scholarly journals Detection of 1,N2-propano-2′-deoxyguanosine in human urine by stable isotope dilution UHPLC–MS/MS analysis

2016 ◽  
Vol 1023-1024 ◽  
pp. 68-71 ◽  
Author(s):  
Ning Zhang ◽  
Yuanyuan Song ◽  
Weibing Zhang ◽  
Hailin Wang
Keyword(s):  
Stable Isotope ◽  
Isotope Dilution ◽  
Human Urine ◽  
Stable Isotope Dilution ◽  
Ms Analysis

scholarly journals Quantification of α-Thujone and Its Metabolites in Human Urine after Consumption of a Sage Infusion Using Stable Isotope Dilution Assays

Toxins ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 511 ◽  
Author(s):  
Irene Thamm ◽  
Konrad Tiefenbacher ◽  
Michael Rychlik
Keyword(s):  
Detection Limit ◽  
Stable Isotope ◽  
Isotope Dilution ◽  
Human Urine ◽  
Maximum Concentration ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Internal Standard ◽  
Stable Isotope Dilution ◽  
Stable Isotope Dilution Assays

The metabolism of the monoterpene α-thujone was investigated in humans after consumption of sage tea, by analyses of its metabolites 2-hydroxythujone, 4-hydroxythujone, and 7-hydroxythujone in urine. For the quantitation of α-thujone and its metabolites, stable isotope dilution assays were developed. Using d6-α-thujone as internal standard, we quantified α-thujone by solid phase microextraction GC-MS and the hydroxythujones with d6-2-hydroxythujone, d6-4-hydroxythujone, and d6-7-hydroxythujone after glucuronide/sulfate deconjugation by LC-MS/MS in urine. After the consumption of 575.0 µg α-thujone, the 4-hydroxythujone and 7-hydroxythujone were detectable in the urine of the volunteers under study, after liberation from their glucuronides/sulfates. The 2-Hydroxythujone was not present in any of the volunteer samples above its detection limit. α-Thujone was detectable in a low amount, with a maximum concentration of 94 ng/L for the volunteer with the highest dose of 14.3 µg/kg bw.

scholarly journals Detection of Human Urinary 5-Hydroxymethylcytosine by Stable Isotope Dilution HPLC-MS/MS Analysis

2015 ◽  
Vol 87 (3) ◽  
pp. 1846-1852 ◽  
Author(s):  
Ruichuan Yin ◽  
Jiezhen Mo ◽  
Meiling Lu ◽  
Hailin Wang
Keyword(s):  
Stable Isotope ◽  
Isotope Dilution ◽  
Stable Isotope Dilution ◽  
Ms Analysis

Targeted stable-isotope dilution GC–MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma

2009 ◽  
Vol 877 (26) ◽  
pp. 2909-2923 ◽  
Author(s):  
Alexander A. Zoerner ◽  
Frank M. Gutzki ◽  
Maria T. Suchy ◽  
Bibiana Beckmann ◽  
Stefan Engeli ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Stable Isotope ◽  
Human Plasma ◽  
Isotope Dilution ◽  
Stable Isotope Dilution ◽  
Ms Analysis
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