scholarly journals HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral treatment in KwaZulu-Natal Province, South Africa

2021 ◽  
Author(s):  
Benjamin Chimukangara ◽  
Richard J Lessells ◽  
Benn Sartorius ◽  
Lilishia Gounder ◽  
Sontaga Manyana ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Protease Inhibitor ◽  
Antiretroviral Treatment ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa

2017 ◽  
Vol 72 (11) ◽  
pp. 3141-3148 ◽  
Author(s):  
Gillian M Hunt ◽  
E. Kainne Dokubo ◽  
Simbarashe Takuva ◽  
Tulio de Oliveira ◽  
Johanna Ledwaba ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Primary Healthcare ◽  
Virological Suppression ◽  
Healthcare Facilities ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Carole L. Wallis ◽  
John W. Mellors ◽  
Willem D. F. Venter ◽  
Ian Sanne ◽  
Wendy Stevens
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Protease Inhibitor ◽  
Virologic Failure ◽  
Second Line ◽  
Resistance Mutations ◽  
Subtype C ◽  
Resistance Patterns ◽  
Main Barrier ◽  
Hiv 1

Limited data exist on HIV-1 drug resistance patterns in South Africa following second-line protease-inhibitor containing regimen failure. This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lopinavir/ritonavir. Ninety six percent of patients (n=72) were infected with HIV-1 subtype C, two patients were infected with HIV-1 subtype D and one with HIV-1 subtype A1. Thirty nine percent (n=29) of patients had no resistance mutations in protease or reverse transcriptase suggesting that medication non-adherence was a major factor contributing to failure. Major lopinavir resistance mutations were infrequent (5 of 75; 7%), indicating that drug resistance is not the main barrier to future viral suppression.

scholarly journals Increasing HIV-1 Drug Resistance Between 2010 and 2012 in Adults Participating in Population-Based HIV Surveillance in Rural KwaZulu-Natal, South Africa

2016 ◽  
Vol 32 (8) ◽  
pp. 763-769 ◽  
Author(s):  
Justen Manasa ◽  
Siva Danaviah ◽  
Richard Lessells ◽  
Muna Elshareef ◽  
Frank Tanser ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Population Based ◽  
Hiv Surveillance ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Viremia and drug resistance among HIV-1 patients on antiretroviral treatment: a cross-sectional study in Soweto, South Africa

AIDS ◽  
2010 ◽  
Vol 24 (11) ◽  
pp. 1679-1687 ◽  
Author(s):  
Ziad El-Khatib ◽  
Anna Mia Ekstrom ◽  
Johanna Ledwaba ◽  
Lerato Mohapi ◽  
Fatima Laher ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Antiretroviral Treatment ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hiv 1

scholarly journals Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa

2017 ◽  
Vol 72 (11) ◽  
pp. 3222-3222
Author(s):  
Gillian M Hunt ◽  
E Kainne Dokubo ◽  
Simbarashe Takuva ◽  
Tulio de Oliveira ◽  
Johanna Ledwaba ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Primary Healthcare ◽  
Virological Suppression ◽  
Healthcare Facilities ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Valentine Budambula ◽  
Francis O. Musumba ◽  
Mark K. Webale ◽  
Titus M. Kahiga ◽  
Francisca Ongecha-Owuor ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Protease Inhibitor ◽  
Injection Drug Users ◽  
Drug Users ◽  
Antiretroviral Treatment ◽  
Injection Drug ◽  
Treatment Naïve ◽  
Inhibitor Drug ◽  
Hiv 1

scholarly journals Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e59787 ◽  
Author(s):  
Urvi M. Parikh ◽  
Photini Kiepiela ◽  
Shayhana Ganesh ◽  
Kailazarid Gomez ◽  
Stephanie Horn ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Hiv Prevention ◽  
Kwazulu Natal ◽  
Prevention Trials ◽  
Hiv 1

scholarly journals Prevalence of HIV‐1 Drug Resistance after Failure of a First Highly Active Antiretroviral Therapy Regimen in KwaZulu Natal, South Africa

2008 ◽  
Vol 46 (10) ◽  
pp. 1589-1597 ◽  
Author(s):  
Vincent C. Marconi ◽  
Henry Sunpath ◽  
Zhigang Lu ◽  
Michelle Gordon ◽  
Kofi Koranteng‐Apeagyei ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Therapy Regimen ◽  
Highly Active ◽  
Kwazulu Natal ◽  
Hiv 1
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