An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat.

2021 ◽  
pp. 114550
Author(s):  
Johané Gericke ◽  
Makhotso Lekhooa ◽  
Stephan F. Steyn ◽  
Alvaro M. Viljoen ◽  
Brian H. Harvey
Keyword(s):  
Acute Dose ◽  
Sensitive Line ◽  
Dose Ranging ◽  
Flinders Sensitive Line

scholarly journals The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus Flinders Sensitive Line rats

2021 ◽  
pp. 1-20
Author(s):  
Juandré Lambertus Bernardus Saayman ◽  
Stephanus Frederik Steyn ◽  
Christiaan Beyers Brink
Keyword(s):  
Sprague Dawley ◽  
Long Term Effects ◽  
Bdnf Level ◽  
Treatment Groups ◽  
Sd Rats ◽  
Behavioural Effects ◽  
Sensitive Line ◽  
Level Analysis ◽  
Flinders Sensitive Line

Abstract Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats. Methods: SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis one day later. Results: FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05). Conclusion: Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.

Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery

2020 ◽  
Vol 1737 ◽  
pp. 146797
Author(s):  
Vibeke Bay ◽  
Denise F. Happ ◽  
Maryam Ardalan ◽  
Alexandra Quist ◽  
Florian Oggiano ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression

2010 ◽  
Vol 34 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Olga Kotsovolou ◽  
Magnus Ingelman-Sundberg ◽  
Matti A. Lang ◽  
Marios Marselos ◽  
David H. Overstreet ◽  
...  
Keyword(s):  
Rat Model ◽  
Hepatic Drug ◽  
Sensitive Line ◽  
Flinders Sensitive Line
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