Three-way junction DNA based electrochemical biosensor for microRNAs detection with distinguishable locked nucleic acid recognition and redox cycling signal amplification

We report a novel electrochemical biosensor for the ultrasensitive Hg2+ detection via a signal amplification strategy. This strategy could be easily modified and extended to detect other hazardous heavy metals and nucleic acid.

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Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification

Nature Protocols ◽

10.1038/nprot.2007.313 ◽

2007 ◽

Vol 2 (10) ◽

pp. 2520-2528 ◽

Cited By ~ 168

Author(s):

Asli N Silahtaroglu ◽

Dorrit Nolting ◽

Lars Dyrskjøt ◽

Eugene Berezikov ◽

Morten Møller ◽

...

Keyword(s):

In Situ Hybridization ◽

Nucleic Acid ◽

Fluorescence In Situ Hybridization ◽

Signal Amplification ◽

Locked Nucleic Acid ◽

Tyramide Signal Amplification ◽

Nucleic Acid Probes ◽

Tissue Sections ◽

Frozen Tissue

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Nucleic acid‐based electrochemical biosensor: Recent advances in probe immobilization and signal amplification strategies

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology ◽

10.1002/wnan.1765 ◽

2021 ◽

Author(s):

Krishna Thapa ◽

Wenyan Liu ◽

Risheng Wang

Keyword(s):

Nucleic Acid ◽

Signal Amplification ◽

Electrochemical Biosensor ◽

Recent Advances

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Bimetallic Pd–Pt supported graphene promoted enzymatic redox cycling for ultrasensitive electrochemical quantification of microRNA from cell lysates

The Analyst ◽

10.1039/c4an00777h ◽

2014 ◽

Vol 139 (16) ◽

pp. 3860-3865 ◽

Cited By ~ 28

Author(s):

Fang-Fang Cheng ◽

Jing-Jing Zhang ◽

Ting-Ting He ◽

Jian-Jun Shi ◽

E. S. Abdel-Halim ◽

...

Keyword(s):

Signal Amplification ◽

Electrochemical Biosensor ◽

Redox Cycling ◽

Ultrasensitive Detection ◽

Cell Lysates

A novel electrochemical biosensor with triple signal amplification for the ultrasensitive detection of miRNA was developed.

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Sensitive biosensor for p53 DNA sequence based on the photothermal effect of gold nanoparticles and the signal amplification of locked nucleic acid functionalized DNA walkers using a thermometer as readout

Talanta ◽

10.1016/j.talanta.2020.121398 ◽

2020 ◽

Vol 220 ◽

pp. 121398

Author(s):

Yingzhou Tao ◽

Weijia Wang ◽

Caili Fu ◽

Fang Luo ◽

Longhua Guo ◽

...

Keyword(s):

Gold Nanoparticles ◽

Nucleic Acid ◽

Dna Sequence ◽

Signal Amplification ◽

Locked Nucleic Acid ◽

Photothermal Effect ◽

Dna Walkers

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A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction

Biosensors and Bioelectronics ◽

10.1016/j.bios.2017.10.050 ◽

2018 ◽

Vol 102 ◽

pp. 33-40 ◽

Cited By ~ 69

Author(s):

Jing Zhang ◽

Liang-Liang Wang ◽

Mei-Feng Hou ◽

Yao-Kun Xia ◽

Wen-Hui He ◽

...

Keyword(s):

Nucleic Acid ◽

Electrochemical Biosensor ◽

Locked Nucleic Acid ◽

Displacement Reaction ◽

Strand Displacement ◽

Dna Walkers ◽

Strand Displacement Reaction

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Faculty Opinions recommendation of Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1166571.627578 ◽

2009 ◽

Author(s):

Fritz Eckstein

Keyword(s):

Nucleic Acid ◽

Gene Silencing ◽

Antisense Oligonucleotides ◽

Locked Nucleic Acid ◽

Efficient Gene

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A novel label free long non-coding RNA electrochemical biosensor based on green l-cysteine electrodeposition and Au–Rh hollow nanospheres as tags

RSC Advances ◽

10.1039/c5ra07904g ◽

2015 ◽

Vol 5 (64) ◽

pp. 51990-51999 ◽

Cited By ~ 13

Author(s):

Fei Liu ◽

Guiming Xiang ◽

Liqun Zhang ◽

Dongneng Jiang ◽

Linlin Liu ◽

...

Keyword(s):

Carbon Nanotubes ◽

Signal Amplification ◽

Electrochemical Biosensor ◽

Single Wall Carbon Nanotubes ◽

Complex Signal ◽

Ultrasensitive Detection ◽

Label Free ◽

Hollow Nanospheres ◽

Non Coding Rna ◽

Long Non Coding Rna

lncRNA biosensor based on single-wall carbon nanotubes wrapped with Au–Rh hollow nanospheres (Au/Rh-HNP@SWCNT) complex signal amplification and an l-Cys Au nano-film provided ultrasensitive detection for the nuclear paraspeckle assembly transcript 1 (NEAT1).

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