Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line “depressed” rat: Implications for the pathophysiology of depression?

2006 ◽  
Vol 84 (6) ◽  
pp. 1292-1302 ◽  
Author(s):  
H. Husum ◽  
S. Aznar ◽  
S. Høyer-Hansen ◽  
M. Hald Larsen ◽  
J.D. Mikkelsen ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Cell Survival ◽  
Dorsal Hippocampus ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals Elevated P2×7r and P2×4r transcripts levels in the Flinders Sensitive Line Rats, a genetic animal model of depression

2018 ◽  
Author(s):  
Deidiane Elisa Ribeiro ◽  
Heidi Kaastrup Müller ◽  
Betina Elfving ◽  
Samia Regiane Lourenço Joca ◽  
Gregers Wegener
Keyword(s):  
Animal Model ◽  
Stress Responses ◽  
Dorsal Hippocampus ◽  
Control Group ◽  
Protein Levels ◽  
Genetic Animal Model ◽  
Animal Model Of Depression ◽  
Sensitive Line ◽  
Stress Susceptibility ◽  
Flinders Sensitive Line

AbstractP2×7 and P2×4 receptors (P2×7R and P2×4R, respectively) are ligand-gated ion channels activated by adenosine triphosphate (ATP), which have been associated to dysfunctional processes in stress responses linked to depression, such as neurotransmitter release, cognition, sleep, energy, appetite, immune and endocrine dysfunction. Clinical studies indicate that polymorphisms in the P2×7r gene results in increased susceptibility for development of depression. Existing studies have investigated the role of P2×7R and P2×4R in animal models based on stress exposure. Therefore, the present work aimed to investigate the transcript and protein levels of these receptors in a genetic animal model of depression, the Flinders Sensitive Line (FSL) and its control group, the Flinders Resistant Line (FRL) rats. We found that FSL rats have increased transcript levels of P2×7R and P2×4R in frontal cortex (FC), ventral and dorsal hippocampus (vHip and dHip, respectively) compared to FRL rats. There were no alterations in the protein levels in the FC and dHip, but the P2×7R was lower in FSL than in FRL rats in the vHip. The results suggest that increased transcripts levels of P2×7r and P2×4r in the FSL rats may contribute to the stress-susceptibility observed in these animals.

Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression

1999 ◽  
Vol 265 (3) ◽  
pp. 191-194 ◽  
Author(s):  
Laura Caberlotto ◽  
Patricia Jimenez ◽  
David H. Overstreet ◽  
Yasmin L. Hurd ◽  
Aleksander A. Mathé ◽  
...  
Keyword(s):  
Animal Model ◽  
Neuropeptide Y ◽  
Binding Sites ◽  
Genetic Animal Model ◽  
Animal Model Of Depression ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus Flinders Sensitive Line rats

2021 ◽  
pp. 1-20
Author(s):  
Juandré Lambertus Bernardus Saayman ◽  
Stephanus Frederik Steyn ◽  
Christiaan Beyers Brink
Keyword(s):  
Sprague Dawley ◽  
Long Term Effects ◽  
Bdnf Level ◽  
Treatment Groups ◽  
Sd Rats ◽  
Behavioural Effects ◽  
Sensitive Line ◽  
Level Analysis ◽  
Flinders Sensitive Line

Abstract Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats. Methods: SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis one day later. Results: FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05). Conclusion: Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.

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