scholarly journals Renal Denervation Using an Irrigated Radiofrequency Ablation Catheter for Management of Drug-Resistant Hypertension

2012 ◽  
Vol 5 (7) ◽  
pp. 766-768 ◽  
Author(s):  
Edward D. Frohlich
Author(s):  
Rodolfo Staico ◽  
Luciana Armaganijan ◽  
Dalmo Moreira ◽  
Marcio Sousa ◽  
Flavio Borelli ◽  
...  

2018 ◽  
Vol 28 (8) ◽  
pp. 3355-3361 ◽  
Author(s):  
Monica Sigovan ◽  
Salim Si-Mohamed ◽  
Pierre-Yves Courand ◽  
Brahim Harbaoui ◽  
Marc Sapoval ◽  
...  

2014 ◽  
Vol 23 (3) ◽  
pp. 138-146 ◽  
Author(s):  
Yu Jin ◽  
Lotte Jacobs ◽  
Marie Baelen ◽  
Lutgarde Thijs ◽  
Jean Renkin ◽  
...  

2013 ◽  
Vol 34 (28) ◽  
pp. 2114-2121 ◽  
Author(s):  
Márcio Galindo Kiuchi ◽  
George Luiz Marques Maia ◽  
Maria Angela Magalhães de Queiroz Carreira ◽  
Tetsuaki Kiuchi ◽  
Shaojie Chen ◽  
...  

2016 ◽  
Vol 34 ◽  
pp. e48 ◽  
Author(s):  
M.D. Lobo ◽  
J. Montarello ◽  
M. Saxena ◽  
A. Jain ◽  
D. Walters ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Noel Pérez ◽  
Karl Muffly ◽  
Stephen E. Saddow

Abstract Background Renal denervation with radiofrequency ablation has become an accepted treatment for drug-resistant hypertension. However, there is a continuing need to develop new catheters for high-accuracy, targeted ablation. We therefore developed a radiofrequency bipolar electrode for controlled, targeted ablation through Joule heating induction between 60 and 100 °C. The bipolar design can easily be assembled into a basket catheter for deployment inside the renal artery. Methods Finite element modeling was used to determine the optimum catheter design to deliver a minimum ablation zone of 4 mm (W) × 10 mm (L) × 4 mm (H) within 60 s with a 500 kHz, 60 Vp-p signal, and 3 W maximum. The in silico model was validated with in vitro experiments using a thermochromic phantom tissue prepared with polyacrylamide gel and a thermochromic ink additive that permanently changes from pink to magenta when heated over 60 °C. Results The in vitro ablation zone closely matched the size and shape of the simulated area. The new electrode design directs the current density towards the artery walls and tissue, reducing unwanted blood temperature increases by focusing energy on the ablation zone. In contrast, the basket catheter design does not block renal flow during renal denervation. Conclusions This computational model of radiofrequency ablation can be used to estimate renal artery ablation zones for highly targeted renal denervation in patients with resistant hypertension. Furthermore, this innovative catheter has short ablation times and is one of the lowest power requirements of existing designs to perform the ablation.


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