The lack of toll-like receptor 4 promotes up-regulation and delocalization of neutral sphingomyelinase in the MPTP mouse model of Parkinson's disease

2019 ◽  
Vol 305 ◽  
pp. S27
Author(s):  
M. Codini ◽  
S. Cataldi ◽  
I. Ferri ◽  
M. Laurenti ◽  
M. Ceccarini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Neutral Sphingomyelinase

247 The Role of Toll-Like Receptor-4 in Gut-Brain Cross Talk in a Murine Model of Parkinson's Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-59
Author(s):  
Paula Perez-Pardo ◽  
Hidde Douna ◽  
Tom Wijnands ◽  
Sofia Lopes da Silva ◽  
Christopher B. Forsyth ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cross Talk ◽  
Murine Model ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Samuela Cataldi ◽  
Cataldo Arcuri ◽  
Stéphane Hunot ◽  
François-Pierre Légeron ◽  
Carmen Mecca ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dihydroxyvitamin D3 ◽  
Neutral Sphingomyelinase ◽  
Proliferation And Apoptosis ◽  
Rigid Molecule ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Stimulation Of

Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains undetected. In this study, we show an upregulation of inducible nitric oxide synthase and a downregulation of neutral sphingomyelinase in the hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of Parkinson’s disease. Moreover, the stimulation of neutral sphingomyelinase activity with vitamin 1,25-dihydroxyvitamin D3 reduces specifically saturated fatty acid sphingomyelin by making sphingomyelin a less rigid molecule that might influence neurite plasticity. The possible biological relevance of the increase of neutral sphingomyelinase in Parkinson’s disease is discussed.

scholarly journals Toll-Like Receptor Expression in the Blood and Brain of Patients and a Mouse Model of Parkinson's Disease

2014 ◽  
Vol 18 (6) ◽  
pp. pyu103-pyu103 ◽  
Author(s):  
J. Drouin-Ouellet ◽  
I. St-Amour ◽  
M. Saint-Pierre ◽  
J. Lamontagne-Proulx ◽  
J. Kriz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Receptor Expression ◽  
Toll Like Receptor
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