Prospective comparative evaluation of povidone–iodine (10% for 5 minutes versus 5% for 1 minute) as prophylaxis for ophthalmic surgery

Purpose:To evaluate the bactericidal activity of a diluted povidone-iodine formulation (0.6%) in comparison with the most used 5% povidone-iodine solution ophthalmic preparation.Methods:In vitro bactericidal activity comparison between 0.6% povidone-iodine versus 5% povidone-iodine formulations, against these bacteria: Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300, Staphylococcus epidermidis ATCC 12228, linezolid-resistant Staphylococcus epidermidis α99 strain, a clinical isolate, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922.Results:About 0.6% povidone-iodine formulation was demonstrated to be faster than 5% povidone-iodine preparation in killing Gram-positive as well as Gram-negative bacteria. Against a linezolid-resistant methicillin-resistant Staphylococcus epidermidis strain, 0.6% povidone-iodine formulation showed the best antiseptic efficacy requirement of 3-log10reduction in bacterial load, if compared with the 5% povidone-iodine formulation.Conclusion:Our investigation has demonstrated that the more diluted 0.6% preparation was more rapidly bactericidal than the 5% povidone-iodine formulation, most probably due to the fact that dilution from 5% to 0.6% increases the amount of free iodine. While our finding must be confirmed by in vivo clinical studies, this fact constitutes an intriguing news for what concerns the use of povidone-iodine eye drops in the ocular surface treatment before intravitreal injections as well as ophthalmic surgery.

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Povidone-iodine antisepsis before ophthalmic surgery

Anaesthesia ◽

10.1111/j.1365-2044.2006.04856.x ◽

2006 ◽

Vol 61 (11) ◽

pp. 1128-1129 ◽

Cited By ~ 1

Author(s):

Y. K. Ghosh ◽

H. Ahluwalia ◽

J. Beamer

Keyword(s):

Povidone Iodine ◽

Ophthalmic Surgery

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A comparative evaluation of intravenous dexmedetomidine and oral clonidine in attenuating the rise in intra ocular pressure

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20174389 ◽

2017 ◽

Vol 6 (10) ◽

pp. 2528 ◽

Cited By ~ 1

Author(s):

Yadhuraj M. K. ◽

Somasekharam P. ◽

Vinay D. M. ◽

Akhil Rao U. K.

Keyword(s):

Comparative Evaluation ◽

Sterile Water ◽

Ophthalmic Surgery ◽

Oral Clonidine ◽

Intra Ocular Pressure ◽

Induction Group ◽

Ocular Pressure ◽

Perforating Injury ◽

Group D ◽

Better Than

Background: Administration of Suxamethonium, laryngoscopy and intubation is associated with rise in intraocular pressure (IOP). The need to attenuate rise in IOP is of utmost importance, especially in patients with perforating injury of the eyeball. The present study was undertaken to compare the effectiveness of intravenous Dexmedetomidine 0.4μg/kg and oral Clonidine 3μg/kg in attenuating the rise in IOP following administration of suxamethonium, laryngoscopy and intubation.Methods: 150 patients of ASA I or II, aged between 18-60 years, who were posted for elective non-ophthalmic surgery requiring general anaesthesia were included in this study. Patients were randomly divided into 3 groups with 50 patients in each group. Group-D: Received 0.4μg/kg IV dexmed in 10ml sterile water, over 10 min before induction. Group-C: Received 3μg/kg oral clonidine two hours prior to surgery. Group-S: Control group.Results: IOP, MAP, and HR were recorded at baseline, before induction, after induction, 1 min, 3 min and 5 min after administration of suxamethonium. Although Suxamethonium laryngoscopy and intubation increased IOP in all the 3 groups there was significant reduced rise in IOP noted in dexmed group and clonidine group compared to study group (p= <0.001). Furthermore, patients in dexmed group had lesser rise in IOP compared to clonidine group (p= <0.001).Conclusions: We concluded that both intravenous dexmedetomidine 0.4μg/kg and oral clonidine 3μg/kg, significantly attenuated the rise in IOP associated with administration of suxamethonium, laryngoscopy and intubation. However intravenous dexmedetomidine proved better than oral clonidine in attenuating the rise in IOP.

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