Simple bicarbonate buffer system for dissolution testing: Floating lid method and its application to colonic drug delivery system

Glutaraldehyde cross-linked chitosan coated-alginate microspheres were prepared to improve site specificity in colonic drug delivery system. Microspheres were characterized by microscopic image analysis, DSC and IR to study the formation of microspheres structure as well as the chemical interactions between drug and polymer. Microscope observation showed good spherical and homogeneous of microspheres. The glutaraldehyde cross-linked microspheres could produce Schiff base reaction and decrease chitosan hydrogen bonding interaction with mucous membrane. The drug loading of chitosan coated-alginate microspheres reached 43% and in vitro release properties of microspheres without cecal contents reached 20.96% after 12 h. The release profiles indicated that microsphere has a satisfactory sustained release behavior. Glutaraldehyde cross-linked chitosan coated-alginate microspheres have a great potential use in drug delivery system.

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A novel pH- and time-based multi-unit potential colonic drug delivery system. II. Optimization of multiple response variables

International Journal of Pharmaceutics ◽

10.1016/s0378-5173(00)00650-5 ◽

2001 ◽

Vol 213 (1-2) ◽

pp. 93-102 ◽

Cited By ~ 49

Author(s):

Vishal K Gupta ◽

Manfred W Assmus ◽

Thomas E Beckert ◽

James C Price

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Multiple Response ◽

Colonic Drug Delivery ◽

Response Variables

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Formulation development and evaluation of colonic drug delivery system of budesonide microspheres by using spray drying technique

Journal of Pharmacy Research ◽

10.1016/j.jopr.2013.04.016 ◽

2013 ◽

Vol 6 (4) ◽

pp. 456-461

Author(s):

Raosaheb S. Shendge ◽

Fahim J. Sayyad

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Spray Drying ◽

Delivery System ◽

Formulation Development ◽

Colonic Drug Delivery

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Potential application of Colonic drug delivery system in prevention and treatment of Colorectal Cancer

10.53049/tjopam.2021.v001i03.011 ◽

2021 ◽

Vol 001 (03) ◽

Author(s):

Mudassir Ansari ◽

Kavita Singh

Keyword(s):

Colorectal Cancer ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Drug Distribution ◽

Gi Tract ◽

Colonic Drug Delivery ◽

Targeted Drug ◽

Targeted Drug Delivery System

Colorectal cancer (CRC) is the second leading cause of cancer related deaths in USA. The current regimen used to treat colorectal cancer has many side effects and have higher drug distribution in other tissues. Physical activity and diet play major role in prevention of Colon cancer which is briefly discussed in this paper. Colon targeted drug delivery system (CoDDS) is found to be a promising approach to target the drug specifically to colon. This review provides the description of various colon targeted approaches that can be used to treat CRC. Factors to be consider while designing CoDDS include pH of GIT, Transit time of GI tract and Microbiota of colon. This review will discuss the staging and standard treatments modalities for CRC.

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