Antibiotic dosing in sustained low-efficiency daily dialysis (SLEDD): Basic concepts and dosing strategies

2022 ◽  
Vol 67 ◽  
pp. 104-107
Author(s):  
Anna Lee ◽  
Jan J. De Waele ◽  
Jeffrey Lipman
Keyword(s):  
Daily Dialysis ◽  
Dosing Strategies ◽  
Basic Concepts ◽  
Low Efficiency ◽  
Antibiotic Dosing

Antibiotic dosing during sustained low-efficiency dialysis: Special considerations in adult critically ill patients*

2011 ◽  
Vol 39 (3) ◽  
pp. 560-570 ◽  
Author(s):  
Kimberly N. Bogard ◽  
Nicole T. Peterson ◽  
Troy J. Plumb ◽  
Michael W. Erwin ◽  
Patrick D. Fuller ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Low Efficiency ◽  
Antibiotic Dosing

70 Sustained Low Efficiency Daily Dialysis (SLEDD) in the ICU: Outcomes Compared to Intermittent Hemodialysis (IHD)

2011 ◽  
Vol 57 (4) ◽  
pp. B34
Author(s):  
George Coritsidis ◽  
Andrew Chao ◽  
Dharmesh Sutariya ◽  
Alan Hola ◽  
Sudhanshu Jain ◽  
...  
Keyword(s):  
Intermittent Hemodialysis ◽  
Daily Dialysis ◽  
Low Efficiency

Sustained low-efficiency daily dialysis with hemofiltration for acute kidney injury in the presence of sepsis

2008 ◽  
Vol 69 (01) ◽  
pp. 40-46 ◽  
Author(s):  
B.G. Holt ◽  
J.J. White ◽  
A. Kuthiala ◽  
P. Fall ◽  
H.M. Szerlip
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Daily Dialysis ◽  
Low Efficiency

scholarly journals Global antibiotic dosing strategies in hospitalised children: Characterising variation and implications for harmonisation of international guidelines

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252223
Author(s):  
Michelle N. Clements ◽  
Neal Russell ◽  
Julia A. Bielicki ◽  
Sally Ellis ◽  
Silke Gastine ◽  
...  
Keyword(s):  
Future Research ◽  
Actual Weight ◽  
Intravenous Antibiotics ◽  
Dosing Strategies ◽  
Health Communities ◽  
Using Data ◽  
Dosing Strategy ◽  
Historical Variation ◽  
Tract Infections ◽  
Antibiotic Dosing

Background Paediatric global antibiotic guidelines are inconsistent, most likely due to the limited pharmacokinetic and efficacy data in this population. We investigated factors underlying variation in antibiotic dosing using data from five global point prevalence surveys. Methods & findings Data from 3,367 doses of the 16 most frequent intravenous antibiotics administered to children 1 month–12 years across 23 countries were analysed. For each antibiotic, we identified standard doses given as either weight-based doses (in mg/kg/day) or fixed daily doses (in mg/day), and investigated the pattern of dosing using each strategy. Factors underlying observed variation in weight-based doses were investigated using linear mixed effects models. Weight-based dosing (in mg/kg/day) clustered around a small number of peaks, and all antibiotics had 1–3 standard weight-based doses used in 5%-48% of doses. Dosing strategy was more often weight-based than fixed daily dosing for all antibiotics apart from teicoplanin, which had approximately equal proportions of dosing attributable to each strategy. No strong consistent patterns emerged to explain the historical variation in actual weight-based doses used apart from higher dosing seen in central nervous system infections, and lower in skin and soft tissue infections compared to lower respiratory tract infections. Higher dosing was noted in the Americas compared to the European region. Conclusions Antibiotic dosing in children clusters around a small number of doses, although variation remains. There is a clear opportunity for the clinical, scientific and public health communities to consolidate behind a consistent set of global antibiotic dosing guidelines to harmonise current practice and prioritise future research.

scholarly journals Population Pharmacokinetics of Piperacillin in Sepsis Patients: Should Alternative Dosing Strategies Be Considered?

2018 ◽  
Vol 62 (5) ◽  
Author(s):  
Maria Goul Andersen ◽  
Anders Thorsted ◽  
Merete Storgaard ◽  
Anders N. Kristoffersson ◽  
Lena E. Friberg ◽  
...  
Keyword(s):  
Free Drug ◽  
Free Drug Concentration ◽  
Total Clearance ◽  
Prolonged Infusion ◽  
Target Attainment ◽  
Content Type ◽  
Optimal Dosing ◽  
Dosing Regimens ◽  
Dosing Strategies ◽  
Antibiotic Dosing

ABSTRACTSufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) variability seen in septic patients, optimal dosing may be a challenge. We determined the PK profile for piperacillin given at 4 g every 8 h in 22 septic patients admitted to a medical ward. Piperacillin concentrations were compared to the clinical breakpoint MIC forPseudomonas aeruginosa(16 mg/liter), and the following PK/pharmacodynamic (PD) targets were evaluated: the percentage of the dosing interval that the free drug concentration is maintained above the MIC (fTMIC) of 50% and 100%. A two-compartment population PK model described the data well, with clearance being divided into renal and nonrenal components. The renal component was proportional to the estimated creatinine clearance (eCLCR) and constituted 74% of the total clearance in a typical individual (eCLCR, 83.9 ml/min). Patients with a high eCLCR(>130 ml/min) were at risk of subtherapeutic concentrations for the current regimen, with a 90% probability of target attainment being reached at MICs of 2.0 (50%fTMIC) and 0.125 mg/liter (100%fTMIC). Simulations of alternative dosing regimens and modes of administration showed that dose increment and prolonged infusion increased the chance of achieving predefined PK/PD targets. Alternative dosing strategies may therefore be needed to optimize piperacillin exposure in septic patients. (This study has been registered at ClinicalTrials.gov under identifier NCT02569086.)

scholarly journals Treatment of metformin-associated lactic acidosis with sustained low-efficiency daily dialysis

2008 ◽  
Vol 1 (5) ◽  
pp. 380-381
Author(s):  
A. Teutonico ◽  
P. Libutti ◽  
C. Lomonte ◽  
M. Antonelli ◽  
F. Casucci ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Daily Dialysis ◽  
Low Efficiency

Survey of pharmacists’ antibiotic dosing recommendations for sustained low-efficiency dialysis

2015 ◽  
Vol 38 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Jian P. Mei ◽  
Azadeh Ali-Moghaddam ◽  
Bruce A. Mueller
Keyword(s):  
Low Efficiency ◽  
Antibiotic Dosing

scholarly journals Antibiotic Dosing in Slow Extended Daily Dialysis

2009 ◽  
Vol 49 (3) ◽  
pp. 433-437 ◽  
Author(s):  
David M. Mushatt ◽  
Linda B. Mihm ◽  
Albert W. Dreisbach ◽  
Eric E. Simon
Keyword(s):  
Daily Dialysis ◽  
Antibiotic Dosing

Inadequate antibiotic dosing in patients receiving sustained low efficiency dialysis

2018 ◽  
Vol 40 (5) ◽  
pp. 1250-1256 ◽  
Author(s):  
Leigh Anne Keough ◽  
Amy Krauss ◽  
Joanna Q. Hudson
Keyword(s):  
Low Efficiency ◽  
Antibiotic Dosing
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