scholarly journals High Burden of Resistant Gram Negative Pathogens Causing Device-associated Healthcare Infections in a Tertiary Care Setting in Saudi Arabia, 2008-2016

2020 ◽  
Vol 23 ◽  
pp. 26-32
Author(s):  
Hanan H. Balkhy ◽  
Aiman El-Saed ◽  
Majid M. Alshamrani ◽  
Asim Alsaedi ◽  
Wafa Al Nasser ◽  
...  
2016 ◽  
Vol 2016 (2) ◽  
pp. 24 ◽  
Author(s):  
Mostafa Abolfotouh ◽  
Alanoud Al-Marzoug ◽  
Suliman Alteriqi ◽  
Abeer Al-Suwailem ◽  
Ra'ed Hijazi

2019 ◽  
Vol 40 (7) ◽  
pp. 732-736
Author(s):  
Fahad Alhumaid ◽  
Sultan Alturki ◽  
Sayaf Alshareef ◽  
Omar Alobaidan ◽  
Arwa Alhuwaymil ◽  
...  

2022 ◽  
Vol 9 (1) ◽  
pp. 15-19
Author(s):  
Ihsan Ullah ◽  
Aamir Hussain ◽  
Humera Adeeb ◽  
Mubarak Zeb

OBJECTIVES: To find out the frequency and pattern of conventional antibiotic susceptibility of gram-negative bacilli cultured from urine specimens of patients at a tertiary care setting. METHODOLOGY: This study was conducted at the Microbiology Department of Combined Military Hospital Multan from June 2016 to May 2017. The data in this retrospective descriptive study was collected from urine culture records of the Microbiology Department, CMH Multan. Only those urine specimens who revealed positive gram-negative bacilli cultures were included in the study. Drug susceptibility patterns of these isolates were recorded against routinely used antibiotics (e.g. Nitrofurantoin, Imipenem, Sulbactum-cefoperazone, Gentamicin and Ciprofloxacin) and evaluated accordingly. RESULTS: A total of 1703 urine specimens were submitted for culture and antibiotics susceptibility testing during the period of study. A total of 128 specimens showed growth of gram-negative rods. Imipenem (95% sensitivity), Sulbactam- Cefoperazone (88% sensitivity) and Nitrofurantoin (87% sensitivity) were highly effective antibiotics against the cultured gram-negative bacilli in the study. CONCLUSION: This study showed that E. coli is the commonest cause of urinary tract infection (UTIs), followed by Klebsiella and Enterobacter species among gram-negative bacilli in our set up. In-vitro efficacy of Imipenem, Sulbactam- Cefoperazone and Nitrofurantoin was found to be the highest against these gram-negative bacilli as compared to other antimicrobials. On the contrary, in-vitro efficacy of ciprofloxacin and gentamycin was found to be extremely low.


2019 ◽  
Author(s):  
Hanan Balkhy ◽  
Aiman El-Saed ◽  
Majid M. Alshamrani ◽  
Sameera Aljohani ◽  
Asim Alsaedi ◽  
...  

Abstract BACKGROUND Despite being largely preventable, surgical site infections (SSIs) is still one of the most frequent healthcare associated infections worldwide. The presence of resistant pathogens can further augment its clinical and economic impact. The objective was to estimate the prevalence and extent of resistance in SSI pathogens in a tertiary care setting in Saudi Arabia and to compare such data to US National Healthcare Safety Network (NHSN) hospitals.METHODS Targeted SSI surveillance was prospectively conducted on several surgical procedures done between 2007 and 2016 in four hospitals of Ministry of National Guard Health Affairs. Definitions and methodology of SSI and bacterial resistance were based on NHSN.RESULTS A total 492 pathogens causing 403 SSI events were included. The most frequent pathogens were Staphylococcus aureus (22.8%), Pseudomonas (20.1%), Klebsiella (12.2%), and Escherichia coli (12.2%), with marked variability between surgeries. Approximately 30.3% of Staphylococcus aureus were methicillin-resistant (MRSA), 13.0% of Enterococci were vancomycin-resistant (VRE), and 5.5% of Enterobacteriaceae were carbapenem resistant (CRE). The highest multidrug-resistant (MDR) GNPs were Acinetobacter (58.3%), Klebsiella (20.4%) and Escherichia coli (16.3%). MRSA was significantly less frequent while cephalosporin-resistant Klebsiella, MDR Klebsiella, and MDR Escherichia coli were significantly more frequent in our hospitals compared with NHSN hospitals.CONCLUSION GNPs in a tertiary care setting in Saudi Arabia are responsible for approximately 60% of SSI with more resistant patterns than Western countries. This information may be critical to secure resources and ensure support of caregivers and healthcare leaders in implementing antimicrobial stewardship programs and evidence-based SSI preventive practices.KEYWORDS Antimicrobial resistance, multidrug resistance, surgical site infections, surveillance, pathogens, hospital, Saudi Arabia


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