Enzyme

Gene Expression Profiles of Entorhinal Cortex in Alzheimer’s Disease

2014 ◽  
Vol 29 (6) ◽  
pp. 526-532 ◽  
Author(s):  
Bingqian Ding ◽  
Yan Xi ◽  
Ming Gao ◽  
Zhenjiang Li ◽  
Chenyang Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Entorhinal Cortex ◽  
Expression Profiles ◽  
Gene Expression Profiles

scholarly journals Supervised pathway analysis of blood gene expression profiles in Alzheimer's disease

2019 ◽  
Vol 84 ◽  
pp. 98-108 ◽  
Author(s):  
Elaheh Moradi ◽  
Mikael Marttinen ◽  
Tomi Häkkinen ◽  
Mikko Hiltunen ◽  
Matti Nykter
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pathway Analysis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression

scholarly journals The middle temporal gyrus is transcriptionally altered in patients with Alzheimer’s Disease.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transcriptional Repression ◽  
Zinc Finger Protein ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
Middle Temporal Gyrus ◽  
Middle Temporal

We sought to understand, at the systems level and in an unbiased fashion, how gene expression was most different in the brains of patients with Alzheimer’s Disease (AD) by mining published microarray datasets (1, 2). Comparing global gene expression profiles between patient and control revealed that a set of 84 genes were expressed at significantly different levels in the middle temporal gyrus (MTG) of patients with Alzheimer’s Disease (1, 2). We used computational analyses to classify these genes into known pathways and existing gene sets, and to describe the major differences in the epigenetic marks at the genomic loci of these genes. While a portion of these genes is computationally cognizable as part of a set of genes up-regulated in the brains of patients with AD (3), many other genes in the gene set identified here have not previously been studied in association with AD. Transcriptional repression, both pre- and post-transcription appears to be affected; nearly 40% of these genes are transcriptional targets of MicroRNA-19A/B (miR-19A/B), the zinc finger protein 10 (ZNF10), or of the AP-1 repressor jun dimerization protein 2 (JDP2).

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