Cultured skin loaded with tetracycline HCl and chloramphenicol as dermal delivery system: Mathematical evaluation of the cultured skin containing antibiotics

Propolis is a resinous substance produced by bees that exhibits antimicrobial, immunostimulatory and antioxidant activity. Its use is common in functional foods, cosmetics and traditional medicine despite the fact that it demonstrates low extraction yields and inconsistency in non-toxic solvents. In this work, a new encapsulation and delivery system consisting of liposomes and cyclodextrins incorporating propolis polyphenols has been developed and characterized. The antioxidant, antimutagenic and antiaging properties of the system under normal and UVB-induced oxidative stress conditions were investigated in cultured skin cells and/or reconstituted skin model. Furthermore, the transcript accumulation for an array of genes involved in many skin-related processes was studied. The system exhibits significant polyphenol encapsulation efficiency, physicochemical stability as well as controlled release rate in appropriate conditions. The delivery system can retain the anti-mutagenic, anti-oxidative and anti-ageing effects of propolis polyphenols to levels similar and comparable to those of propolis methanolic extracts, making the system ideal for applications where non-toxic solvents are required and controlled release of the polyphenol content is desired.

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Improvement of Lax Skin using a High-Pressure Pneumatic Dermal Delivery System

Medical Lasers ◽

10.25289/ml.2016.5.2.96 ◽

2016 ◽

Vol 5 (2) ◽

pp. 96-100 ◽

Cited By ~ 1

Author(s):

Ik Jun Moon ◽

Ji Su Yu ◽

Won Ah Choi ◽

Tai Kyung Noh ◽

Woo Jin Lee ◽

...

Keyword(s):

High Pressure ◽

Delivery System ◽

Dermal Delivery

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Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochloride

Acta Pharmaceutica ◽

10.2478/v10007-011-0025-3 ◽

2011 ◽

Vol 61 (3) ◽

pp. 271-282 ◽

Cited By ~ 15

Author(s):

Bazigha Rasool ◽

Uday Aziz ◽

Omar Sarheed ◽

Alaa Rasool

Keyword(s):

Delivery System ◽

Transdermal Delivery ◽

Skin Irritation ◽

Chitosan Film ◽

Penetration Enhancers ◽

Propranolol Hydrochloride ◽

Moisture Uptake ◽

Rat Skin ◽

Uptake Capacity ◽

Dermal Delivery

Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochlorideThe objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL)viaemploying chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated. Skin irritation of the candidate film was evaluated. Chitosan film (PPL 2 mg cm-2, chitosan 2 %,m/m, cineol 10 %,m/m) was found nonirritant and achieved 88.2 % release after 8 hours in phosphate buffer. Significant high (p< 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor), making it a promising trans-dermal delivery system for PPL.

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