Simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma by liquid chromatography–tandem mass spectrometry for pharmacokinetic studies

2007 ◽  
Vol 852 (1-2) ◽  
pp. 85-91 ◽  
Author(s):  
Ruolan Gu ◽  
Guifang Dou ◽  
Jing Wang ◽  
Junxing Dong ◽  
Zhiyun Meng
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Active Metabolites ◽  
Chromatography Tandem Mass Spectrometry ◽  
Dicaffeoylquinic Acid ◽  
Liquid Chromatography Tandem Mass

Enantioselective determination of lercanidipine in human plasma for pharmacokinetic studies by normal-phase liquid chromatography–tandem mass spectrometry

2003 ◽  
Vol 796 (2) ◽  
pp. 429-437 ◽  
Author(s):  
Valquiria Aparecida Polisel Jabor ◽  
Eduardo Barbosa Coelho ◽  
Demian Rocha Ifa ◽  
Pierina Sueli Bonato ◽  
Neife Aparecida Guinaim dos Santos ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Normal Phase ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Phase Liquid

scholarly journals Quantitative Determination of Quinocetone and Its Metabolites in Chicken Plasma by Liquid Chromatography/Tandem Mass Spectrometry

2008 ◽  
Vol 91 (6) ◽  
pp. 1494-1498 ◽  
Author(s):  
Yong Li ◽  
Zhi Xian Gao ◽  
FangTing Dong ◽  
Yi Yong Cheng
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Multiple Reaction Monitoring ◽  
Veterinary Drug ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Abstract A new method has been established for the simultaneous determination of the new veterinary drug quinocetone (3-methyl-2-cinnamoyl-N-1,4-dioxyquioxaline; QTN) and its 2 metabolites de-monoxy-quinocetone (3-methyl-2-cinnamoyl-N-1-monoxyquinoxaline; DMO-QTN) and de-dioxyquinocetone (3-methyl-2-cinnamoyl-N-quinoxaline; DDI-QTN) in chicken plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The detection was performed using electrospray ionization in multiple reaction monitoring mode. The analysis of the linearity, accuracy, and precision of the method is described. The limits of detection and quantification of the LC/MS/MS method used for testing QTN, DMO-QTN, and DDI-QTN were 0.002 and 0.008 g/mL; 0.002 and 0.008 g/mL; and 0.003 and 0.010 g/mL, respectively. The method was validated and can be used in future pharmacokinetic studies.

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