Targeted Drug Delivery System
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2021 ◽  
Vol 28 (3) ◽  
pp. 359-359
Author(s):  
Hongfei Liu ◽  
Jie Zhu ◽  
Pengyue Bao ◽  
Yueping Ding ◽  
Jiapeng Wang ◽  
...  

The authors are regretful for submitting and approving the publication of incorrect Figure 4 in this article. Below is the corrected version along with the revised caption. The electronic version of the article has already been corrected.


2021 ◽  
Author(s):  
Dan Wang ◽  
Tianshou Cao ◽  
Wanyu Li ◽  
Li Li ◽  
Qunfa Huang ◽  
...  

Abstract Small cell lung cancer (SCLC) accounts for 13% ~ 15% of lung cancer. It is a subtype with high malignancy and poor prognosis. Almost all patients with SCLC will inevitably have drug resistance and tumor recurrence, which has become an urgent problem in the treatment of SCLC. Nuclear-targeted drug delivery system, which enables intra-nuclear release of anticancer drugs, is expected to address this challenge. In this study, based on transactivator of transcription (TAT)’s active transport property to the nucleus, we developed a high-efficiency nucleus-targeted co-delivery vector that delivers genes and drugs directly into the nucleus of A549 cells. The system is based on a poly-(N-ε-carbobenzyloxy-L-lysine) (PZLL) and dendritic polyamidoamine (PAMAM) block copolymer (PZLL-D3) with TAT modified on the surface of carrier. In vitro studies showed that DOX and p53 could can be effectively transported to the nucleus and kill the cancer cells. Thus, such deliver system would bypass the drug resistance and tumor recurrence problem.


2021 ◽  
pp. X
Author(s):  
Ying WANG ◽  
Li SU ◽  
Bing LI ◽  
Ningning JIN ◽  
Riji LU ◽  
...  

A carboxyl-terminated fullerene pyrrolidine derivative was synthesized by 1, 3-dipolar cycloaddition of imine ylide (FP-COOH). UV-Vis, FT-IR and MALDI-TOF respectively verified the effective synthesis of compounds. The compound (FP-COOH) was used as an intermediate, and then the hydrothermal chemical bonding method was used to load ferric oxide on the compound (FP-COOH). Its purpose was to form a magnetic targeting carrier system (FP-IONP-COOH). Then use the non-covalent method to combine FP-IONP-COOH with doxorubicin. The ultimate goal was to improve the side effects of doxorubicin. The solubility experiments showed that both FP-IONP-COOH and FP-IONP-COOH/DOX had good water solubility. The investigation of magnetism showed that FP-IONP-COOH has good magnetism. Finally, in vitro release experiments further verified the targeting of FP-IONP-COOH/DOX. The cumulative release of DOX at 48 h could be as high as 82 %, whereas the accumulated release of FP-IONP-COOH/DOX at 48 h was only 48 %, and was able to continuously release for more than 120 h, demonstrating its good sustained release in vivo.


2021 ◽  
Vol 11 (2) ◽  
pp. 247-252
Author(s):  
K. Muni Raja Lakshmi ◽  
CH. Suma Shree ◽  
N. Lakshmi Priya

Targeted drug delivery system is a unique type of medication conveyance framework where the pharmacologically dynamic specialists mainly focused on its site activity and not to the non-focused on organs, tissues or cells. Nano sponges are such sort of compelling pharmaceutical transporters, which take care of issues like harmfulness and helpless bioavailability such as they can stack both hydrophilic and hydrophobic medicines. Various classifications of medications can stack into Nano sponge for focused medication conveyance. This targeted drug delivery system is one of the most encouraging methodologies in the existence of science. Nano sponges are little in size with a three-dimensional organization and nanometric depression. Nano sponges are exceptionally permeable and have the extraordinary capacity to ensure dynamic particles and offer programmable delivery. This Review article explains the overall presentation of nano sponges a grouping of nano sponge trademark highlights of nano sponges their points of interest inconveniences, and synthetic compounds utilized in their planning, arrangement of technical factors influencing on the preparation component activities and assessment boundaries with some particular applications.  Keywords: Nano sponges; Targeted drug delivery; Solubility Enhancement; controlled drug delivery.


Author(s):  
Gopavaram Sumanth ◽  
Pooja Prakash Atpadkar ◽  
Pandupalli Krishna Reddy ◽  
Gorthi Nihar

The colon is where both systemic and local conveyance of medications can occur. Local conveyance permits site treatment of inflammatory bowel disease, Crohn's illness, ulcerative colitis, and so forth in any case, treatment can be created compelling if the medications can be focused on straightforwardly into the colon, in this way diminishing the systemic adverse effects. A medication should be shielded from degradation to accomplish effective colon targeting delivery, release, and absorption in the upper bit of the gastro intestinal tract (GIT) and afterward to be certain controlled delivery in the proximal colon. Pressure controlled colonic conveyance capsules, CODESTM, and the osmotic controlled medication conveyance are the more up to date advances in particular which are having in vivo site explicitness, and attainability of manufacturing process. To beat previous technique's restrictions new frameworks and advancements have been created for colon targeting. This review gives data about CDDS, new advances, limitations.


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