A multicenter study of biological effects assessment of pharmacy workers occupationally exposed to antineoplastic drugs in Pharmacy Intravenous Admixture Services

2016 ◽  
Vol 315 ◽  
pp. 86-92 ◽  
Author(s):  
Jingjing Zhang ◽  
Jianan Bao ◽  
Renying Wang ◽  
Zhou Geng ◽  
Yao Chen ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Biological Effects ◽  
Antineoplastic Drugs ◽  
Occupationally Exposed ◽  
Effects Assessment

GM-009 Multicenter study of environmental 5-FU contamination during normal mixing of antineoplastic drugs

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A115.2-A115
Author(s):  
Y Sano ◽  
T Morita Ogawa ◽  
Y Hayashi ◽  
S Itoi ◽  
N Yokote ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Antineoplastic Drugs

Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations

2002 ◽  
Vol 21 (3) ◽  
pp. 129-135 ◽  
Author(s):  
S Burgaz ◽  
B Karahalil ◽  
Z Canli ◽  
F Terzioglu ◽  
G Ançel ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Population Level ◽  
Fold Increase ◽  
Mean Value ◽  
Antineoplastic Drugs ◽  
Genetic Damage ◽  
Occupationally Exposed ◽  
The Mean ◽  
Excretion Rates ◽  
Drug Handling

To estimate the genotoxic risk of occupational exposure to antineoplastic drugs, chromosomal aberration (CAs) frequencies in peripheral lymphocytes were determined for 20 nurses handling antineoplastics and 18 referents matched for age and sex. Urinary cyclophosphamide (CP) excretion rates, which are used as a marker for drug handling, were also measured on these nurses. We have observed significant frequencies of CAs (about 2.5-fold increase) including chromatid breaks, gaps, and acentric fragments for nurses handling antineoplastics as compared to control subjects (p<0.05, p<0.01, excluding and including gaps, respectively). The mean value of CP excretion rate for 12 nurses was 1.63 μg/24 h, suggesting that when the nurses handled CP (and other antineoplastic drugs) this particular compound was absorbed. Our study has shown that increased genetic damage was evident in nurses, at population level, due to occupational exposure to antineoplastics. Until the effects of handling antineoplastics from low-level exposure are known, it will be important to keep the exposure to a minimum.

Efforts to Ensure Safety of Hospital Pharmacy Personnel Occupationally Exposed to Antineoplastic Drugs During a Preparation Task

2007 ◽  
Vol 42 (3) ◽  
pp. 209-218 ◽  
Author(s):  
Kenji Ikeda ◽  
Yuriko Yagi ◽  
Manabu Takegami ◽  
Yuquan Lu ◽  
Kanehisa Morimoto ◽  
...  
Keyword(s):  
Hospital Pharmacy ◽  
Antineoplastic Drugs ◽  
Occupationally Exposed

scholarly journals Assessment of Genotoxic Damage in Nurses Occupationally Exposed to Anaesthetic Gases or Antineoplastic Drugs by the Comet Assay

2009 ◽  
Vol 51 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Seval Izdes ◽  
Semra Sardas ◽  
Ela Kadioglu ◽  
Cetin Kaymak ◽  
Eren Ozcagli
Keyword(s):  
Comet Assay ◽  
Antineoplastic Drugs ◽  
Genotoxic Damage ◽  
Anaesthetic Gases ◽  
Occupationally Exposed

Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach

2014 ◽  
Vol 88 (6) ◽  
pp. 683-695 ◽  
Author(s):  
Massimo Moretti ◽  
Maria Giuseppa Grollino ◽  
Sofia Pavanello ◽  
Roberta Bonfiglioli ◽  
Milena Villarini ◽  
...  
Keyword(s):  
Chromosome Aberrations ◽  
Antineoplastic Drugs ◽  
Occupationally Exposed ◽  
Multicentric Approach
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