Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin

2016 ◽  
Vol 187 ◽  
pp. 17-27 ◽  
Author(s):  
Yaw Duah Boakye ◽  
Christian Agyare ◽  
Wonder Kofi Mensah Abotsi ◽  
Patrick George Ayande ◽  
Paul Poku Sampene Ossei
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Major Constituent ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

scholarly journals Suppression of inflammatory mediators by aqueous leaf extract of Crotalaria verrucosa: in vivo and in vitro analysis

2020 ◽  
Vol 9 (12) ◽  
pp. 1897
Author(s):  
Mohammad Mustakim Billah ◽  
Abir Huzaifa ◽  
M. Abdul Kader Khan ◽  
Nusrat Jahan Vabna ◽  
Kashfia Nawrin ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Protein Denaturation ◽  
Inflammatory Activity ◽  
Medicinal Value ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory ◽  
Vitro Analysis ◽  
In Vitro Analysis

Background: Crotalaria verrucosa is a traditional plant frequently prescribed by the tribes for its medicinal value against inflammation. The present study was designed to investigate the scientific basis for medicinal value in inflammation by in vivo and in vitro analysis.Methods: Anti-inflammatory activity of the plant’s leaf was evaluated by two in vivo methods - carrageenan induced rat paw edema and xylene induced mice ear edema. Moreover, in vitro analysis was performed through heat induced hemolysis and heat induced protein denaturation methods.Results: The inflammation produced by carrageenan and xylene were effectively suppressed by the aqueous leaf extract of C. verrucosa (CVAQ) at 600 mg/kg body weight which was comparable to the standards. In heat induced hemolysis test the extract was able to inhibit the lysis up to 70% at 500 µg/ml whereas in heat induced protein denaturation test it reduces the percentage till 69% at the same concentration.Conclusions: The findings suggested that CVAQ possess moderate to high anti-inflammatory activity when applied in low to high concentrated doses. However, the study can only conclude from this basic evaluation that the extract needs to be further investigated for identifying the potential compound which contributed to such medicinal value of the plant.

scholarly journals Anti-inflammatory Activity of the Aqueous Leaf Extract ofIxora coccinea.

2005 ◽  
Vol 43 (2) ◽  
pp. 147-152 ◽  
Author(s):  
W.D. Ratnasooriya ◽  
S.A. Deraniyagala ◽  
G. Galhena ◽  
S.S.P. Liyanage ◽  
S.D.N.K. Bathige ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata

2005 ◽  
Vol 13 (5-6) ◽  
pp. 479-484 ◽  
Author(s):  
Victor B. Owoyele ◽  
Joseph O. Adediji ◽  
Ayodele O. Soladoye
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Chromolaena Odorata ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Anti-inflammatory activity of leaf extract and fractions of Bursera simaruba (L.) Sarg (Burseraceae)

2004 ◽  
Vol 92 (1) ◽  
pp. 129-133 ◽  
Author(s):  
B. Noguera ◽  
E. Dı́az ◽  
M.V. Garcı́a ◽  
A.San Feliciano ◽  
J.L. López-Perez ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Bursera Simaruba ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Activity of Populus deltoides Leaf Extract via Modulating NF-κB and p38/JNK Pathways

2018 ◽  
Vol 19 (12) ◽  
pp. 3746 ◽  
Author(s):  
Ye Jeong ◽  
Mi-Young Lee
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Leaf Extract ◽  
Populus Deltoides ◽  
Nuclear Translocation ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Inflammatory Activity ◽  
No Production ◽  
Anti Inflammatory

Populus deltoides, known as eastern cottonwood, has been commonly used as a medicinal plant. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory activity of P. deltoides leaf extract (PLE). PLE effectively inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, but not that of cyclooxygenase-2 (COX-2) and prostaglandin E2. Proinflammatory tumor necrosis factor alpha (TNF-α) levels were also reduced by the extract. PLE inhibited the phosphorylation of nuclear factor-kappa B (NF-κB) and inhibitor of Kappa Bα (IκBα), and blunted LPS-triggered enhanced nuclear translocation of NF-κB p65. In mitogen-activated protein kinase (MAPK) signaling, PLE effectively decreased the phosphorylation of p38 and c-Jun N-terminal protein kinase (JNK), but not of extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these results suggest that anti-inflammatory activity of P. deltoides leaf extract might be driven by iNOS and NO inhibition mediated by modulation of the NF-κB and p38/JNK signaling pathways.

scholarly journals Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

2019 ◽  
Vol 10 (03) ◽  
pp. 259-271
Author(s):  
Loyce Nakalembe ◽  
Josephine N. Kasolo ◽  
Edward Nyatia ◽  
Aloysius Lubega ◽  
Godfrey S. Bbosa
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Phytolacca Dodecandra ◽  
Crude Leaf Extract ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

scholarly journals Analgesic and anti-inflammatory activity of methanolic fraction of total ethereal leaf extract of Annona senegalensis Pers. (Annonaceae)

2017 ◽  
Vol 11 (8) ◽  
pp. 120-124 ◽  
Author(s):  
Sene Madièye ◽  
S. Barboza Firmin ◽  
Sarr Abdou ◽  
Tchemy Outouen Dominique ◽  
Wele Alassane ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Anti Inflammatory
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