Population-Balance Study of Protein Crystal Growth from Solution using a Hyperbolic Rate Law

2021 ◽  
pp. 126417
Author(s):  
Douglas A. Barlow ◽  
Emilie Lavoie-Ingram ◽  
Jahan Bayat
Keyword(s):  
Crystal Growth ◽  
Population Balance ◽  
Protein Crystal ◽  
Balance Study ◽  
Rate Law ◽  
Growth From Solution ◽  
Protein Crystal Growth

scholarly journals Size Evolution and Composition of the Intermediate Phase During Nonclassical Protein Crystal Growth from Solution

2020 ◽  
Author(s):  
Douglas Barlow ◽  
Jan Gregus
Keyword(s):  
Crystal Growth ◽  
Intermediate Phase ◽  
Protein Crystal ◽  
Low Density ◽  
Order Kinetic ◽  
X Ray Diffraction ◽  
Growth From Solution ◽  
Protein Crystal Growth ◽  
Nucleation Phase ◽  
Two Phases

<div>We propose here that the intermediate nucleation phase identified in a certain case</div><div>of protein crystal growth actually consists of two distinct parts; a low density and</div><div>higher density phase. A theory for crystal growth is utilized to study the formation</div><div>and growth of each phase. Within the framework of this theory the low density phase</div><div>is shown to obey a forth order kinetic law while the high density phase is zeroth order.</div><div>The combination of these two phases is shown to be a good match for X-ray diffraction </div><div>data which is indicative of its presence. The crystal growth rate is then given</div><div>in terms of the kinetic behavior of the intermediate nucleation phase. From this, the</div><div>crystal radius is estimated and shown to compare favorably with reported size data.</div><div>A method is proposed for determining the conditions that lead to protein crystals of</div><div>largest possible size.</div>

scholarly journals Size Evolution and Composition of the Intermediate Phase During Nonclassical Protein Crystal Growth from Solution

2020 ◽  
Author(s):  
Douglas Barlow ◽  
Jan Gregus
Keyword(s):  
Crystal Growth ◽  
Intermediate Phase ◽  
Protein Crystal ◽  
Low Density ◽  
Order Kinetic ◽  
X Ray Diffraction ◽  
Growth From Solution ◽  
Protein Crystal Growth ◽  
Nucleation Phase ◽  
Two Phases

<div>We propose here that the intermediate nucleation phase identified in a certain case</div><div>of protein crystal growth actually consists of two distinct parts; a low density and</div><div>higher density phase. A theory for crystal growth is utilized to study the formation</div><div>and growth of each phase. Within the framework of this theory the low density phase</div><div>is shown to obey a forth order kinetic law while the high density phase is zeroth order.</div><div>The combination of these two phases is shown to be a good match for X-ray diffraction </div><div>data which is indicative of its presence. The crystal growth rate is then given</div><div>in terms of the kinetic behavior of the intermediate nucleation phase. From this, the</div><div>crystal radius is estimated and shown to compare favorably with reported size data.</div><div>A method is proposed for determining the conditions that lead to protein crystals of</div><div>largest possible size.</div>

Microgravity protein crystal growth

1991 ◽  
Author(s):  
CHARLES BUGG ◽  
LAWRENCE DELUCAS
Keyword(s):  
Crystal Growth ◽  
Protein Crystal ◽  
Protein Crystal Growth

Simulation of fluid flow during protein crystal growth in magnetic fields

2011 ◽  
Vol 110 (4) ◽  
pp. 043903 ◽  
Author(s):  
H. Okada ◽  
N. Hirota ◽  
S. Matsumoto ◽  
H. Wada
Keyword(s):  
Fluid Flow ◽  
Crystal Growth ◽  
Magnetic Fields ◽  
Protein Crystal ◽  
Protein Crystal Growth

Effects of Convective Solute and Impurity Transport in Protein Crystal Growth

1998 ◽  
Vol 102 (26) ◽  
pp. 5208-5216 ◽  
Author(s):  
Peter G. Vekilov ◽  
Bill R. Thomas ◽  
Franz Rosenberger
Keyword(s):  
Crystal Growth ◽  
Protein Crystal ◽  
Impurity Transport ◽  
Protein Crystal Growth
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