Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach

2014 ◽  
Vol 88 (6) ◽  
pp. 683-695 ◽  
Author(s):  
Massimo Moretti ◽  
Maria Giuseppa Grollino ◽  
Sofia Pavanello ◽  
Roberta Bonfiglioli ◽  
Milena Villarini ◽  
...  
Keyword(s):  
Chromosome Aberrations ◽  
Antineoplastic Drugs ◽  
Occupationally Exposed ◽  
Multicentric Approach

scholarly journals mFISH analysis of chromosome aberrations in workers occupationally exposed to mixed radiation

2014 ◽  
Vol 53 (2) ◽  
pp. 347-354 ◽  
Author(s):  
Natalia V. Sotnik ◽  
Sergey V. Osovets ◽  
Harry Scherthan ◽  
Tamara V. Azizova
Keyword(s):  
Chromosome Aberrations ◽  
Occupationally Exposed

Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations

2002 ◽  
Vol 21 (3) ◽  
pp. 129-135 ◽  
Author(s):  
S Burgaz ◽  
B Karahalil ◽  
Z Canli ◽  
F Terzioglu ◽  
G Ançel ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Population Level ◽  
Fold Increase ◽  
Mean Value ◽  
Antineoplastic Drugs ◽  
Genetic Damage ◽  
Occupationally Exposed ◽  
The Mean ◽  
Excretion Rates ◽  
Drug Handling

To estimate the genotoxic risk of occupational exposure to antineoplastic drugs, chromosomal aberration (CAs) frequencies in peripheral lymphocytes were determined for 20 nurses handling antineoplastics and 18 referents matched for age and sex. Urinary cyclophosphamide (CP) excretion rates, which are used as a marker for drug handling, were also measured on these nurses. We have observed significant frequencies of CAs (about 2.5-fold increase) including chromatid breaks, gaps, and acentric fragments for nurses handling antineoplastics as compared to control subjects (p<0.05, p<0.01, excluding and including gaps, respectively). The mean value of CP excretion rate for 12 nurses was 1.63 μg/24 h, suggesting that when the nurses handled CP (and other antineoplastic drugs) this particular compound was absorbed. Our study has shown that increased genetic damage was evident in nurses, at population level, due to occupational exposure to antineoplastics. Until the effects of handling antineoplastics from low-level exposure are known, it will be important to keep the exposure to a minimum.

Efforts to Ensure Safety of Hospital Pharmacy Personnel Occupationally Exposed to Antineoplastic Drugs During a Preparation Task

2007 ◽  
Vol 42 (3) ◽  
pp. 209-218 ◽  
Author(s):  
Kenji Ikeda ◽  
Yuriko Yagi ◽  
Manabu Takegami ◽  
Yuquan Lu ◽  
Kanehisa Morimoto ◽  
...  
Keyword(s):  
Hospital Pharmacy ◽  
Antineoplastic Drugs ◽  
Occupationally Exposed

scholarly journals Assessment of Genotoxic Damage in Nurses Occupationally Exposed to Anaesthetic Gases or Antineoplastic Drugs by the Comet Assay

2009 ◽  
Vol 51 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Seval Izdes ◽  
Semra Sardas ◽  
Ela Kadioglu ◽  
Cetin Kaymak ◽  
Eren Ozcagli
Keyword(s):  
Comet Assay ◽  
Antineoplastic Drugs ◽  
Genotoxic Damage ◽  
Anaesthetic Gases ◽  
Occupationally Exposed

scholarly journals Genetic and immune-toxicologic studies on abnormal thyroid functions in hospital employees exposed to cytostatic drugs

2015 ◽  
Vol 156 (2) ◽  
pp. 60-66
Author(s):  
Anna Tompa ◽  
Mátyás Jakab ◽  
Anna Biró ◽  
Jenő Major
Keyword(s):  
T Cells ◽  
B Cells ◽  
Chromosome Aberrations ◽  
Cytotoxic T Cells ◽  
Reactive Oxygen ◽  
Neutrophil Granulocytes ◽  
Pathophysiological Mechanism ◽  
Cytostatic Drugs ◽  
Oxygen Intermediates ◽  
Occupationally Exposed

Introduction: Environmental exposure to harmful chemicals may produce severe consequences. Aim: The aim of the authors was to perform geno- and immune-toxicological monitoring in female employees occupationally exposed to cytostatic agents in hospitals and compare the findings to those obtained from controls. Method: Altogether 642 women working in hospital who were occupationally exposed to cytostatic drugs and 262 control women participated in the study. Frequency of chromosome aberrations, immune phenotype and activation of lymphocytes, and the production of reactive oxygen-species in neutrophil granulocytes were determined. Results: Markedly higher number (n=39) of thyroid alterations was observed among exposed subjects as compared to controls (n=3). In persons with abnormal thyroid functions, the frequency of chromosome aberrations (3.69%) was significantly higher (3.69%) than in exposed subjects without thyroid alterations (2.43%) and in controls (1.70% and 1.60% in control subjects with and without thyroid alterations, respectively). Significantly increased ratio of helper T lymphocytes and decreased ratio of cytotoxic T cells and transferrin-receptor (CD71) expressing B cells were observed in exposed subjects having abnormal thyroid functions as compared to controls. In addition, the ratio of B cells, CD71 expressing T cells and production of reactive oxygen-intermediates was significantly decreased in exposed subjects with thyroid alterations in comparison to exposed subjects without thyroid alterations. Conclusions: The results indicate increased geno- and immune-toxic effects among exposed subjects having thyroid alterations. Further data are needed to clearly establish the underlying pathophysiological mechanism of this finding. Orv. Hetil., 2015, 156(2), 60–66.

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