Impact of local injection of brain-derived neurotrophic factor–expressing mesenchymal stromal cells (MSCs) combined with intravenous MSC delivery in a canine model of chronic spinal cord injury

Cytotherapy ◽  
2017 ◽  
Vol 19 (1) ◽  
pp. 75-87 ◽  
Author(s):  
Seung Hoon Lee ◽  
Yongsun Kim ◽  
Daeun Rhew ◽  
Ahyoung Kim ◽  
Kwang Rae Jo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Canine Model ◽  
Local Injection ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

Effect of the combination of mesenchymal stromal cells and chondroitinase ABC on chronic spinal cord injury

Cytotherapy ◽  
2015 ◽  
Vol 17 (10) ◽  
pp. 1374-1383 ◽  
Author(s):  
Seung Hoon Lee ◽  
Yongsun Kim ◽  
Daeun Rhew ◽  
Minyong Kuk ◽  
Mijung Kim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Chronic Spinal Cord Injury ◽  
Chondroitinase Abc ◽  
Cord Injury

scholarly journals Human Brain–Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury

Dose-Response ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 155932582091093
Author(s):  
YongLei Li ◽  
Hongchen Wang ◽  
Xiaofang Ding ◽  
Jiancheng Shen ◽  
Haitao Zhou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Factor Gene ◽  
Cord Injury ◽  
Marrow Mesenchymal Stem Cells

Objective: To assess the effect as well as mechanism of bone marrow mesenchymal stem cells (BMSCs) modified by the human brain–derived neurotrophic factor gene combined with erythropoietin (EPO) in the treatment of acute spinal cord injury (SCI) in rats. Methods: The Brain-derived neurotrophic factor (BDNF) gene was transected by a virus vector. Rats with SCI were randomly split into following groups: The normal saline (NS) group, the EPO group, The Basso, Beattie, and Bresnahan scores, messenger RNA BDNF expression, and apoptosis rates were compared between the 4 groups at 1, 3, 7, 14, and 21 days after SCI. Results: At 7, 14, and 21 days after operation, the expression of the BDNF gene in the other 3 groups was higher than that of the NS group, and the difference was statistically significant ( P < .05). The apoptosis rate in the combined group was less than that of NS, EPO, and BDNF/BMSC groups, and the differences were statistically significant ( P < .05). Conclusion: Brain-derived neurotrophic factor gene-modified BMSC transplantation combined with EPO can promote the repair of nerve function after SCI in rats.

Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury

Cytotherapy ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. 434-448 ◽  
Author(s):  
Zhilai Zhou ◽  
Yinhai Chen ◽  
Hui Zhang ◽  
Shaoxiong Min ◽  
Bo Yu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cord Injury
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