HPV Test Result Monitoring of Different Bethesda Categories in Gynecologic Cytology: A Valuable Quality Assurance Measure

ObjectiveFrom December 2017, the Australian National Cervical Screening Program commenced 5 yearly primary human papillomavirus (HPV) screening; one of the first high-income countries to implement primary HPV screening. This study aimed to examine the psychosocial impact of self-reporting testing HPV positive in a sample of women screened since the renewal of the programme.MethodsWomen in Australia aged 25–74 years who reported participating in cervical screening since December 2017 were recruited through an online market research company to complete a cross-sectional survey. The primary outcomes were anxiety and general distress.Results1004 women completed the online survey; 80.9% reported testing HPV negative (HPV−), 6.5% reported testing HPV positive (HPV+) and 12.9% did not know/remember their test result. Women who reported testing HPV+ had significantly poorer psychological outcomes on a range of measures. Those who reported testing HPV+ had higher anxiety scores (53.03 vs 43.58 out of 80, p<0.001), showed more general distress (3.94 vs 2.52 out of 12, p=0.004), concern about their test result (5.02 vs 2.37, p<0.001), expressed greater distress about their test result (7.06 vs 4.74, p<0.001) and cancer worry (quite or very worried 35.4% vs 11.6%, p<0.001) than women who reported testing HPV−. Concern regarding test results was also significantly higher in women who did not know/remember their test result (3.20 vs 2.37, p<0.001) compared with women who reported testing HPV−. Women who reported testing HPV+ had greater knowledge of HPV (9.25 vs 6.62, p<0.001) and HPV testing (2.44 vs 1.30, p<0.001) than women who reported testing HPV−.ConclusionsReceipt of an HPV+ test result was associated with high levels of anxiety and distress, which reached clinical significance. Further work is needed to understand whether distress and concern could be reduced by ensuring all women receive high-quality standardised information with their results or by other interventions.

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Evaluation of the 10% rescreen of negative gynecologic smears as a quality assurance measure

Diagnostic Cytopathology ◽

10.1002/(sici)1097-0339(199602)14:1<84::aid-dc17>3.0.co;2-9 ◽

1996 ◽

Vol 14 (1) ◽

pp. 84-86 ◽

Cited By ~ 12

Author(s):

Sana O. Tabbara ◽

Mary K. Sidawy

Keyword(s):

Quality Assurance ◽

Quality Assurance Measure

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HPV co-testing as cervical screening test, Experience of Alweiya early detection cervical clinic: one-year Analysis

Journal of Contemporary Medical Sciences ◽

10.22317/jcms.v6i5.859 ◽

2020 ◽

Vol 6 (5) ◽

Author(s):

Zainab J Al-Jobawi ◽

Besmah M. Ali ◽

Asan A Al-Niyazee ◽

Mustafa H Ibraheem

Keyword(s):

High Risk ◽

Screening Program ◽

Test Results ◽

Abnormal Cytology ◽

Normal Cytology ◽

Papilloma Virus ◽

Hpv Test ◽

Primary Test ◽

The Difference ◽

Test Result

Objectives: The high-risk Human papilloma virus test with conventional cytology (HPVco-test) was firstly introduced in our institute at May 2019 so we aimed to estimate the prevalence of abnormal cytology and positive high-risk human papillomavirus test results in a screening woman and to assess the accuracy between cytology and Human papilloma virus testing to evaluate the feasibility of integrating the latter as a primary test in the national cervical cancer screening program. Methods: A prospective study for women attending to early detection cervical clinic, during the period from May 2019 to May 2020. Patients who were sexually active were included in the study. Samples for conventional cytology and HPV by using real-time polymerase chain reaction technique for high risk types were taken concurrently. The prevalence of positive screening results and the difference in accuracy between two testing were estimated by McNemar’s χ2 test. Result: A total of 388 women were included in the study. The prevalence of positive test for hr-HPV was 2.1%(8) while the prevalence of abnormal cytology test was 19.1%(74), Concerning discordant pairs, 0.8%(3) of women had normal cytology with a positive hr-HPV test result and 17.8%(69) of women had abnormal cytology with a negative hr-HPV test result. A total of 311 (80.1%) women had normal cytology and negative hr-HPV test results. The proportion of women with abnormal cytology and positive hr-HPV test results was 1.3% (5 women). the difference in accuracy between the two results was statistically significant (<0.0001). The prevalence of positive hr-HPV test decreased with increasing age, whereas the prevalence of abnormal cytology showed a bimodal age pattern. Conclusion: The prevalence of abnormal cytology was high to that of hr-HPV testing, which could not allow for the implementation of hr-HPV as a primary test in the national screening program in Iraq.

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Tumor Cellularity as a Quality Assurance Measure for Accurate Clinical Detection of BRAF Mutations in Melanoma

Molecular Diagnosis & Therapy ◽

10.1007/s40291-014-0091-6 ◽

2014 ◽

Vol 18 (4) ◽

pp. 409-418 ◽

Cited By ~ 20

Author(s):

Jonathan C. Dudley ◽

Grzegorz T. Gurda ◽

Li-Hui Tseng ◽

Derek A. Anderson ◽

Guoli Chen ◽

...

Keyword(s):

Quality Assurance ◽

Braf Mutations ◽

Quality Assurance Measure ◽

Clinical Detection

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Estimation of Diffusion Losses when Sampling Diesel Aerosol: A Quality Assurance Measure

10.4271/2003-01-1896 ◽

2003 ◽

Cited By ~ 6

Author(s):

Alberto Ayala ◽

Bernard Olson ◽

Bruce Cantrell ◽

Marcus Drayton ◽

Nicholas Barsic

Keyword(s):

Quality Assurance ◽

Quality Assurance Measure

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Number of Excised Lymph Nodes as a Quality Assurance Measure for Lymphadenectomy in Melanoma

JAMA Surgery ◽

10.1001/jamasurg.2013.5676 ◽

2014 ◽

Vol 149 (7) ◽

pp. 700 ◽

Cited By ~ 27

Author(s):

Carlo Riccardo Rossi ◽

Nicola Mozzillo ◽

Andrea Maurichi ◽

Sandro Pasquali ◽

Giuseppe Macripò ◽

...

Keyword(s):

Quality Assurance ◽

Lymph Nodes ◽

Quality Assurance Measure

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Risk Factors for Cervical Human Papillomavirus Infection and High-Grade Intraepithelial Lesion in Women Aged 20 to 31 Years in Germany

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e318285a4b2 ◽

2013 ◽

Vol 23 (3) ◽

pp. 519-526 ◽

Cited By ~ 18

Author(s):

Cornelius Remschmidt ◽

Andreas M. Kaufmann ◽

Ingke Hagemann ◽

Elena Vartazarova ◽

Ole Wichmann ◽

...

Keyword(s):

Risk Factors ◽

Genital Warts ◽

Hpv Infection ◽

Older Age ◽

High Grade ◽

Negative Group ◽

Positive Group ◽

Hpv Test ◽

Intraepithelial Lesion ◽

Test Result

BackgroundPersistent infection with high-risk human papillomaviruses (HPVs) can lead to cervical intraepithelial lesion and cervical cancer. Sexual behavior and smoking have been identified as risk factors for HPV infection. However, it is unclear which factors account for the persistence of HPV infection and for high-grade squamous intraepithelial lesions (HSIL). Therefore, we conducted a study to identify epidemiological risk factors for the following: (1) the presence of HPV among women without a recent diagnosis of HSIL and (2) HSIL.Materials and MethodsParticipants aged 20 to 31 years were recruited at 2 study sites. All women received a cervical Papanicolaou test, were tested for HPV, and categorized into 1 of 3 different groups: The women of the first group had negative cytological test results and a negative HPV test result (HPV-negative group), and the women of the second group had negative cytological test result but positive HPV test result (HPV-positive group). The third group consisted of women with a diagnosis of HSIL (HSIL group). We first compared the HPV-negative group with the HPV-positive group, and then the HPV-positive group with the HSIL group.ResultsOne hundred forty-seven women were included: 53 women in the HPV-negative group, 46 women in the HPV-positive group, and 48 women in the HSIL group. Comparing the HPV-negative with the HPV-positive group, we found that more than 5 sexual partners during a lifetime were independently associated with cervical HPV infection, whereas the chance of being infected decreased with older age. Irregular condom use during one-night stands or smoking was associated with HPV infection only in univariable but not multivariable analysis. In contrast, older age and having had genital warts were independently associated with an HSIL diagnosis when comparing the HPV-positive group with the HSIL group.DiscussionAlthough the study was hampered by its relatively small sample size, our data suggest that main risk factors for the acquisition of HPV infection are a higher number of sexual partners and younger age, whereas older age and genital warts may be epidemiological cofactors in the development of HSIL.

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