Psychophysiological Assessment of Stress Reactivity and Recovery in Anxiety Disorders

2021 ◽  
pp. 102426
Author(s):  
David F. Tolin ◽  
Eric Lee ◽  
Hannah C. Levy ◽  
Akanksha Das ◽  
Liya Mammo ◽  
...  
2017 ◽  
Vol 48 (6) ◽  
pp. 1020-1033 ◽  
Author(s):  
A. Ulmer-Yaniv ◽  
A. Djalovski ◽  
K. Yirmiya ◽  
G. Halevi ◽  
O. Zagoory-Sharon ◽  
...  

BackgroundChronic early trauma alters children's stress reactivity and increases the prevalence of anxiety disorders; yet the neuroendocrine and immune mechanisms underpinning this effect are not fully clear. Animal studies indicate that the mother's physiology and behavior mediate offspring stress in a system-specific manner, but few studies tested this external-regulatory maternal role in human children exposed to chronic stress.MethodsWe followed a unique cohort of children exposed to continuous wartime trauma (N= 177; exposed;N= 101, controls;N= 76). At 10 years, maternal and child's salivary immunoglobulin A (s-IgA) and oxytocin (OT), biomarkers of the immune and affiliation systems, were assayed, maternal and child relational behaviors observed, mother and child underwent psychiatric diagnosis, and child anxiety symptoms assessed.ResultsWar-exposed mothers had higher s-IgA, lower OT, more anxiety symptoms, and their parenting was characterized by reduced sensitivity. Exposed children showed higher s-IgA, more anxiety disorders and post traumatic stress disorder, and more anxiety symptoms. Path analysis model defined three pathways by which maternal physiology and behavior impacted child anxiety; (a) increasing maternal s-IgA, which led to increased child s-IgA, augmenting child anxiety; (b) reducing maternal OT, which linked with diminished child OT and social repertoire; and (c) increasing maternal anxiety, which directly impacted child anxiety.ConclusionsOur findings, the first to measure immune and affiliation biomarkers in mothers and children, detail their unique and joint effects on children's anxiety in response to stress; highlight the relations between chronic stress, immune activation, and anxiety in children; and describe how processes of biobehavioral synchrony shape children's long-term adaptation.


2017 ◽  
Author(s):  
Steven Barnes ◽  
Julie Prescott

BACKGROUND Extant evidence suggests that the proportion of adolescents suffering from anxiety disorders (ADs) has increased by up to 70% since the mid-1980s, with experience of anxiety at this stage associated with significant negative short- and long-term life outcomes. The existing therapeutic interventions (eg, cognitive behavioral therapy, CBT; attention bias modification, ABM) have proven to have clinically measurable benefits in reducing anxiety, but their efficacy is often compromised by social and practical barriers. The growing discrepancy between demand for, and access to, clinical interventions for anxiety has led to the development of a range of eHealth (health care practice supported by electronic processes and communication) and mHealth (versions of eHealth using mobile devices) interventions. One such protocol is therapeutic games, which aim to provide clinical frameworks in dynamic, adaptable, and personalized virtual environments. Although some evidence exists to suggest therapeutic games are associated with reductions in subjective anxiety and observed stress reactivity, there is currently, to our knowledge, no systematic review of the adherence to, and effectiveness of, therapeutic games for adolescent anxiety. OBJECTIVE The aim of this review was to establish the effectiveness of therapeutic games in making clinically measurable reductions in anxiety symptoms in adolescent samples. METHODS A systematic search of the existing academic literature published between 1990 and July 2017 was conducted using the databases Journal of Medical Internet Research, Journal Storage, Psychology Articles, Psychology Info, ScienceDIRECT, and Scopus. Records linked to empirical papers on therapeutic games for anxiety using adolescent samples were evaluated. RESULTS A total of 5 studies (N=410 participants) met the inclusion criteria, and 3 gamified anxiety interventions for adolescents were identified. The papers included a mixture of randomized controlled trials, quasi-experimental studies, and usability studies comprising quantitative and qualitative measures, with varying degrees of mixed methods. Extant evidence shows potential for therapeutic games to create clinically measurable reductions in symptoms of anxiety in adolescent samples, though findings are complicated in some cases by a low sample size, and in other cases by research design and methodological complications, including anxiety reductions in control groups caused by a control-game selection. CONCLUSIONS Although research in this field appears to be extremely limited, as demonstrated by the small number of papers meeting the inclusion criteria for this review, early findings suggest that therapeutic games have potential in helping to engage adolescents with anxiety and lead to clinically measurable reductions in symptoms.


1998 ◽  
Vol 77 (10) ◽  
pp. 1840-1850 ◽  
Author(s):  
R. Ohrbach ◽  
J. Blascovich ◽  
E.N. Gale ◽  
W.D. McCall ◽  
S.F. Dworkin

2006 ◽  
Vol 26 (4) ◽  
pp. 414-418 ◽  
Author(s):  
Simon J.C. Davies ◽  
Sean D. Hood ◽  
Spilios V. Argyropoulos ◽  
Kelly Morris ◽  
Caroline Bell ◽  
...  

2019 ◽  
Vol 272 ◽  
pp. 756-764 ◽  
Author(s):  
Diana Koszycki ◽  
Monica Taljaard ◽  
Catherine Bielajew ◽  
Robert M. Gow ◽  
Jacques Bradwejn

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