Relation of serum heart type fatty acid binding protein to left ventricular diastolic dysfunction in patients with type 2 diabetes and early diabetic kidney disease

Abstract Background The relationship between adipocyte fatty acid-binding protein (AFABP) and cardiac remodelling has been reported in cross-sectional studies, although with conflicting results. Type 2 diabetes mellitus (T2DM) is associated with left ventricular (LV) hypertrophy and diastolic dysfunction, as well as elevated circulating AFABP levels. Here we investigated prospectively the association between AFABP with the longitudinal changes of cardiac remodelling and diastolic dysfunction in T2DM. Methods Circulating AFABP levels were measured in 176 T2DM patients without cardiovascular diseases (CVD) at baseline. All participants received detailed transthoracic echocardiography both at baseline and after 1 year. Multivariable linear and Cox regression analyses were used to evaluate the associations of circulating AFABP levels with changes in echocardiography parameters and incident major adverse cardiovascular events (MACE), respectively. Results The median duration between baseline and follow-up echocardiography assessments was 28 months. Higher sex-specific AFABP quartiles at baseline were associated with increase in LV mass and worsening of average E/e′ (all P < 0.01). Multivariable linear regression demonstrated that AFABP in the highest quartile was independently associated with both increase in LV mass (β = 0.89, P < 0.01) and worsening of average E/e′ (β = 0.57, P < 0.05). Moreover, multivariable Cox regression analysis showed that elevated baseline circulating AFABP level independently predicted incident MACE (HR 2.65, 95% CI 1.16–6.05, P < 0.05) after adjustments for age, sex, body mass index, glycated haemoglobin, hypertension, dyslipidemia and presence of chronic kidney disease. Conclusion Circulating AFABP level at baseline predicted the development of LV hypertrophy, diastolic dysfunction and MACE in T2DM patients without CVD.

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Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects

Nutrition and Diabetes ◽

10.1038/nutd.2014.3 ◽

2014 ◽

Vol 4 (2) ◽

pp. e106-e106 ◽

Cited By ~ 23

Author(s):

A Baessler ◽

V Lamounier-Zepter ◽

S Fenk ◽

C Strack ◽

C Lahmann ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Morbidly Obese ◽

Fatty Acid Binding ◽

Protein Levels ◽

Acid Binding Protein ◽

Ventricular Diastolic Dysfunction ◽

Obese Subjects

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Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population

Cardiovascular Diabetology ◽

10.1186/s12933-014-0126-7 ◽

2014 ◽

Vol 13 (1) ◽

Cited By ~ 47

Author(s):

Takahiro Fuseya ◽

Masato Furuhashi ◽

Satoshi Yuda ◽

Atsuko Muranaka ◽

Mina Kawamukai ◽

...

Keyword(s):

Fatty Acid ◽

General Population ◽

Diastolic Dysfunction ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Ventricular Diastolic Dysfunction

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Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes

Clinical Chemistry ◽

10.1373/clinchem.2018.289157 ◽

2018 ◽

Vol 64 (10) ◽

pp. 1496-1504 ◽

Cited By ~ 5

Author(s):

Chi Ho Lee ◽

Chloe Y Y Cheung ◽

Yu Cho Woo ◽

David T W Lui ◽

Michele M A Yuen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Independent Predictor ◽

Fatty Acid Binding ◽

Men And Women ◽

Acid Binding Protein ◽

All Cause Mortality

AbstractINTRODUCTIONRaised circulating adipocyte fatty acid–binding protein (AFABP) concentrations are associated with various adverse health conditions. However, their relationship with mortality remains to be defined, especially in view of the sexual dimorphism of circulating AFABP concentrations. Here we investigated prospectively whether serum AFABP concentrations predict multiple mortality outcomes in men and women alike, using a large clinic-based cohort of individuals with type 2 diabetes, a condition with raised AFABP concentrations.METHODSBaseline serum AFABP concentrations were measured in 5305 research participants with a monoclonal antibody-based sandwich immunoassay. The role of circulating AFABP concentrations in predicting mortality outcomes was evaluated by multivariable Cox regression analysis.RESULTSAmong the 5305 participants (59% men) in this study, over a median follow-up of 5 years, there were 512 deaths (19.3 deaths per 1000 person-years). Circulating AFABP concentrations, with higher levels in women at baseline, predicted all-cause mortality (P < 0.001), cardiovascular mortality (P = 0.037), and infection-related deaths (P < 0.002) among all participants. In sex-specific analyses, circulating AFABP concentration was an independent predictor of all-cause mortality in both men and women and a predictor of cancer-related deaths and infection-related deaths in men only. Furthermore, the addition of serum AFABP concentrations improved the time-dependent c statistics in predicting all-cause mortality in participants with type 2 diabetes (P = 0.008).CONCLUSIONSCirculating AFABP concentration was an independent predictor of various mortality outcomes in type 2 diabetes over and above known risk factors of reduced survival in men and women. The role of AFABP as a prognostic biomarker and therapeutic target warrants further investigation.

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