Long-Term Outcome of Bariatric Surgery in Morbidly Obese Adolescents: A Systematic Review and Meta-Analysis of 917 Patients with a Minimum of Three Years Follow-Up

Background and objectives: The long-term outcome of endodontic microsurgery (EMS) performed on root-filled teeth affected by post-treatment apical periodontitis (AP) has been a matter of debate, re-launched by the introduction of novel root-end filling materials which have been proven to improve the short-term outcome of EMS. The purpose of this systematic review and meta-analysis is to evaluate the clinical and radiographic long-term outcome of endodontic microsurgery in teeth diagnosed with secondary AP through radiographic evaluation. Materials and Methods: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion and exclusion criteria were defined a priori to select the best longitudinal evidence. Only randomized clinical trials (RCT) and prospective clinical studies (PCS), with a follow-up ≥ 2-year, and exhibiting well-established clinical and radiographic outcome criteria, were selected. Results: A total of 573 articles were obtained, from which 10 fulfill inclusion criteria: 6 PCS and 4 RCT. Meta-analysis showed a pooled proportion of success rate of 91.3%, from an overall amount of 453 treated teeth included in RCT; from overall 839 included teeth in PCS, a pooled success rate of 78.4% was observed, with the follow-up time ranging from 2 to 13-years. Survival rate outcomes varied from 79 to 100% for the same follow-up period. Five prognostic factors with influence on the outcome were disclosed: smoking habits, tooth location and type, absence/presence of dentinal defects, interproximal bone level, and root-end filling material. Conclusions: High success rates and predictable results can be expected when EMS is performed by trained endodontists, allowing good prognosis and preservation of teeth affected by secondary AP.

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Mid- and long-term outcome of Salter’s, Pemberton’s and Dega’s osteotomy for treatment of developmental dysplasia of the hip: a systematic review and meta-analysis

Hip International ◽

10.1177/1120700020942866 ◽

2020 ◽

pp. 112070002094286

Author(s):

Sophie R Merckaert ◽

Pierre-Yves Zambelli ◽

Shannon N Edd ◽

Starnoni Daniele ◽

Jolles Brigitte

Keyword(s):

Systematic Review ◽

Initial Treatment ◽

Meta Analysis ◽

Developmental Dysplasia ◽

Unfavourable Outcome ◽

Term Outcome ◽

Long Term Outcome ◽

Dysplasia Of The Hip

Introduction: Early diagnosis and early treatment have become the gold standard for management of developmental dysplasia of the hip. Surgery is required in case of failed initial treatment. Innominate pelvic osteotomy of Salter (SIO), Pemberton’s pericapsular osteotomy (PPO) and Dega’s acetabuloplasty (DA) are among the most used procedures. We performed a systematic review and meta-analysis of the past 57 years in order to assess the mid- and long-term outcome of these techniques. Methods: Studies met inclusion criteria if they: (1) reported at least 5 cases treated by 1 of the abovementioned surgical techniques; (2) included children aged between 1 and 8 years; (3) surgical indication was late detected DDH or a failed initial treatment; (4) presented a minimal follow-up of 24 months; (5) reported the radiological score of Severin and/or the clinical score of McKay. Clinical and radiological outcomes were dichotomised into favourable and unfavourable outcome and weighted summary rates were determined using meta-analysis models. Results: From a total of 7391 articles, 48 level of evidence grade IV articles were included in our review. A total of 2143 cases with a mean follow up of 112.4 months were included. Pooled Severin score indicated a statistically better outcome for PPO and DA compared to SIO ( p = 0.0003 and p = 0.002, respectively). By dichotomising the results in favourable and unfavourable outcome, PPO showed the best results ( p = 0.0002 vs. SIO, p = 0.01 vs. DA). Pooled McKay score showed a statistically better outcome for PPO and DA compared to SIO ( p < 0.0001 and p = 0.03, respectively) as well as better outcomes for PPO compared to DA ( p = 0.01). By dichotomising the results in favourable and unfavourable, PPO showed the best results. Conclusions: Even if our review demonstrates slightly better radiological and clinical results with the PPO, the currently available and limited data do not allow for clear recommendation towards one of these techniques.

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SUN-345 Long-term outcome of kidney transplantation among Iranian children: A systematic review and meta-analysis

Kidney International Reports ◽

10.1016/j.ekir.2020.02.883 ◽

2020 ◽

Vol 5 (3) ◽

pp. S342

Author(s):

R. Hoseini

Keyword(s):

Systematic Review ◽

Kidney Transplantation ◽

Meta Analysis ◽

Term Outcome ◽

Long Term Outcome ◽

Iranian Children

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Bariatric surgery in morbidly obese adolescents: long-term follow-up

International Journal of Pediatric Obesity ◽

10.3109/17477166.2011.606817 ◽

2011 ◽

Vol 6 (S1) ◽

pp. 65-69 ◽

Cited By ~ 18

Author(s):

Kurt Widhalm ◽

Maria Fritsch ◽

Harald Widhalm ◽

Gerd Silberhumer ◽

Sabine Dietrich ◽

...

Keyword(s):

Bariatric Surgery ◽

Morbidly Obese ◽

Obese Adolescents ◽

Long Term Follow Up

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Bariatric Surgery in Morbidly Obese Adolescents: a Systematic Review and Meta-analysis

Obesity Surgery ◽

10.1007/s11695-015-1581-2 ◽

2015 ◽

Vol 25 (5) ◽

pp. 860-878 ◽

Cited By ~ 116

Author(s):

Givan F. Paulus ◽

Loes E. G. de Vaan ◽

Froukje J. Verdam ◽

Nicole D. Bouvy ◽

Ton A. W. Ambergen ◽

...

Keyword(s):

Systematic Review ◽

Bariatric Surgery ◽

Meta Analysis ◽

Morbidly Obese ◽

Obese Adolescents

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Meta-analysis of gender effect for first-line chronomodulated 5-fluorouracil-leucovorin-oxaliplatin (ChronoFLO) compared with FOLFOX or constant infusion (conventional delivery, CONV) against metastatic colorectal cancer (MCC) in three international controlled phase III randomized trials (RT)

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.4112 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 4112-4112 ◽

Cited By ~ 1

Author(s):

F. Levi ◽

P. Innominato ◽

A. Poncet ◽

T. Moreau ◽

S. Iacobelli ◽

...

Keyword(s):

Liver Metastases ◽

Meta Analysis ◽

Progression Free Survival ◽

Phase Iii ◽

Constant Infusion ◽

Term Outcome ◽

Long Term Outcome ◽

Significant Difference

4112 Background: Gender predicted for the most effective schedule in a RT of ChronoFLO vs CONV against MCC: overall survival (OS) was significantly increased in men on chronoFLO vs FOLFOX, whereas the reverse was found in women (Giacchetti, JCO 2006). Methods: To assess the relevance of gender for patient (pt) outcome, meta-analysis was performed on individual pt data (IPD) from 3 RT in 845 MCC pts treated with chronoFLO vs CONV (346 F, 499 M at 36 centers in 1990–2002)(Lévi, JNCI 1994; Lancet 1997). Data bases were merged and updated at 9 y after inclusion of the 1st pt. Main prognostic factors were comparable in each RT according to gender and treatment arm (median age: 61y; PS=0, 46% pts; liver M, 85% pts; liver involvement >25%, 41% pts; lung M, 37% pts; CEA>10, 56% pts). Results: No significant difference was found according to delivery schedule or gender in the whole population for Response Rate (RR), Progression-Free Survival (PFS) and OS. However, men on chronoFLO had highest RR, longest PFS and OS. PFS and OS were highest in women on CONV ( Table ). The rate of complete macroscopic resections of liver metastases (R0+R1) was 12.5% in men on chronoFLO vs 7.8–8.5% in men on CONV or in women on either schedule. A complete histologic response of liver metastases was documented in 2.1% of the men on chronoFLO vs 0–1.1% in the other groups. The relative risk of an earlier death in men vs women was 0.76 [95% CL, 0.91 to 0.94] on chronoFLO and 1.24 [0.99 to 1.56] on CONV. Conclusions: This IPD meta-analysis of 3 RT in MCC with a minimum follow up of 5 years confirms that men benefit from chronoFLO as compared to CONV delivery, with regard to long term outcome and medico-surgical strategy. ChronoFLO should be preferred to conventional oxaliplatin-5-FU-LV schedules in men with MCC. Support: ARTBC Internationale, P. Brousse Hospital, Villejuif, France. [Table: see text] No significant financial relationships to disclose.

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