Anti-inflammatory and analgesic properties of water–ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts

2005 ◽  
Vol 99 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Fabio F. Perazzo ◽  
Gustavo H.B. Souza ◽  
Walter Lopes ◽  
Luis G.V. Cardoso ◽  
Jose C.T. Carvalho ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Aerial Parts ◽  
Anti Inflammatory

scholarly journals An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

2020 ◽  
Vol 7 (01) ◽  
pp. e17-e25 ◽  
Author(s):  
Paula Pereira de Paiva ◽  
Fabiana Regina Nonato ◽  
Ana Lúcia Tasca Gois Ruiz ◽  
Ilza Maria de Oliveira Sousa ◽  
Rafael Rosolen Teixeira Zafred ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Experimental Models ◽  
New Drugs ◽  
Antiproliferative Effects ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Effective Source

AbstractThe tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

scholarly journals Phytochemical and Pharmacological evaluation of hibiscus hispidissimus griff

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2063-2067
Author(s):  
Alekhya V ◽  
Ganapaty S ◽  
Deepan T
Keyword(s):  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Phytochemical Analysis ◽  
Zone Of Inhibition ◽  
E Coli ◽  
Aerial Parts ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Rat Paw Oedema

To assess phytochemical with pharmacological studies of Hibiscus hispidissimus griff belong to family malavaceae. Preliminary phytochemical analysis reveals the presence of steroids, triterpenes, saponins, steroidal saponins and phenols. Evaluation of anti-inflammatory, anti-microbial with antioxidant action were performed on aerial parts of methanolic extract of Hibiscus hispidissimus. Invitro antioxidant activity was performed by 2, 2 -diphenyl- 1- picrylhydrazyl (DPPH) assay, hydroxy radical scavenging method and superoxide radical scavenging activity.The results of invitro antioxidant study reveal that % inhibition of H. hispidissimus  was higher compared to ascorbic acid. Anti-inflammatory studies were performed using carrageenan-induced rat paw oedema animal model, for anti-inflammatory studies, the extracts were compared with standards like indomethacin, and it shows a remarkable zone of inhibition ranging from 58.97 to 71.73 respectively. The anti-bacterial and antifungal activity of plant extracts were studied for the occurrence of inhibition zones. The activity was performed by the cup plate method. Ethanolic extract of H. Hispidissimus  shows significant anti-bacterial effect against S. Aureus, B. Subtilis, P. Vulgaris and E. coli using ciprofloxacin (50µg/ml) as standard.The extracts show remarkable inhibition of zone of inhibition, and results were compared with that of standard drugs against the organism tested. In conclusion, the ethanolic extract of H. hispidissimus  shows  significant antioxidant, anti-inflammatory and anti-bacterial properties.

New Anti-inflammatory Triterpene Esters and Glycosides from Alstonia scholaris

2020 ◽  
Vol 19 (4) ◽  
pp. 370-386
Author(s):  
Nighat Sultana ◽  
Muhammad Saleem Qazi ◽  
Mustafa Kamal
Keyword(s):  
Ethanolic Extract ◽  
Two Dimensional ◽  
1H And 13C Nmr ◽  
Alstonia Scholaris ◽  
Aerial Parts ◽  
Nmr Data ◽  
Lupeol Acetate ◽  
Anti Inflammatory ◽  
Phytochemical Studies ◽  
Triterpene Esters

Background:: Phytochemical studies on the ethanolic extract of aerial parts of Alstonia scholaris lead to the isolation of two new triterpenoid of the lanostanetype, lanosta 5ene,24-ethyl-3-O-β-D-glucopyranoside (1), lanosta,5ene,24-ethyl-3-O-β-D-glucopyranosideester (2) and new ursane type triterpenoidmethylester, 12-ursene-2,3,18,19-tetrol,28 acetate (nighascholarene) (3), together with seven known triterpenes, betuline, triterpene of the lupane type, alstoprenyol (4), 3β-hydroxy-28-β-acetoxy-5-olea triterpene (5),α-amyrin acetate (6), α-amyrin (7), lupeol acetate (8), 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene (9) and ursolic acid (l0). Methodology:: The triterpenoid structures of these colorless compounds were deduced from the 1H and 13C-NMR data, and in particular from the application of two-dimensional 1H, 13C correlation experiments as well as by comparison with reported literature data. Results and Conclusion: This study deals with isolation and structural elucidation of natural new triterpenoidesters and glycosides with anti-inflammatory activity.

scholarly journals Anti-inflammatory and antioxidant activities of ethanolic extract of aerial parts of Vernonia patula (Dryand.) Merr.

2013 ◽  
Vol 3 (10) ◽  
pp. 798-805 ◽  
Author(s):  
Arpona Hira ◽  
Shubhra Kanti Dey ◽  
Md. Sariful Islam Howlader ◽  
Arif Ahmed ◽  
Hemayet Hossain ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Aerial Parts ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory Effects of Compounds from Polygonum odoratum

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Siriporn Okonogi ◽  
Kantaporn Kheawfu ◽  
Wolfgang Holzer ◽  
Frank M. Unger ◽  
Helmut Viernstein ◽  
...  
Keyword(s):  
High Performance ◽  
Ethanolic Extract ◽  
Antitumor Agent ◽  
Reversed Phase ◽  
Inflammatory Activity ◽  
Resonance Spectroscopy ◽  
Edible Plant ◽  
Aerial Parts ◽  
Isolation And Characterization ◽  
Anti Inflammatory

Polygonum odoratum is an edible plant traditionally used as an antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate the anti-inflammatory effect of P. odoratum and the isolation and characterization of its main fractions. Extracts of the aerial parts were tested for anti-inflammatory activity as indicated by a change in the cytokine secretion in lipopolysaccharide-stimulated macrophages. After separation of the extract by reversed-phase high-performance liquid chromatography, the anti-inflammatory activity of the fractions was determined. Furthermore, the two main fractions were identified by nuclear magnetic resonance spectroscopy (1H- and 13C-NMR). The ethanolic extract significantly reduced IL-6 secretion (IC50 25 μg/mL). The two main fractions (5 and 7) significantly decreased IL-6 production with an IC50 of 102 μM (5) and 77 μM (7), respectively, and were identified as scutellarein-7-glucoside (5) and quercitrin (7). Since inflammation plays a major role in various diseases with high prevalence globally, it may be of importance that P. odoratum and its main constituents scutellarein-7-glucoside and quercitrin can be used as either an alternative or complementary treatment. Additionally, both are glycosides and their activity may be enhanced tremendously by deglycosylation by the gut microbiota.

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