scholarly journals Association of vitiligo with anemia, vitamin B12 deficiency, diabetes mellitus, and thyroid dysfunction in Saudi Arab patients: A case control study

2017 ◽  
Vol 21 (2) ◽  
pp. 72-76
Author(s):  
Thamer Mubki ◽  
Ahmed Alissa ◽  
Sanjeev Mulekar ◽  
Salma Albargawi ◽  
Mohammed Youssef ◽  
...  
Author(s):  
Gonca Bektaş ◽  
Melike Ersoy Olbak ◽  
Emine Ergül Sarı ◽  
Soner Erdin ◽  
Yüksel Gülen Çiçek

2018 ◽  
Vol 37 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Khalid M. Al-Batayneh ◽  
Mazhar Salim Al Zoubi ◽  
Murad Shehab ◽  
Bahaa Al-Trad ◽  
Khaldon Bodoor ◽  
...  

SummaryBackground:Vitamin B12 (cobalamin) deficiency is a prevalent worldwide health concern. Several factors are associated with vitamin B12 deficiency including lifestyle, genetic predisposition, and malfunctions in the absorption and transport of vitamin B12. In the current case-control study, we aimed at investigating the association between MTHFR polymorphisms and vitamin B12 deficiency in a Jordanian population.Methods:Two polymorphic sites of the MTHFR gene (c.677C>T, rs1801133 and c.1286A>C, rs1801131) were analyzed using RFLP and DNA sequencing in a group of vitamin B12 deficient individuals (45 males and 55 females). As a control, 100 matching individuals (age and sex) with vitamin B12 levels > 200 ng/mL were also recruited for this study.Results:The MTHFR c.677C>T variant was significantly associated with vitamin B12 deficiency in individuals from northern Jordan. The frequency of the homozygous MTHFR c.677C>T genotype was significantly higher in B12 deficient individuals in comparison with the control group (X2= 8.397, p = 0.0150). The T allele frequency showed significant association with vitamin B12 deficiency in the study population (OR= 1.684, 95% CI: 1.116 to 2.542, p = 0.017). On the other hand, the MTHFR c.1286A>C variant did not show significant association with vitamin B12 deficiency in the selected population.Conclusions:Our results showed a significant association between homozygous MTHFR c.677C>T variant and T allele frequencies and vitamin B12 deficiency in the Jordanian population.


2016 ◽  
Vol 5 (72) ◽  
pp. 5253-5256
Author(s):  
Subbaiah Vasan Chandrakumar ◽  
Ponnusamy Thiyagarajan ◽  
Amit Jain K ◽  
Thangaraj Murugalakshmi ◽  
Srinivasan Muralikrishnan

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